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MRPS18A mitochondrial ribosomal protein S18A [ Homo sapiens (human) ]

Gene ID: 55168, updated on 6-Sep-2017
Official Symbol
MRPS18Aprovided by HGNC
Official Full Name
mitochondrial ribosomal protein S18Aprovided by HGNC
Primary source
HGNC:HGNC:14515
See related
Ensembl:ENSG00000096080 MIM:611981; Vega:OTTHUMG00000014750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S18bmt; MRPS18-3; HumanS18b; MRP-S18-3
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. A pseudogene corresponding to this gene is found on chromosome 3p. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]
Orthologs
Location:
6p21.1
Exon count:
6
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (43671197..43687812, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43638934..43655549, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene MAD2L1 binding protein Neighboring gene radial spoke head 9 homolog Neighboring gene exosome component 8 pseudogene Neighboring gene vascular endothelial growth factor A

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Mitochondrial translation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation, organism-specific biosystemOf the roughly 1000 human mitochondrial proteins only 13 proteins, all of them hydrophobic inner membrane proteins that are components of the oxidative phosphorylation apparatus, are encoded in the m...
  • Mitochondrial translation elongation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation elongation, organism-specific biosystemTranslation elongation proceeds by cycles of aminoacyl-tRNAs binding, peptide bond formation, and displacement of deacylated tRNAs (reviewed in Christian and Spremulli 2012). In each cycle an aminoac...
  • Mitochondrial translation initiation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation initiation, organism-specific biosystemTranslation initiates with the mitochondrial mRNA binding the 28S subunit:MTIF3 (28S subunit:IF-3Mt, 28S subunit:IF3mt) complex together with MTIF2:GTP (IF-2Mt:GTP, IF2mt:GTP) (reviewed in Christian ...
  • Mitochondrial translation termination, organism-specific biosystem (from REACTOME)
    Mitochondrial translation termination, organism-specific biosystemTranslation is terminated when MTRF1L:GTP (MTRF1a:GTP) recognizes a UAA or UAG termination codon in the mRNA at the A site of the ribosome (Soleimanpour-Lichaei et al. 2007, reviewed in Richter et al...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • Ribosome, organism-specific biosystem (from KEGG)
    Ribosome, organism-specific biosystem
    Ribosome
  • Ribosome, conserved biosystem (from KEGG)
    Ribosome, conserved biosystem
    Ribosome
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ10548

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
39S ribosomal protein S18a, mitochondrial; 28S ribosomal protein S18a, mitochondrial
Names
28S ribosomal protein S18-3, mitochondrial
39S ribosomal protein S18-3, mitochondrial
MRP-S18-a
S18mt-a
mitochondrial large ribosomal subunit protein bS18a
mitochondrial large ribosomal subunit protein bS18m-A
mitochondrial large ribosomal subunit protein mL66
mitochondrial ribosomal protein S18-3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193343.1NP_001180272.1  39S ribosomal protein S18a, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_001180272.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region which results in a frameshift compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK300757, AL136131
    Consensus CDS
    CCDS55006.1
    UniProtKB/Swiss-Prot
    Q9NVS2
    Related
    ENSP00000361188.1, OTTHUMP00000016497, ENST00000372116.5, OTTHUMT00000040695
    Conserved Domains (1) summary
    pfam01084
    Location:78126
    Ribosomal_S18; Ribosomal protein S18
  2. NM_018135.3NP_060605.1  39S ribosomal protein S18a, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_060605.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AL136131, BC010364, CA420521
    Consensus CDS
    CCDS4906.1
    UniProtKB/Swiss-Prot
    Q9NVS2
    Related
    ENSP00000361206.3, OTTHUMP00000016499, ENST00000372133.7, OTTHUMT00000040697
    Conserved Domains (1) summary
    pfam01084
    Location:78128
    Ribosomal_S18; Ribosomal protein S18

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

    Range
    43671197..43687812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715134.2XP_006715197.1  28S ribosomal protein S18a, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006715197.1

    UniProtKB/Swiss-Prot
    Q9NVS2
    Related
    ENSP00000398679.1, OTTHUMP00000016498, ENST00000427312.1, OTTHUMT00000040696
    Conserved Domains (1) summary
    pfam01084
    Location:78126
    Ribosomal_S18; Ribosomal protein S18

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    43641931..43658546 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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