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SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor [ Homo sapiens (human) ]

Gene ID: 55164, updated on 8-Jul-2021

Summary

Official Symbol
SHQ1provided by HGNC
Official Full Name
SHQ1, H/ACA ribonucleoprotein assembly factorprovided by HGNC
Primary source
HGNC:HGNC:25543
See related
Ensembl:ENSG00000144736 MIM:613663
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Shq1p; GRIM-1
Summary
SHQ1 assists in the assembly of H/ACA-box ribonucleoproteins that function in the processing of ribosomal RNAs, modification of spliceosomal small nuclear RNAs, and stabilization of telomerase (see MIM 602322) (Grozdanov et al., 2009 [PubMed 19383767]).[supplied by OMIM, Dec 2010]
Expression
Ubiquitous expression in testis (RPKM 2.9), thyroid (RPKM 2.1) and 25 other tissues See more
Orthologs
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Genomic context

See SHQ1 in Genome Data Viewer
Location:
3p13
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (72725702..72848475, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (72798428..72897596, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377161 Neighboring gene uncharacterized LOC105377162 Neighboring gene RNA, 5S ribosomal pseudogene 136 Neighboring gene uncharacterized LOC107986097 Neighboring gene U2 snRNP-associated SURP motif-containing protein pseudogene Neighboring gene lysosomal protein transmembrane 4 beta pseudogene 2 Neighboring gene PSMD12 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10539, DKFZp686H07226

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
NOT located_in Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein SHQ1 homolog
Names
SHQ1 homolog
gene associated with retinoid and interferon-induced mortality 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018130.3NP_060600.2  protein SHQ1 homolog

    See identical proteins and their annotated locations for NP_060600.2

    Status: VALIDATED

    Source sequence(s)
    AK001401, BC032671
    Consensus CDS
    CCDS33788.1
    UniProtKB/Swiss-Prot
    Q6PI26
    Related
    ENSP00000315182.8, ENST00000325599.13
    Conserved Domains (2) summary
    cd06463
    Location:984
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    pfam04925
    Location:243412
    SHQ1; SHQ1 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    72725702..72848475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006724.1XP_016862213.1  protein SHQ1 homolog isoform X2

    Conserved Domains (2) summary
    cd06463
    Location:984
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    pfam04925
    Location:243395
    SHQ1; SHQ1 protein
  2. XM_011533898.2XP_011532200.1  protein SHQ1 homolog isoform X4

    Conserved Domains (2) summary
    cd06463
    Location:984
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    pfam04925
    Location:243394
    SHQ1; SHQ1 protein
  3. XM_011533896.2XP_011532198.1  protein SHQ1 homolog isoform X2

    Conserved Domains (2) summary
    cd06463
    Location:984
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    pfam04925
    Location:243395
    SHQ1; SHQ1 protein
  4. XM_011533897.2XP_011532199.1  protein SHQ1 homolog isoform X3

    Conserved Domains (2) summary
    cd06463
    Location:984
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    pfam04925
    Location:243394
    SHQ1; SHQ1 protein
  5. XM_011533895.2XP_011532197.1  protein SHQ1 homolog isoform X1

    Conserved Domains (2) summary
    cd06463
    Location:984
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    pfam04925
    Location:243394
    SHQ1; SHQ1 protein
  6. XM_011533899.1XP_011532201.1  protein SHQ1 homolog isoform X5

    Conserved Domains (2) summary
    cd06463
    Location:984
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    pfam04925
    Location:243313
    SHQ1; SHQ1 protein

RNA

  1. XR_001740192.2 RNA Sequence

  2. XR_001740193.1 RNA Sequence

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