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TMEM33 transmembrane protein 33 [ Homo sapiens (human) ]

Gene ID: 55161, updated on 7-Apr-2024

Summary

Official Symbol
TMEM33provided by HGNC
Official Full Name
transmembrane protein 33provided by HGNC
Primary source
HGNC:HGNC:25541
See related
Ensembl:ENSG00000109133 MIM:618515; AllianceGenome:HGNC:25541
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Pom33; SHINC3; SHINC-3; 1600019D15Rik
Summary
Involved in positive regulation of endoplasmic reticulum unfolded protein response; regulation of endoplasmic reticulum tubular network organization; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane; melanosome; and nuclear envelope. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 8.6), thyroid (RPKM 8.4) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM33 in Genome Data Viewer
Location:
4p13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (41935137..41960803)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (41908187..41934614)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (41937446..41962820)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900696 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:41910569-41911460 Neighboring gene uncharacterized LOC105374426 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:41914902-41916101 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21510 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:41983504-41984703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21511 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:41992428-41992647 Neighboring gene DDB1 and CUL4 associated factor 4 like 1 Neighboring gene solute carrier family 30 member 9 Neighboring gene ATPase Na+/K+ transporting subunit beta 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of transmembrane protein 33 (TMEM33) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ10525

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018126.3NP_060596.2  transmembrane protein 33

    See identical proteins and their annotated locations for NP_060596.2

    Status: VALIDATED

    Source sequence(s)
    AC106052, BC000948
    Consensus CDS
    CCDS3464.1
    UniProtKB/Swiss-Prot
    B3KSS8, P57088, Q9H953
    UniProtKB/TrEMBL
    A6QKW0
    Related
    ENSP00000422473.1, ENST00000504986.6
    Conserved Domains (1) summary
    pfam03661
    Location:9245
    UPF0121; Uncharacterized protein family (UPF0121)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    41935137..41960803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248116.5XP_005248173.1  transmembrane protein 33 isoform X1

    See identical proteins and their annotated locations for XP_005248173.1

    UniProtKB/Swiss-Prot
    B3KSS8, P57088, Q9H953
    UniProtKB/TrEMBL
    A6QKW0
    Related
    ENSP00000422810.1, ENST00000508448.5
    Conserved Domains (1) summary
    pfam03661
    Location:9245
    UPF0121; Uncharacterized protein family (UPF0121)
  2. XM_005248117.3XP_005248174.1  transmembrane protein 33 isoform X1

    See identical proteins and their annotated locations for XP_005248174.1

    UniProtKB/Swiss-Prot
    B3KSS8, P57088, Q9H953
    UniProtKB/TrEMBL
    A6QKW0
    Related
    ENSP00000427006.1, ENST00000513702.5
    Conserved Domains (1) summary
    pfam03661
    Location:9245
    UPF0121; Uncharacterized protein family (UPF0121)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    41908187..41934614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350372.1XP_054206347.1  transmembrane protein 33 isoform X1

    UniProtKB/Swiss-Prot
    B3KSS8, P57088, Q9H953
  2. XM_054350370.1XP_054206345.1  transmembrane protein 33 isoform X1

    UniProtKB/Swiss-Prot
    B3KSS8, P57088, Q9H953
  3. XM_054350371.1XP_054206346.1  transmembrane protein 33 isoform X1

    UniProtKB/Swiss-Prot
    B3KSS8, P57088, Q9H953