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TMEM33 transmembrane protein 33 [ Homo sapiens (human) ]

Gene ID: 55161, updated on 4-Nov-2018

Summary

Official Symbol
TMEM33provided by HGNC
Official Full Name
transmembrane protein 33provided by HGNC
Primary source
HGNC:HGNC:25541
See related
Ensembl:ENSG00000109133 Vega:OTTHUMG00000099381
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SHINC3; SHINC-3; 1600019D15Rik
Expression
Ubiquitous expression in brain (RPKM 8.6), thyroid (RPKM 8.4) and 25 other tissues See more
Orthologs

Genomic context

See TMEM33 in Genome Data Viewer
Location:
4p13
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (41935120..41960807)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (41937137..41962824)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374425 Neighboring gene high mobility group box 1 pseudogene 28 Neighboring gene uncharacterized LOC105374426 Neighboring gene long intergenic non-protein coding RNA 682 Neighboring gene DDB1 and CUL4 associated factor 4 like 1 Neighboring gene solute carrier family 30 member 9 Neighboring gene ATPase Na+/K+ transporting subunit beta 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of transmembrane protein 33 (TMEM33) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10525

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
melanosome IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018126.2NP_060596.2  transmembrane protein 33

    See identical proteins and their annotated locations for NP_060596.2

    Status: VALIDATED

    Source sequence(s)
    AC106052, AC108210, BC000948
    Consensus CDS
    CCDS3464.1
    UniProtKB/Swiss-Prot
    P57088
    UniProtKB/TrEMBL
    A0A024R9W7
    Related
    ENSP00000422473.1, OTTHUMP00000125225, ENST00000504986.5, OTTHUMT00000216834
    Conserved Domains (1) summary
    pfam03661
    Location:9245
    UPF0121; Uncharacterized protein family (UPF0121)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    41935120..41960807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248116.4XP_005248173.1  transmembrane protein 33 isoform X1

    See identical proteins and their annotated locations for XP_005248173.1

    UniProtKB/Swiss-Prot
    P57088
    UniProtKB/TrEMBL
    A0A024R9W7
    Related
    ENSP00000422810.1, OTTHUMP00000218396, ENST00000508448.5
    Conserved Domains (1) summary
    pfam03661
    Location:9245
    UPF0121; Uncharacterized protein family (UPF0121)
  2. XM_005248117.2XP_005248174.1  transmembrane protein 33 isoform X1

    See identical proteins and their annotated locations for XP_005248174.1

    UniProtKB/Swiss-Prot
    P57088
    UniProtKB/TrEMBL
    A0A024R9W7
    Related
    ENSP00000427006.1, OTTHUMP00000218397, ENST00000513702.5, OTTHUMT00000360963
    Conserved Domains (1) summary
    pfam03661
    Location:9245
    UPF0121; Uncharacterized protein family (UPF0121)
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