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MTPAP mitochondrial poly(A) polymerase [ Homo sapiens (human) ]

Gene ID: 55149, updated on 24-Nov-2020

Summary

Official Symbol
MTPAPprovided by HGNC
Official Full Name
mitochondrial poly(A) polymeraseprovided by HGNC
Primary source
HGNC:HGNC:25532
See related
Ensembl:ENSG00000107951 MIM:613669
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAPD1; SPAX4; TENT6
Summary
The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.[provided by RefSeq, Jan 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 4.8), testis (RPKM 4.4) and 25 other tissues See more
Orthologs

Genomic context

See MTPAP in Genome Data Viewer
Location:
10p11.23
Exon count:
9
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (30309801..30349278, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (30598730..30638267, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 598, pseudogene Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 39 Neighboring gene dynamin 1 pseudogene 17 Neighboring gene GOLGA2 pseudogene 6 Neighboring gene RNA, 7SL, cytoplasmic 241, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10486

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
UTP binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleotidyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
polynucleotide adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
polynucleotide adenylyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
histone mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA polyadenylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA polyadenylation IDA
Inferred from Direct Assay
more info
PubMed 
mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
poly(A) RNA polymerase, mitochondrial
Names
PAP-associated domain-containing protein 1
TUTase 1
polynucleotide adenylyltransferase
terminal uridylyltransferase 1
NP_060579.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028096.1 RefSeqGene

    Range
    5001..44538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018109.4NP_060579.3  poly(A) RNA polymerase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_060579.3

    Status: REVIEWED

    Source sequence(s)
    AL161651, AL353796
    Consensus CDS
    CCDS7165.1
    UniProtKB/Swiss-Prot
    Q9NVV4
    Related
    ENSP00000263063.3, ENST00000263063.8
    Conserved Domains (2) summary
    cd05402
    Location:206344
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    pfam03828
    Location:440483
    PAP_assoc; Cid1 family poly A polymerase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    30309801..30349278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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