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RBM23 RNA binding motif protein 23 [ Homo sapiens (human) ]

Gene ID: 55147, updated on 6-Jan-2019

Summary

Official Symbol
RBM23provided by HGNC
Official Full Name
RNA binding motif protein 23provided by HGNC
Primary source
HGNC:HGNC:20155
See related
Ensembl:ENSG00000100461
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP239; RNPC4; CAPERbeta
Summary
This gene encodes a member of the U2AF-like family of RNA binding proteins. This protein interacts with some steroid nuclear receptors, localizes to the promoter of a steroid- responsive gene, and increases transcription of steroid-responsive transcriptional reporters in a hormone-dependent manner. It is also implicated in the steroid receptor-dependent regulation of alternative splicing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 14.7), ovary (RPKM 12.8) and 25 other tissues See more
Orthologs

Genomic context

See RBM23 in Genome Data Viewer
Location:
14q11.2
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (22900645..22919187, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23369854..23388396, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene LDL receptor related protein 10 Neighboring gene RRAD and GEM like GTPase 2 Neighboring gene PRMT5 antisense RNA 1 Neighboring gene protein arginine methyltransferase 5 Neighboring gene uncharacterized LOC101926933 Neighboring gene transfer RNA-Arg (ACG) 1-3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4458, FLJ10482

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U1 snRNP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
3'-UTR-mediated mRNA destabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable RNA-binding protein 23
Names
RNA-binding region (RNP1, RRM) containing 4
RNA-binding region-containing protein 4
coactivator of activating protein-1 and estrogen recep- tors beta
splicing factor SF2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077351.2NP_001070819.1  probable RNA-binding protein 23 isoform 1

    See identical proteins and their annotated locations for NP_001070819.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL135998, BC106012, BX161440, CK003276
    Consensus CDS
    CCDS41921.1
    UniProtKB/Swiss-Prot
    Q86U06
    UniProtKB/TrEMBL
    A0A0S2Z5D9
    Related
    ENSP00000352956.3, ENST00000359890.7
    Conserved Domains (1) summary
    cl25887
    Location:99438
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  2. NM_001077352.1NP_001070820.1  probable RNA-binding protein 23 isoform 3

    See identical proteins and their annotated locations for NP_001070820.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1. The resulting protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AK001344, AL132780, BC106012, CK000110, CK003276
    Consensus CDS
    CCDS41919.1
    UniProtKB/Swiss-Prot
    Q86U06
    UniProtKB/TrEMBL
    A0A0S2Z5I1
    Related
    ENSP00000339220.5, ENST00000346528.9
    Conserved Domains (3) summary
    cd12284
    Location:231303
    RRM2_RBM23_RBM39; RNA recognition motif 2 in vertebrate RNA-binding protein RBM23, RBM39 and similar proteins
    cd12537
    Location:131215
    RRM1_RBM23; RNA recognition motif 1 in vertebrate probable RNA-binding protein 23 (RBM23)
    pfam15519
    Location:324404
    RBM39linker; linker between RRM2 and RRM3 domains in RBM39 protein
  3. NM_001308044.1NP_001294973.1  probable RNA-binding protein 23 isoform 4

    See identical proteins and their annotated locations for NP_001294973.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks two exons in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 4, which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA987387, AK303668, BX161440, CK000110, DC363343
    Consensus CDS
    CCDS76658.1
    UniProtKB/Swiss-Prot
    Q86U06
    UniProtKB/TrEMBL
    B7Z8M4, G3XAP0
    Related
    ENSP00000438504.2, ENST00000542016.6
    Conserved Domains (1) summary
    cl25887
    Location:1268
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  4. NM_001352762.1NP_001339691.1  probable RNA-binding protein 23 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL132780, AL135998
    Consensus CDS
    CCDS76658.1
    Conserved Domains (1) summary
    cl25887
    Location:1268
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  5. NM_001352763.1NP_001339692.1  probable RNA-binding protein 23 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL132780, AL135998
    Consensus CDS
    CCDS41921.1
    Conserved Domains (1) summary
    cl25887
    Location:99438
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  6. NM_001352764.1NP_001339693.1  probable RNA-binding protein 23 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL132780, AL135998
    Conserved Domains (1) summary
    cl25887
    Location:143482
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  7. NM_001352765.1NP_001339694.1  probable RNA-binding protein 23 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL132780, AL135998
    Consensus CDS
    CCDS41920.1
    Conserved Domains (1) summary
    cl25887
    Location:69422
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  8. NM_001352766.1NP_001339695.1  probable RNA-binding protein 23 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL132780, AL135998
    Consensus CDS
    CCDS41921.1
    Conserved Domains (1) summary
    cl25887
    Location:99438
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  9. NM_018107.4NP_060577.3  probable RNA-binding protein 23 isoform 2

    See identical proteins and their annotated locations for NP_060577.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AL135998, BC024208, BC106012, CK000110, CK003276
    Consensus CDS
    CCDS41920.1
    UniProtKB/Swiss-Prot
    Q86U06
    UniProtKB/TrEMBL
    A0A0S2Z5J3
    Related
    ENSP00000382806.2, ENST00000399922.6
    Conserved Domains (1) summary
    cl25887
    Location:69422
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    22900645..22919187 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536905.1XP_011535207.1  probable RNA-binding protein 23 isoform X27

    See identical proteins and their annotated locations for XP_011535207.1

    UniProtKB/TrEMBL
    G3XAP0
    Conserved Domains (1) summary
    cl25887
    Location:1268
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  2. XM_017021418.1XP_016876907.1  probable RNA-binding protein 23 isoform X26

  3. XM_017021415.1XP_016876904.1  probable RNA-binding protein 23 isoform X26

  4. XM_011536900.2XP_011535202.1  probable RNA-binding protein 23 isoform X17

    Conserved Domains (3) summary
    cd12284
    Location:247319
    RRM2_RBM23_RBM39; RNA recognition motif 2 in vertebrate RNA-binding protein RBM23, RBM39 and similar proteins
    cd12537
    Location:147231
    RRM1_RBM23; RNA recognition motif 1 in vertebrate probable RNA-binding protein 23 (RBM23)
    pfam15519
    Location:340420
    RBM39linker; linker between RRM2 and RRM3 domains in RBM39 protein
  5. XM_017021405.2XP_016876894.1  probable RNA-binding protein 23 isoform X9

  6. XM_017021401.2XP_016876890.1  probable RNA-binding protein 23 isoform X6

  7. XM_017021403.2XP_016876892.1  probable RNA-binding protein 23 isoform X8

  8. XM_024449642.1XP_024305410.1  probable RNA-binding protein 23 isoform X10

    Conserved Domains (1) summary
    cl25887
    Location:69449
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  9. XM_024449641.1XP_024305409.1  probable RNA-binding protein 23 isoform X3

    Conserved Domains (1) summary
    cl25887
    Location:139496
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  10. XM_024449640.1XP_024305408.1  probable RNA-binding protein 23 isoform X1

    Conserved Domains (1) summary
    cl25887
    Location:143514
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  11. XM_011536906.1XP_011535208.1  probable RNA-binding protein 23 isoform X27

    See identical proteins and their annotated locations for XP_011535208.1

    UniProtKB/TrEMBL
    G3XAP0
    Conserved Domains (1) summary
    cl25887
    Location:1268
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  12. XM_017021419.1XP_016876908.1  probable RNA-binding protein 23 isoform X26

  13. XM_011536903.1XP_011535205.1  probable RNA-binding protein 23 isoform X27

    See identical proteins and their annotated locations for XP_011535205.1

    UniProtKB/TrEMBL
    G3XAP0
    Conserved Domains (1) summary
    cl25887
    Location:1268
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  14. XM_017021416.1XP_016876905.1  probable RNA-binding protein 23 isoform X26

  15. XM_024449645.1XP_024305413.1  probable RNA-binding protein 23 isoform X24

    Conserved Domains (1) summary
    cl25887
    Location:16334
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  16. XM_011536902.1XP_011535204.1  probable RNA-binding protein 23 isoform X27

    See identical proteins and their annotated locations for XP_011535204.1

    UniProtKB/TrEMBL
    G3XAP0
    Conserved Domains (1) summary
    cl25887
    Location:1268
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  17. XM_017021414.1XP_016876903.1  probable RNA-binding protein 23 isoform X26

  18. XM_017021408.1XP_016876897.1  probable RNA-binding protein 23 isoform X13

  19. XM_017021399.2XP_016876888.1  probable RNA-binding protein 23 isoform X4

  20. XM_011536893.3XP_011535195.1  probable RNA-binding protein 23 isoform X7

    See identical proteins and their annotated locations for XP_011535195.1

    Conserved Domains (4) summary
    cd12284
    Location:293365
    RRM2_RBM23_RBM39; RNA recognition motif 2 in vertebrate RNA-binding protein RBM23, RBM39 and similar proteins
    cd12537
    Location:193277
    RRM1_RBM23; RNA recognition motif 1 in vertebrate probable RNA-binding protein 23 (RBM23)
    pfam13900
    Location:641
    GVQW; Putative domain of unknown function
    pfam15519
    Location:386466
    RBM39linker; linker between RRM2 and RRM3 domains in RBM39 protein
  21. XM_017021398.2XP_016876887.1  probable RNA-binding protein 23 isoform X2

  22. XM_011536904.1XP_011535206.1  probable RNA-binding protein 23 isoform X27

    See identical proteins and their annotated locations for XP_011535206.1

    UniProtKB/TrEMBL
    G3XAP0
    Conserved Domains (1) summary
    cl25887
    Location:1268
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  23. XM_017021417.1XP_016876906.1  probable RNA-binding protein 23 isoform X26

  24. XM_017021410.1XP_016876899.1  probable RNA-binding protein 23 isoform X21

    UniProtKB/TrEMBL
    A0A0S2Z5I1
    Conserved Domains (3) summary
    cd12284
    Location:231303
    RRM2_RBM23_RBM39; RNA recognition motif 2 in vertebrate RNA-binding protein RBM23, RBM39 and similar proteins
    cd12537
    Location:131215
    RRM1_RBM23; RNA recognition motif 1 in vertebrate probable RNA-binding protein 23 (RBM23)
    pfam15519
    Location:324404
    RBM39linker; linker between RRM2 and RRM3 domains in RBM39 protein
  25. XM_017021420.1XP_016876909.1  probable RNA-binding protein 23 isoform X27

    UniProtKB/TrEMBL
    G3XAP0
    Conserved Domains (1) summary
    cl25887
    Location:1268
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  26. XM_017021411.1XP_016876900.1  probable RNA-binding protein 23 isoform X22

  27. XM_011536897.2XP_011535199.1  probable RNA-binding protein 23 isoform X15

    Conserved Domains (3) summary
    cd12284
    Location:267339
    RRM2_RBM23_RBM39; RNA recognition motif 2 in vertebrate RNA-binding protein RBM23, RBM39 and similar proteins
    cd12537
    Location:167251
    RRM1_RBM23; RNA recognition motif 1 in vertebrate probable RNA-binding protein 23 (RBM23)
    pfam15519
    Location:360440
    RBM39linker; linker between RRM2 and RRM3 domains in RBM39 protein
  28. XM_017021400.2XP_016876889.1  probable RNA-binding protein 23 isoform X5

  29. XM_017021409.1XP_016876898.1  probable RNA-binding protein 23 isoform X19

  30. XM_017021406.1XP_016876895.1  probable RNA-binding protein 23 isoform X12

  31. XM_017021402.2XP_016876891.1  probable RNA-binding protein 23 isoform X6

  32. XM_024449643.1XP_024305411.1  probable RNA-binding protein 23 isoform X16

    Conserved Domains (1) summary
    cl25887
    Location:69422
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  33. XM_017021404.1XP_016876893.1  probable RNA-binding protein 23 isoform X8

  34. XM_011536895.3XP_011535197.1  probable RNA-binding protein 23 isoform X20

    See identical proteins and their annotated locations for XP_011535197.1

    Conserved Domains (4) summary
    cd12284
    Location:275347
    RRM2_RBM23_RBM39; RNA recognition motif 2 in vertebrate RNA-binding protein RBM23, RBM39 and similar proteins
    cd12537
    Location:175259
    RRM1_RBM23; RNA recognition motif 1 in vertebrate probable RNA-binding protein 23 (RBM23)
    pfam13900
    Location:641
    GVQW; Putative domain of unknown function
    pfam15519
    Location:368448
    RBM39linker; linker between RRM2 and RRM3 domains in RBM39 protein
  35. XM_011536894.2XP_011535196.1  probable RNA-binding protein 23 isoform X18

    Conserved Domains (4) summary
    cd12284
    Location:291363
    RRM2_RBM23_RBM39; RNA recognition motif 2 in vertebrate RNA-binding protein RBM23, RBM39 and similar proteins
    cd12537
    Location:191275
    RRM1_RBM23; RNA recognition motif 1 in vertebrate probable RNA-binding protein 23 (RBM23)
    pfam13900
    Location:641
    GVQW; Putative domain of unknown function
    pfam15519
    Location:384464
    RBM39linker; linker between RRM2 and RRM3 domains in RBM39 protein
  36. XM_024449646.1XP_024305414.1  probable RNA-binding protein 23 isoform X25

    Conserved Domains (1) summary
    cl25887
    Location:16302
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  37. XM_011536892.2XP_011535194.1  probable RNA-binding protein 23 isoform X14

    See identical proteins and their annotated locations for XP_011535194.1

    Conserved Domains (4) summary
    cd12284
    Location:293365
    RRM2_RBM23_RBM39; RNA recognition motif 2 in vertebrate RNA-binding protein RBM23, RBM39 and similar proteins
    cd12537
    Location:193277
    RRM1_RBM23; RNA recognition motif 1 in vertebrate probable RNA-binding protein 23 (RBM23)
    pfam13900
    Location:641
    GVQW; Putative domain of unknown function
    pfam15519
    Location:386466
    RBM39linker; linker between RRM2 and RRM3 domains in RBM39 protein
  38. XM_011536896.3XP_011535198.1  probable RNA-binding protein 23 isoform X11

    See identical proteins and their annotated locations for XP_011535198.1

    Conserved Domains (4) summary
    cd12284
    Location:275347
    RRM2_RBM23_RBM39; RNA recognition motif 2 in vertebrate RNA-binding protein RBM23, RBM39 and similar proteins
    cd12537
    Location:175259
    RRM1_RBM23; RNA recognition motif 1 in vertebrate probable RNA-binding protein 23 (RBM23)
    pfam13900
    Location:641
    GVQW; Putative domain of unknown function
    pfam15519
    Location:368448
    RBM39linker; linker between RRM2 and RRM3 domains in RBM39 protein
  39. XM_024449644.1XP_024305412.1  probable RNA-binding protein 23 isoform X23

    Conserved Domains (1) summary
    cl25887
    Location:143356
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
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