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CDCA8 cell division cycle associated 8 [ Homo sapiens (human) ]

Gene ID: 55143, updated on 1-Jun-2020

Summary

Official Symbol
CDCA8provided by HGNC
Official Full Name
cell division cycle associated 8provided by HGNC
Primary source
HGNC:HGNC:14629
See related
Ensembl:ENSG00000134690 MIM:609977
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BOR; DasraB; MESRGP; BOREALIN
Summary
This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]
Expression
Biased expression in testis (RPKM 14.3), bone marrow (RPKM 12.4) and 13 other tissues See more
Orthologs

Genomic context

See CDCA8 in Genome Data Viewer
Location:
1p34.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (37692516..37709719)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (38158073..38175391)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene R-spondin 1 Neighboring gene chromosome 1 open reading frame 109 Neighboring gene EPH receptor A10 Neighboring gene uncharacterized LOC105378650

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10468, FLJ12042

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
chromocenter IEA
Inferred from Electronic Annotation
more info
 
chromosome passenger complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome passenger complex IPI
Inferred from Physical Interaction
more info
PubMed 
chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
intercellular bridge IDA
Inferred from Direct Assay
more info
 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
borealin
Names
Dasra B
cell division cycle-associated protein 8
dasra-B
hDasra-B
pluripotent embryonic stem cell-related gene 3 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256875.2NP_001243804.1  borealin

    See identical proteins and their annotated locations for NP_001243804.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC001651, BC008079
    Consensus CDS
    CCDS424.1
    UniProtKB/Swiss-Prot
    Q53HL2
    Related
    ENSP00000362146.1, ENST00000373055.6
    Conserved Domains (2) summary
    pfam10444
    Location:2276
    Nbl1_Borealin_N; Nbl1 / Borealin N terminal
    pfam10512
    Location:163275
    Borealin; Cell division cycle-associated protein 8
  2. NM_018101.4NP_060571.1  borealin

    See identical proteins and their annotated locations for NP_060571.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AY508815, BC008079
    Consensus CDS
    CCDS424.1
    UniProtKB/Swiss-Prot
    Q53HL2
    Related
    ENSP00000316121.2, ENST00000327331.2
    Conserved Domains (2) summary
    pfam10444
    Location:2276
    Nbl1_Borealin_N; Nbl1 / Borealin N terminal
    pfam10512
    Location:163275
    Borealin; Cell division cycle-associated protein 8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    37692516..37709719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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