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HAUS2 HAUS augmin like complex subunit 2 [ Homo sapiens (human) ]

Gene ID: 55142, updated on 17-Jun-2019

Summary

Official Symbol
HAUS2provided by HGNC
Official Full Name
HAUS augmin like complex subunit 2provided by HGNC
Primary source
HGNC:HGNC:25530
See related
Ensembl:ENSG00000137814 MIM:613429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEP27; C15orf25; HsT17025
Summary
The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. [provided by RefSeq, Apr 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 7.1), brain (RPKM 3.8) and 25 other tissues See more
Orthologs

Genomic context

See HAUS2 in Genome Data Viewer
Location:
15q15.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (42548813..42569994)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42841011..42862192)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 106 Neighboring gene RNA, U6 small nuclear 188, pseudogene Neighboring gene synaptosome associated protein 23 Neighboring gene leucine rich repeat containing 57 Neighboring gene eukaryotic translation initiation factor 4E binding protein 2 pseudogene 2 Neighboring gene myosin light chain 12B pseudogene 1 Neighboring gene StAR related lipid transfer domain containing 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • AURKA Activation by TPX2, organism-specific biosystem (from REACTOME)
    AURKA Activation by TPX2, organism-specific biosystemTPX2 binds to aurora kinase A (AURKA) at centrosomes and promotes its activation by facilitating AURKA active conformation and autophosphorylation of the AURKA threonine residue T288 (Bayliss et al. ...
  • Anchoring of the basal body to the plasma membrane, organism-specific biosystem (from REACTOME)
    Anchoring of the basal body to the plasma membrane, organism-specific biosystemCilium biogenesis is initiated by the docking of basal bodies, a centriole-derived organelle, to the plasma membrane (reviewed in Reiter et al, 2012). The centriole consists of a multiprotein core su...
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Centrosome maturation, organism-specific biosystem (from REACTOME)
    Centrosome maturation, organism-specific biosystemThe centrosome is the primary microtubule organizing center (MTOC) in vertebrate cells and plays an important role in orchestrating the formation of the mitotic spindle. Centrosome maturation is an ...
  • Cilium Assembly, organism-specific biosystem (from REACTOME)
    Cilium Assembly, organism-specific biosystemCilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguishe...
  • G2/M Transition, organism-specific biosystem (from REACTOME)
    G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
  • Loss of Nlp from mitotic centrosomes, organism-specific biosystem (from REACTOME)
    Loss of Nlp from mitotic centrosomes, organism-specific biosystemDuring interphase, Nlp interacts with gamma-tubulin ring complexes (gamma-TuRC), and is thought to contribute to the organization of interphase microtubules (Casenghi et al.,2003). Plk1 is activated...
  • Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystem (from REACTOME)
    Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystemIn addition to recruiting proteins and complexes necessary for increased microtubule nucleation, centrosomal maturation involves the loss of proteins involved in interphase microtubule organization ...
  • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
    Mitotic G2-G2/M phases, organism-specific biosystem
    Mitotic G2-G2/M phases
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystem (from REACTOME)
    Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystemThe mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centro...
  • Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystem (from REACTOME)
    Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystemThe kinase activity of PLK1 is required for cell cycle progression as PLK1 phosphorylates and regulates a number of cellular proteins during mitosis. Centrosomic AURKA (Aurora A kinase), catalyticall...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10460

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
HAUS complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
spindle microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
HAUS augmin-like complex subunit 2
Names
centrosomal protein 27kDa
centrosomal protein of 27 kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130447.2NP_001123919.1  HAUS augmin-like complex subunit 2 isoform 2

    See identical proteins and their annotated locations for NP_001123919.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate, in-frame, segment in the CDS, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC018362, AI368236, DA923763, DB450370
    Consensus CDS
    CCDS45247.1
    UniProtKB/Swiss-Prot
    Q9NVX0
    Related
    ENSP00000456578.1, ENST00000568876.5
    Conserved Domains (1) summary
    pfam15003
    Location:8159
    HAUS2; HAUS augmin-like complex subunit 2
  2. NM_001323629.1NP_001310558.1  HAUS augmin-like complex subunit 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC018362
    Consensus CDS
    CCDS81867.1
    UniProtKB/TrEMBL
    H3BP16
    Related
    ENSP00000491926.1, ENST00000639412.1
  3. NM_001323630.2NP_001310559.1  HAUS augmin-like complex subunit 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC018362
  4. NM_001323631.2NP_001310560.1  HAUS augmin-like complex subunit 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC018362
    UniProtKB/Swiss-Prot
    Q9NVX0
    UniProtKB/TrEMBL
    A0A024R9M5
    Conserved Domains (1) summary
    pfam15003
    Location:196
    HAUS2; HAUS augmin-like complex subunit 2
  5. NM_001323632.2NP_001310561.1  HAUS augmin-like complex subunit 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC018362
    UniProtKB/Swiss-Prot
    Q9NVX0
    UniProtKB/TrEMBL
    A0A024R9M5
    Conserved Domains (1) summary
    pfam15003
    Location:196
    HAUS2; HAUS augmin-like complex subunit 2
  6. NM_018097.3NP_060567.1  HAUS augmin-like complex subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_060567.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC018362, AI368236, BC010903
    Consensus CDS
    CCDS10090.1
    UniProtKB/Swiss-Prot
    Q9NVX0
    UniProtKB/TrEMBL
    A0A024R9P0
    Related
    ENSP00000260372.3, ENST00000260372.8
    Conserved Domains (1) summary
    pfam15003
    Location:8190
    HAUS2; HAUS augmin-like complex subunit 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    42548813..42569994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022396.1XP_016877885.1  HAUS augmin-like complex subunit 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9NVX0
    UniProtKB/TrEMBL
    A0A024R9M5
    Conserved Domains (1) summary
    pfam15003
    Location:196
    HAUS2; HAUS augmin-like complex subunit 2
  2. XM_017022397.1XP_016877886.1  HAUS augmin-like complex subunit 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9NVX0
    UniProtKB/TrEMBL
    A0A024R9M5
    Conserved Domains (1) summary
    pfam15003
    Location:196
    HAUS2; HAUS augmin-like complex subunit 2
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