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HAUS2 HAUS augmin like complex subunit 2 [ Homo sapiens (human) ]

Gene ID: 55142, updated on 7-Jun-2020

Summary

Official Symbol
HAUS2provided by HGNC
Official Full Name
HAUS augmin like complex subunit 2provided by HGNC
Primary source
HGNC:HGNC:25530
See related
Ensembl:ENSG00000137814 MIM:613429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEP27; C15orf25; HsT17025
Summary
The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. [provided by RefSeq, Apr 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 7.1), brain (RPKM 3.8) and 25 other tissues See more
Orthologs

Genomic context

See HAUS2 in Genome Data Viewer
Location:
15q15.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (42548813..42569994)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42841011..42862192)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 106 Neighboring gene RNA, U6 small nuclear 188, pseudogene Neighboring gene synaptosome associated protein 23 Neighboring gene leucine rich repeat containing 57 Neighboring gene eukaryotic translation initiation factor 4E binding protein 2 pseudogene 2 Neighboring gene myosin light chain 12B pseudogene 1 Neighboring gene StAR related lipid transfer domain containing 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10460

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
HAUS complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
spindle microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
HAUS augmin-like complex subunit 2
Names
centrosomal protein 27kDa
centrosomal protein of 27 kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130447.2NP_001123919.1  HAUS augmin-like complex subunit 2 isoform 2

    See identical proteins and their annotated locations for NP_001123919.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate, in-frame, segment in the CDS, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC018362, AI368236, DA923763, DB450370
    Consensus CDS
    CCDS45247.1
    UniProtKB/Swiss-Prot
    Q9NVX0
    Related
    ENSP00000456578.1, ENST00000568876.5
    Conserved Domains (1) summary
    pfam15003
    Location:8159
    HAUS2; HAUS augmin-like complex subunit 2
  2. NM_001323629.1NP_001310558.1  HAUS augmin-like complex subunit 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC018362
    Consensus CDS
    CCDS81867.1
    UniProtKB/TrEMBL
    H3BP16
    Related
    ENSP00000455104.1, ENST00000564279.5
  3. NM_001323630.2NP_001310559.1  HAUS augmin-like complex subunit 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC018362
  4. NM_001323631.2NP_001310560.1  HAUS augmin-like complex subunit 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC018362
    UniProtKB/Swiss-Prot
    Q9NVX0
    UniProtKB/TrEMBL
    A0A024R9M5
    Conserved Domains (1) summary
    pfam15003
    Location:196
    HAUS2; HAUS augmin-like complex subunit 2
  5. NM_001323632.2NP_001310561.1  HAUS augmin-like complex subunit 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC018362
    UniProtKB/Swiss-Prot
    Q9NVX0
    UniProtKB/TrEMBL
    A0A024R9M5
    Conserved Domains (1) summary
    pfam15003
    Location:196
    HAUS2; HAUS augmin-like complex subunit 2
  6. NM_018097.3NP_060567.1  HAUS augmin-like complex subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_060567.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC018362, AI368236, BC010903
    Consensus CDS
    CCDS10090.1
    UniProtKB/Swiss-Prot
    Q9NVX0
    UniProtKB/TrEMBL
    A0A024R9P0
    Related
    ENSP00000260372.3, ENST00000260372.8
    Conserved Domains (1) summary
    pfam15003
    Location:8190
    HAUS2; HAUS augmin-like complex subunit 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    42548813..42569994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022396.1XP_016877885.1  HAUS augmin-like complex subunit 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9NVX0
    UniProtKB/TrEMBL
    A0A024R9M5
    Conserved Domains (1) summary
    pfam15003
    Location:196
    HAUS2; HAUS augmin-like complex subunit 2
  2. XM_017022397.1XP_016877886.1  HAUS augmin-like complex subunit 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9NVX0
    UniProtKB/TrEMBL
    A0A024R9M5
    Conserved Domains (1) summary
    pfam15003
    Location:196
    HAUS2; HAUS augmin-like complex subunit 2
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