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PPP1R10 protein phosphatase 1 regulatory subunit 10 [ Homo sapiens (human) ]

Gene ID: 5514, updated on 7-Jun-2020

Summary

Official Symbol
PPP1R10provided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 10provided by HGNC
Primary source
HGNC:HGNC:9284
See related
Ensembl:ENSG00000204569 MIM:603771
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p99; FB19; R111; CAT53; PNUTS; PP1R10
Summary
This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in thyroid (RPKM 17.1), adrenal (RPKM 16.4) and 25 other tissues See more
Orthologs

Genomic context

See PPP1R10 in Genome Data Viewer
Location:
6p21.33
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (30600400..30618607, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30568177..30585084, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene proline rich 3 Neighboring gene ABCF1 divergent transcript Neighboring gene ATP binding cassette subfamily F member 1 Neighboring gene microRNA 877 Neighboring gene mitochondrial ribosomal protein S18B Neighboring gene Sharpr-MPRA regulatory region 13793 Neighboring gene alpha tubulin acetyltransferase 1 Neighboring gene prothymosin alpha pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV transcription is restricted by the dissociation of a functional P-TEFb complex (CCNT1-CDK9) caused by PPP1R10 (PNUTS) PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Depletion of protein phosphatase 1, regulatory subunit 10 (PPP1R10) by siRNA enhances HIV-1 Tat activation of HIV-1 LTR, which is not the results of increased Tat expression and release of CDK9/CCNT1 from 7SK snRNP, and activation of NF-kappaB PubMed
capsid gag CA expression increases whilst endogeneous PPP1R10 (PNUTS) expression decreases in HIV-1 (NL4-3) infected MOLT-3 cells over time PubMed
gag MIR34A (miR-34A)-mediated increase in CA expression is inversely proportional to PPP1R10 (PNUTS) expression in HEK 293T cells co-transfected with pNL4-3, MIR34A and Myc-PNUTS PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PTW/PP1 phosphatase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
chromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
colocalizes_with nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 1 regulatory subunit 10
Names
HLA-C associated transcript 53
MHC class I region proline-rich protein CAT53
PP1-binding protein of 114 kDa
phosphatase 1 nuclear targeting subunit
protein phosphatase 1, regulatory (inhibitor) subunit 10
testis tissue sperm-binding protein Li 67n

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376195.1NP_001363124.1  serine/threonine-protein phosphatase 1 regulatory subunit 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1 and 3 both encode the same protein.
    Source sequence(s)
    AL662800
  2. NM_002714.4NP_002705.2  serine/threonine-protein phosphatase 1 regulatory subunit 10

    See identical proteins and their annotated locations for NP_002705.2

    Status: REVIEWED

    Source sequence(s)
    AJ544537, BC150310
    Consensus CDS
    CCDS4681.1
    UniProtKB/Swiss-Prot
    Q96QC0
    UniProtKB/TrEMBL
    Q2L6I0
    Related
    ENSP00000365694.2, ENST00000376511.7
    Conserved Domains (3) summary
    pfam00642
    Location:909932
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl00146
    Location:102146
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
    cl02637
    Location:102215
    TFIIS_M; Transcription factor S-II (TFIIS), central domain

RNA

  1. NR_072994.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL662800
  2. NR_164780.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL662800
  3. NR_164781.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL662800

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    30600400..30618607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514722.1XP_011513024.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    See identical proteins and their annotated locations for XP_011513024.1

    UniProtKB/Swiss-Prot
    Q96QC0
    UniProtKB/TrEMBL
    Q2L6I0
    Conserved Domains (3) summary
    pfam00642
    Location:909932
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl00146
    Location:102146
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
    cl02637
    Location:102215
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  2. XM_006715130.2XP_006715193.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    See identical proteins and their annotated locations for XP_006715193.1

    UniProtKB/Swiss-Prot
    Q96QC0
    UniProtKB/TrEMBL
    Q2L6I0
    Conserved Domains (3) summary
    pfam00642
    Location:909932
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl00146
    Location:102146
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
    cl02637
    Location:102215
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  3. XM_017010995.1XP_016866484.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    UniProtKB/Swiss-Prot
    Q96QC0
    UniProtKB/TrEMBL
    Q2L6I0
    Conserved Domains (3) summary
    pfam00642
    Location:909932
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl00146
    Location:102146
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
    cl02637
    Location:102215
    TFIIS_M; Transcription factor S-II (TFIIS), central domain

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    2080137..2096967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    1856243..1873073 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p13 ALT_REF_LOCI_4

    Range
    1910642..1927472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    1944460..1961291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    1855502..1872331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    1901171..1918001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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