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ANKZF1 ankyrin repeat and zinc finger domain containing 1 [ Homo sapiens (human) ]

Gene ID: 55139, updated on 9-Sep-2018

Summary

Official Symbol
ANKZF1provided by HGNC
Official Full Name
ankyrin repeat and zinc finger domain containing 1provided by HGNC
Primary source
HGNC:HGNC:25527
See related
Ensembl:ENSG00000163516 MIM:617541; Vega:OTTHUMG00000154533
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF744
Expression
Ubiquitous expression in lymph node (RPKM 19.0), spleen (RPKM 18.7) and 25 other tissues See more
Orthologs

Genomic context

See ANKZF1 in Genome Data Viewer
Location:
2q35
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (219229757..219236669)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220094479..220101391)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily B member 6 (Langereis blood group) Neighboring gene autophagy related 9A Neighboring gene galactosidase beta 1 like Neighboring gene serine/threonine kinase 16 Neighboring gene tubulin alpha 4a Neighboring gene tubulin alpha 4b

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10415, FLJ13144

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to thiol-dependent ubiquitin-specific protease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondria-associated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear protein quality control by the ubiquitin-proteasome system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Cdc48p-Npl4p-Vms1p AAA ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 

General protein information

Preferred Names
ankyrin repeat and zinc finger domain-containing protein 1
Names
zinc finger protein 744

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042410.1NP_001035869.1  ankyrin repeat and zinc finger domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001035869.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK023206, BC028334, DA899467
    Consensus CDS
    CCDS42821.1
    UniProtKB/Swiss-Prot
    Q9H8Y5
    UniProtKB/TrEMBL
    A0A024R464
    Related
    ENSP00000386337.3, OTTHUMP00000205943, ENST00000410034.7, OTTHUMT00000335797
    Conserved Domains (5) summary
    smart00451
    Location:69103
    ZnF_U1; U1-like zinc finger
    cd00204
    Location:495578
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00020
    Location:7496
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13637
    Location:495555
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:495532
    ANK; ANK repeat [structural motif]
  2. NM_001282792.1NP_001269721.1  ankyrin repeat and zinc finger domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three consecutive exons in the 5' region, and initiates translation at a downstream AUG codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA482007, AK225275, BC028334, DA226194
    Consensus CDS
    CCDS63129.1
    UniProtKB/TrEMBL
    B8ZZS4
    Related
    ENSP00000386815.1, OTTHUMP00000205942, ENST00000409849.5, OTTHUMT00000335792
    Conserved Domains (3) summary
    cd00204
    Location:285368
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13637
    Location:285345
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:285322
    ANK; ANK repeat [structural motif]
  3. NM_018089.2NP_060559.2  ankyrin repeat and zinc finger domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_060559.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1)represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC008948, BC028334, DA226194
    Consensus CDS
    CCDS42821.1
    UniProtKB/Swiss-Prot
    Q9H8Y5
    UniProtKB/TrEMBL
    A0A024R464
    Related
    ENSP00000321617.5, OTTHUMP00000205941, ENST00000323348.9, OTTHUMT00000335790
    Conserved Domains (5) summary
    smart00451
    Location:69103
    ZnF_U1; U1-like zinc finger
    cd00204
    Location:495578
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00020
    Location:7496
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13637
    Location:495555
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:495532
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    219229757..219236669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511392.3XP_011509694.1  ankyrin repeat and zinc finger domain-containing protein 1 isoform X1

    Conserved Domains (5) summary
    smart00451
    Location:69103
    ZnF_U1; U1-like zinc finger
    cd00204
    Location:494577
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00020
    Location:7496
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13637
    Location:494554
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:494531
    ANK; ANK repeat [structural motif]
  2. XM_017004421.2XP_016859910.1  ankyrin repeat and zinc finger domain-containing protein 1 isoform X4

  3. XM_005246663.3XP_005246720.1  ankyrin repeat and zinc finger domain-containing protein 1 isoform X2

    Conserved Domains (5) summary
    smart00451
    Location:438
    ZnF_U1; U1-like zinc finger
    cd00204
    Location:430513
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00020
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13637
    Location:430490
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:430467
    ANK; ANK repeat [structural motif]
  4. XM_017004420.2XP_016859909.1  ankyrin repeat and zinc finger domain-containing protein 1 isoform X3

RNA

  1. XR_001738809.2 RNA Sequence

    Related
    ENST00000463792.5
  2. XR_001738808.2 RNA Sequence

    Related
    ENST00000477479.5
  3. XR_001738810.2 RNA Sequence

  4. XR_427097.2 RNA Sequence

  5. XR_922953.2 RNA Sequence

  6. XR_427096.2 RNA Sequence

  7. XR_922952.2 RNA Sequence

  8. XR_001738807.2 RNA Sequence

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