Format

Send to:

Choose Destination

SRBD1 S1 RNA binding domain 1 [ Homo sapiens (human) ]

Gene ID: 55133, updated on 4-Jul-2021

Summary

Official Symbol
SRBD1provided by HGNC
Official Full Name
S1 RNA binding domain 1provided by HGNC
Primary source
HGNC:HGNC:25521
See related
Ensembl:ENSG00000068784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 5.6), testis (RPKM 5.3) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SRBD1 in Genome Data Viewer
Location:
2p21
Exon count:
23
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (45388680..45611294, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (45615819..45838406, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374576 Neighboring gene long intergenic non-protein coding RNA 1121 Neighboring gene uncharacterized LOC105374577 Neighboring gene RNA, 7SL, cytoplasmic 414, pseudogene Neighboring gene uncharacterized LOC102724965 Neighboring gene Sharpr-MPRA regulatory region 4153 Neighboring gene PRKCE antisense RNA 1 Neighboring gene protein kinase C epsilon

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of normal tension glaucoma: common variants in SRBD1 and ELOVL5 contribute to disease susceptibility.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, S1 RNA binding domain 1 (SRBD1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10379

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
S1 RNA-binding domain-containing protein 1
Names
H_NH0576F01.1
WUGSC:H_NH0576F01.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018079.5NP_060549.4  S1 RNA-binding domain-containing protein 1

    See identical proteins and their annotated locations for NP_060549.4

    Status: VALIDATED

    Source sequence(s)
    AK056536, BC032538, DA235970
    Consensus CDS
    CCDS1823.1
    UniProtKB/Swiss-Prot
    Q8N5C6
    Related
    ENSP00000263736.4, ENST00000263736.5
    Conserved Domains (5) summary
    COG2183
    Location:208991
    Tex; Transcriptional accessory protein Tex/SPT6 [Transcription]
    cd05685
    Location:919990
    S1_Tex; S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression. ...
    pfam09371
    Location:219414
    Tex_N; Tex-like protein N-terminal domain
    pfam12836
    Location:705767
    HHH_3; Helix-hairpin-helix motif
    pfam16921
    Location:538663
    Tex_YqgF; Tex protein YqgF-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    45388680..45611294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532946.2XP_011531248.1  S1 RNA-binding domain-containing protein 1 isoform X1

    Conserved Domains (5) summary
    COG2183
    Location:208975
    Tex; Transcriptional accessory protein Tex/SPT6 [Transcription]
    cd05685
    Location:903974
    S1_Tex; S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression. ...
    pfam09371
    Location:219414
    Tex_N; Tex-like protein N-terminal domain
    pfam12836
    Location:689751
    HHH_3; Helix-hairpin-helix motif
    cl21482
    Location:538647
    RuvC_resolvase; Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes ...
  2. XM_017004418.1XP_016859907.1  S1 RNA-binding domain-containing protein 1 isoform X2

RNA

  1. XR_939693.3 RNA Sequence

  2. XR_001738806.2 RNA Sequence

  3. XR_001738805.2 RNA Sequence

  4. XR_002959310.1 RNA Sequence

  5. XR_001738804.2 RNA Sequence

Support Center