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CEP192 centrosomal protein 192 [ Homo sapiens (human) ]

Gene ID: 55125, updated on 7-Jul-2019

Summary

Official Symbol
CEP192provided by HGNC
Official Full Name
centrosomal protein 192provided by HGNC
Primary source
HGNC:HGNC:25515
See related
Ensembl:ENSG00000101639 MIM:616426
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPP1R62
Expression
Ubiquitous expression in testis (RPKM 8.2), gall bladder (RPKM 6.1) and 25 other tissues See more
Orthologs

Genomic context

See CEP192 in Genome Data Viewer
Location:
18p11.21
Exon count:
46
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (12991301..13125053)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (12991352..13125052)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 1 Neighboring gene SEH1 like nucleoporin Neighboring gene Sharpr-MPRA regulatory region 6122 Neighboring gene MRT4 homolog, ribosome maturation factor pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • AURKA Activation by TPX2, organism-specific biosystem (from REACTOME)
    AURKA Activation by TPX2, organism-specific biosystemTPX2 binds to aurora kinase A (AURKA) at centrosomes and promotes its activation by facilitating AURKA active conformation and autophosphorylation of the AURKA threonine residue T288 (Bayliss et al. ...
  • Anchoring of the basal body to the plasma membrane, organism-specific biosystem (from REACTOME)
    Anchoring of the basal body to the plasma membrane, organism-specific biosystemCilium biogenesis is initiated by the docking of basal bodies, a centriole-derived organelle, to the plasma membrane (reviewed in Reiter et al, 2012). The centriole consists of a multiprotein core su...
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Centrosome maturation, organism-specific biosystem (from REACTOME)
    Centrosome maturation, organism-specific biosystemThe centrosome is the primary microtubule organizing center (MTOC) in vertebrate cells and plays an important role in orchestrating the formation of the mitotic spindle. Centrosome maturation is an ...
  • Cilium Assembly, organism-specific biosystem (from REACTOME)
    Cilium Assembly, organism-specific biosystemCilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguishe...
  • G2/M Transition, organism-specific biosystem (from REACTOME)
    G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
  • Gastric Cancer Network 1, organism-specific biosystem (from WikiPathways)
    Gastric Cancer Network 1, organism-specific biosystemNetwork generated by mapping candidate oncogenes and tumor suppressor genes identified by integrated analysis of expression array and aCGH data. Networks generated by Ingenuity Pathway Analysis.
  • Loss of Nlp from mitotic centrosomes, organism-specific biosystem (from REACTOME)
    Loss of Nlp from mitotic centrosomes, organism-specific biosystemDuring interphase, Nlp interacts with gamma-tubulin ring complexes (gamma-TuRC), and is thought to contribute to the organization of interphase microtubules (Casenghi et al.,2003). Plk1 is activated...
  • Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystem (from REACTOME)
    Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystemIn addition to recruiting proteins and complexes necessary for increased microtubule nucleation, centrosomal maturation involves the loss of proteins involved in interphase microtubule organization ...
  • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
    Mitotic G2-G2/M phases, organism-specific biosystem
    Mitotic G2-G2/M phases
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystem (from REACTOME)
    Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystemThe mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centro...
  • Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystem (from REACTOME)
    Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystemThe kinase activity of PLK1 is required for cell cycle progression as PLK1 phosphorylates and regulates a number of cellular proteins during mitosis. Centrosomic AURKA (Aurora A kinase), catalyticall...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
centrosome duplication IEA
Inferred from Electronic Annotation
more info
 
centrosome-templated microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
PubMed 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
response to bacterium IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centriole IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
pericentriolar material IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
centrosomal protein of 192 kDa
Names
192 kDa centrosomal protein
centrosomal protein 192kDa
cep192/SPD-2
protein phosphatase 1, regulatory subunit 62

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032142.4NP_115518.3  centrosomal protein of 192 kDa

    Status: VALIDATED

    Source sequence(s)
    AB046789, AK096548, AL833494, BC144481, BX648232, DB079620
    Consensus CDS
    CCDS32792.2
    UniProtKB/Swiss-Prot
    Q8TEP8
    UniProtKB/TrEMBL
    Q9HCK3
    Related
    ENSP00000427550.1, ENST00000506447.5
    Conserved Domains (1) summary
    pfam08626
    Location:16771767
    TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    12991301..13125053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525675.3XP_011523977.2  centrosomal protein of 192 kDa isoform X6

    Conserved Domains (1) summary
    pfam08626
    Location:15871677
    TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
  2. XM_024451196.1XP_024306964.1  centrosomal protein of 192 kDa isoform X10

    Conserved Domains (1) summary
    pfam08626
    Location:10811171
    TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
  3. XM_024451197.1XP_024306965.1  centrosomal protein of 192 kDa isoform X12

    Conserved Domains (1) summary
    pfam08626
    Location:9951085
    TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
  4. XM_006722326.3XP_006722389.1  centrosomal protein of 192 kDa isoform X2

    Conserved Domains (1) summary
    cl13764
    Location:16601724
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  5. XM_005258107.3XP_005258164.1  centrosomal protein of 192 kDa isoform X1

    Conserved Domains (1) summary
    cl13764
    Location:16601724
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  6. XM_011525673.2XP_011523975.1  centrosomal protein of 192 kDa isoform X3

    Conserved Domains (1) summary
    cl13764
    Location:16601727
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  7. XM_005258109.3XP_005258166.1  centrosomal protein of 192 kDa isoform X4

    Conserved Domains (1) summary
    cl13764
    Location:15901654
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  8. XM_006722327.3XP_006722390.1  centrosomal protein of 192 kDa isoform X5

    Related
    ENSP00000317156.9, ENST00000325971.12
    Conserved Domains (1) summary
    cl13764
    Location:15901654
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  9. XM_006722330.3XP_006722393.1  centrosomal protein of 192 kDa isoform X8

    Conserved Domains (1) summary
    cl13764
    Location:13211385
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  10. XM_017025804.1XP_016881293.1  centrosomal protein of 192 kDa isoform X9

  11. XM_017025803.2XP_016881292.1  centrosomal protein of 192 kDa isoform X7

    Related
    ENSP00000423147.1, ENST00000510237.5
  12. XM_017025806.1XP_016881295.1  centrosomal protein of 192 kDa isoform X11

    Related
    ENSP00000467038.1, ENST00000511820.6
  13. XM_017025807.1XP_016881296.1  centrosomal protein of 192 kDa isoform X13

RNA

  1. XR_001753206.1 RNA Sequence

  2. XR_002958178.1 RNA Sequence

  3. XR_001753207.1 RNA Sequence

  4. XR_243809.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018069.2: Suppressed sequence

    Description
    NM_018069.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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