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CEP192 centrosomal protein 192 [ Homo sapiens (human) ]

Gene ID: 55125, updated on 24-Nov-2020

Summary

Official Symbol
CEP192provided by HGNC
Official Full Name
centrosomal protein 192provided by HGNC
Primary source
HGNC:HGNC:25515
See related
Ensembl:ENSG00000101639 MIM:616426
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPP1R62
Expression
Ubiquitous expression in testis (RPKM 8.2), gall bladder (RPKM 6.1) and 25 other tissues See more
Orthologs

Genomic context

See CEP192 in Genome Data Viewer
Location:
18p11.21
Exon count:
46
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (12991301..13125053)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (12991352..13125052)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 1 Neighboring gene SEH1 like nucleoporin Neighboring gene Sharpr-MPRA regulatory region 6122 Neighboring gene MRT4 homolog, ribosome maturation factor pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
centrosome duplication IEA
Inferred from Electronic Annotation
more info
 
centrosome-templated microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
PubMed 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
response to bacterium IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centriole IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
pericentriolar material IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
centrosomal protein of 192 kDa
Names
192 kDa centrosomal protein
centrosomal protein 192kDa
cep192/SPD-2
protein phosphatase 1, regulatory subunit 62

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032142.4NP_115518.3  centrosomal protein of 192 kDa

    Status: VALIDATED

    Source sequence(s)
    AB046789, AK096548, AL833494, BC144481, BX648232, DB079620
    Consensus CDS
    CCDS32792.2
    UniProtKB/Swiss-Prot
    Q8TEP8
    UniProtKB/TrEMBL
    Q9HCK3
    Related
    ENSP00000427550.1, ENST00000506447.5
    Conserved Domains (1) summary
    pfam08626
    Location:16771767
    TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    12991301..13125053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525675.3XP_011523977.2  centrosomal protein of 192 kDa isoform X6

    Conserved Domains (1) summary
    pfam08626
    Location:15871677
    TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
  2. XM_024451196.1XP_024306964.1  centrosomal protein of 192 kDa isoform X10

    Conserved Domains (1) summary
    pfam08626
    Location:10811171
    TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
  3. XM_024451197.1XP_024306965.1  centrosomal protein of 192 kDa isoform X12

    Conserved Domains (1) summary
    pfam08626
    Location:9951085
    TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
  4. XM_006722326.3XP_006722389.1  centrosomal protein of 192 kDa isoform X2

    Conserved Domains (1) summary
    cl13764
    Location:16601724
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  5. XM_005258107.3XP_005258164.1  centrosomal protein of 192 kDa isoform X1

    Conserved Domains (1) summary
    cl13764
    Location:16601724
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  6. XM_011525673.2XP_011523975.1  centrosomal protein of 192 kDa isoform X3

    Conserved Domains (1) summary
    cl13764
    Location:16601727
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  7. XM_005258109.3XP_005258166.1  centrosomal protein of 192 kDa isoform X4

    Conserved Domains (1) summary
    cl13764
    Location:15901654
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  8. XM_006722327.3XP_006722390.1  centrosomal protein of 192 kDa isoform X5

    Related
    ENSP00000317156.9, ENST00000325971.12
    Conserved Domains (1) summary
    cl13764
    Location:15901654
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  9. XM_006722330.3XP_006722393.1  centrosomal protein of 192 kDa isoform X8

    Conserved Domains (1) summary
    cl13764
    Location:13211385
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  10. XM_017025804.1XP_016881293.1  centrosomal protein of 192 kDa isoform X9

  11. XM_017025803.2XP_016881292.1  centrosomal protein of 192 kDa isoform X7

    Related
    ENSP00000423147.1, ENST00000510237.5
  12. XM_017025806.1XP_016881295.1  centrosomal protein of 192 kDa isoform X11

    Related
    ENSP00000467038.1, ENST00000511820.6
  13. XM_017025807.1XP_016881296.1  centrosomal protein of 192 kDa isoform X13

RNA

  1. XR_001753206.1 RNA Sequence

  2. XR_002958178.1 RNA Sequence

  3. XR_001753207.1 RNA Sequence

  4. XR_243809.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018069.2: Suppressed sequence

    Description
    NM_018069.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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