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CEP192 centrosomal protein 192 [ Homo sapiens (human) ]

Gene ID: 55125, updated on 26-Jan-2024

Summary

Official Symbol
CEP192provided by HGNC
Official Full Name
centrosomal protein 192provided by HGNC
Primary source
HGNC:HGNC:25515
See related
Ensembl:ENSG00000101639 MIM:616426; AllianceGenome:HGNC:25515
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPP1R62
Summary
Enables phosphatase binding activity. Involved in centrosome-templated microtubule nucleation; mitotic spindle assembly; and protein localization to centrosome. Located in centriole; centrosome; and cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 8.2), gall bladder (RPKM 6.1) and 25 other tissues See more
Orthologs
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Genomic context

See CEP192 in Genome Data Viewer
Location:
18p11.21
Exon count:
47
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (12991362..13125036)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (13154097..13287771)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (12991361..13125035)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 933 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9323 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9324 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:12948589-12949190 Neighboring gene SEH1 like nucleoporin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:12989680-12990292 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9326 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9327 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9328 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:13061945-13062156 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:13068543-13069742 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13135678-13136257 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13136258-13136836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13113 Neighboring gene Sharpr-MPRA regulatory region 6122 Neighboring gene WD repeat domain 89 pseudogene Neighboring gene MRT4 homolog, ribosome maturation factor pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in centriole replication NAS
Non-traceable Author Statement
more info
PubMed 
involved_in centrosome-templated microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in centrosome-templated microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in pericentriolar material IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in procentriole IDA
Inferred from Direct Assay
more info
PubMed 
part_of procentriole replication complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
centrosomal protein of 192 kDa
Names
192 kDa centrosomal protein
centrosomal protein 192kDa
cep192/SPD-2
protein phosphatase 1, regulatory subunit 62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032142.4NP_115518.3  centrosomal protein of 192 kDa

    Status: VALIDATED

    Source sequence(s)
    AB046789, AK096548, AL833494, BC144481, BX648232, DB079620
    Consensus CDS
    CCDS32792.2
    UniProtKB/Swiss-Prot
    A0A060A9S4, B7ZMF0, E9PF99, Q8TEP8, Q8WYT8, Q9H0F4, Q9NW27
    UniProtKB/TrEMBL
    K7ENP4
    Related
    ENSP00000427550.1, ENST00000506447.5
    Conserved Domains (1) summary
    pfam08626
    Location:16771767
    TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    12991362..13125036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722326.4XP_006722389.1  centrosomal protein of 192 kDa isoform X2

    UniProtKB/TrEMBL
    K7ENP4
    Conserved Domains (1) summary
    cl13764
    Location:16601724
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  2. XM_005258107.4XP_005258164.1  centrosomal protein of 192 kDa isoform X1

    UniProtKB/TrEMBL
    K7ENP4
    Conserved Domains (1) summary
    cl13764
    Location:16601724
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  3. XM_047437562.1XP_047293518.1  centrosomal protein of 192 kDa isoform X3

    UniProtKB/TrEMBL
    K7ENP4
  4. XM_047437564.1XP_047293520.1  centrosomal protein of 192 kDa isoform X8

    UniProtKB/TrEMBL
    K7ENP4
  5. XM_011525673.3XP_011523975.1  centrosomal protein of 192 kDa isoform X4

    UniProtKB/TrEMBL
    K7ENP4
    Conserved Domains (1) summary
    cl13764
    Location:16601727
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  6. XM_047437565.1XP_047293521.1  centrosomal protein of 192 kDa isoform X9

    UniProtKB/TrEMBL
    K7ENP4
  7. XM_047437563.1XP_047293519.1  centrosomal protein of 192 kDa isoform X5

    UniProtKB/TrEMBL
    K7ENP4
  8. XM_047437566.1XP_047293522.1  centrosomal protein of 192 kDa isoform X10

    UniProtKB/TrEMBL
    K7ENP4
  9. XM_005258109.4XP_005258166.1  centrosomal protein of 192 kDa isoform X6

    UniProtKB/TrEMBL
    K7ENP4
    Conserved Domains (1) summary
    cl13764
    Location:15901654
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  10. XM_047437567.1XP_047293523.1  centrosomal protein of 192 kDa isoform X11

    UniProtKB/TrEMBL
    K7ENP4
  11. XM_006722327.4XP_006722390.1  centrosomal protein of 192 kDa isoform X7

    UniProtKB/TrEMBL
    K7ENP4
    Related
    ENSP00000317156.9, ENST00000325971.12
    Conserved Domains (1) summary
    cl13764
    Location:15901654
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  12. XM_047437568.1XP_047293524.1  centrosomal protein of 192 kDa isoform X13

    UniProtKB/TrEMBL
    K7ENP4
  13. XM_047437569.1XP_047293525.1  centrosomal protein of 192 kDa isoform X14

    UniProtKB/TrEMBL
    K7ENP4
  14. XM_006722330.4XP_006722393.1  centrosomal protein of 192 kDa isoform X20

    UniProtKB/TrEMBL
    A0A0A0MR42
    Conserved Domains (1) summary
    cl13764
    Location:13211385
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  15. XM_017025804.2XP_016881293.1  centrosomal protein of 192 kDa isoform X21

    UniProtKB/TrEMBL
    A0A0A0MR42
  16. XM_047437575.1XP_047293531.1  centrosomal protein of 192 kDa isoform X22

    UniProtKB/TrEMBL
    A0A0A0MR42
  17. XM_047437571.1XP_047293527.1  centrosomal protein of 192 kDa isoform X16

    UniProtKB/TrEMBL
    H0Y966
  18. XM_047437573.1XP_047293529.1  centrosomal protein of 192 kDa isoform X18

    UniProtKB/TrEMBL
    K7ENP4
  19. XM_047437570.1XP_047293526.1  centrosomal protein of 192 kDa isoform X15

    UniProtKB/TrEMBL
    H0Y966
  20. XM_047437572.1XP_047293528.1  centrosomal protein of 192 kDa isoform X17

    UniProtKB/TrEMBL
    H0Y966
  21. XM_047437576.1XP_047293532.1  centrosomal protein of 192 kDa isoform X23

  22. XM_047437579.1XP_047293535.1  centrosomal protein of 192 kDa isoform X26

    UniProtKB/TrEMBL
    K7ELX0
  23. XM_011525675.4XP_011523977.2  centrosomal protein of 192 kDa isoform X12

    UniProtKB/TrEMBL
    K7ENP4
    Conserved Domains (1) summary
    pfam08626
    Location:15871677
    TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
  24. XM_047437574.1XP_047293530.1  centrosomal protein of 192 kDa isoform X19

    UniProtKB/TrEMBL
    K7ENP4
    Related
    ENSP00000423147.1, ENST00000510237.5
  25. XM_047437577.1XP_047293533.1  centrosomal protein of 192 kDa isoform X24

    UniProtKB/TrEMBL
    A0A0A0MR42
    Related
    ENSP00000467038.1, ENST00000511820.6
  26. XM_047437578.1XP_047293534.1  centrosomal protein of 192 kDa isoform X25

    UniProtKB/TrEMBL
    A0A0A0MR42

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    13154097..13287771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318718.1XP_054174693.1  centrosomal protein of 192 kDa isoform X2

    UniProtKB/TrEMBL
    K7ENP4
  2. XM_054318717.1XP_054174692.1  centrosomal protein of 192 kDa isoform X1

    UniProtKB/TrEMBL
    K7ENP4
  3. XM_054318719.1XP_054174694.1  centrosomal protein of 192 kDa isoform X3

    UniProtKB/TrEMBL
    K7ENP4
  4. XM_054318724.1XP_054174699.1  centrosomal protein of 192 kDa isoform X8

    UniProtKB/TrEMBL
    K7ENP4
  5. XM_054318720.1XP_054174695.1  centrosomal protein of 192 kDa isoform X4

    UniProtKB/TrEMBL
    K7ENP4
  6. XM_054318725.1XP_054174700.1  centrosomal protein of 192 kDa isoform X9

    UniProtKB/TrEMBL
    K7ENP4
  7. XM_054318721.1XP_054174696.1  centrosomal protein of 192 kDa isoform X5

    UniProtKB/TrEMBL
    K7ENP4
  8. XM_054318726.1XP_054174701.1  centrosomal protein of 192 kDa isoform X10

    UniProtKB/TrEMBL
    K7ENP4
  9. XM_054318722.1XP_054174697.1  centrosomal protein of 192 kDa isoform X6

    UniProtKB/TrEMBL
    K7ENP4
  10. XM_054318727.1XP_054174702.1  centrosomal protein of 192 kDa isoform X11

    UniProtKB/TrEMBL
    K7ENP4
  11. XM_054318723.1XP_054174698.1  centrosomal protein of 192 kDa isoform X7

    UniProtKB/TrEMBL
    K7ENP4
  12. XM_054318729.1XP_054174704.1  centrosomal protein of 192 kDa isoform X13

    UniProtKB/TrEMBL
    K7ENP4
  13. XM_054318730.1XP_054174705.1  centrosomal protein of 192 kDa isoform X14

    UniProtKB/TrEMBL
    K7ENP4
  14. XM_054318736.1XP_054174711.1  centrosomal protein of 192 kDa isoform X20

    UniProtKB/TrEMBL
    A0A0A0MR42
  15. XM_054318737.1XP_054174712.1  centrosomal protein of 192 kDa isoform X21

    UniProtKB/TrEMBL
    A0A0A0MR42
  16. XM_054318738.1XP_054174713.1  centrosomal protein of 192 kDa isoform X22

    UniProtKB/TrEMBL
    A0A0A0MR42
  17. XM_054318732.1XP_054174707.1  centrosomal protein of 192 kDa isoform X16

    UniProtKB/TrEMBL
    H0Y966
  18. XM_054318734.1XP_054174709.1  centrosomal protein of 192 kDa isoform X18

    UniProtKB/TrEMBL
    K7ENP4
  19. XM_054318731.1XP_054174706.1  centrosomal protein of 192 kDa isoform X15

    UniProtKB/TrEMBL
    H0Y966
  20. XM_054318733.1XP_054174708.1  centrosomal protein of 192 kDa isoform X17

    UniProtKB/TrEMBL
    H0Y966
  21. XM_054318739.1XP_054174714.1  centrosomal protein of 192 kDa isoform X23

  22. XM_054318742.1XP_054174717.1  centrosomal protein of 192 kDa isoform X26

    UniProtKB/TrEMBL
    K7ELX0
  23. XM_054318728.1XP_054174703.1  centrosomal protein of 192 kDa isoform X12

    UniProtKB/TrEMBL
    K7ENP4
  24. XM_054318735.1XP_054174710.1  centrosomal protein of 192 kDa isoform X19

    UniProtKB/TrEMBL
    K7ENP4
  25. XM_054318740.1XP_054174715.1  centrosomal protein of 192 kDa isoform X24

    UniProtKB/TrEMBL
    A0A0A0MR42
  26. XM_054318741.1XP_054174716.1  centrosomal protein of 192 kDa isoform X25

    UniProtKB/TrEMBL
    A0A0A0MR42

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018069.2: Suppressed sequence

    Description
    NM_018069.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.