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TMEM39B transmembrane protein 39B [ Homo sapiens (human) ]

Gene ID: 55116, updated on 22-Sep-2022

Summary

Official Symbol
TMEM39Bprovided by HGNC
Official Full Name
transmembrane protein 39Bprovided by HGNC
Primary source
HGNC:HGNC:25510
See related
Ensembl:ENSG00000121775 AllianceGenome:HGNC:25510
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta (RPKM 2.8), testis (RPKM 2.8) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM39B in Genome Data Viewer
Location:
1p35.2
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (32072031..32102863)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (31929980..31960816)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32537632..32568464)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 15509 Neighboring gene Sharpr-MPRA regulatory region 7843 Neighboring gene microRNA 5585 Neighboring gene Sharpr-MPRA regulatory region 5670 Neighboring gene karyopherin subunit alpha 6 Neighboring gene taxilin alpha Neighboring gene coiled-coil domain containing 28B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10315

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319677.2NP_001306606.1  transmembrane protein 39B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, resulting in a different 5' UTR and use of a downstream in-frame start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK091861, AK300293
    UniProtKB/Swiss-Prot
    Q9GZU3
    UniProtKB/TrEMBL
    B3KRL9, Q9BT39, Q9NW51
    Related
    ENST00000487305.5
    Conserved Domains (1) summary
    pfam10271
    Location:1351
    Tmp39; Putative transmembrane protein
  2. NM_001319678.2NP_001306607.1  transmembrane protein 39B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (3), which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK298766, AL136695, DA614559
    UniProtKB/Swiss-Prot
    Q9GZU3
    UniProtKB/TrEMBL
    Q9BT39
    Conserved Domains (1) summary
    pfam10271
    Location:1279
    Tmp39; Putative transmembrane protein
  3. NM_001319679.2NP_001306608.1  transmembrane protein 39B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (3), which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    BC004364, DA614559
    UniProtKB/Swiss-Prot
    Q9GZU3
    UniProtKB/TrEMBL
    Q9BT39
    Conserved Domains (1) summary
    pfam10271
    Location:1279
    Tmp39; Putative transmembrane protein
  4. NM_018056.4NP_060526.2  transmembrane protein 39B isoform 1

    See identical proteins and their annotated locations for NP_060526.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK023331, BC004364
    Consensus CDS
    CCDS351.2
    UniProtKB/Swiss-Prot
    Q6IA44, Q9GZU3
    UniProtKB/TrEMBL
    Q9BT39
    Related
    ENSP00000338165.5, ENST00000336294.10
    Conserved Domains (1) summary
    pfam10271
    Location:51478
    Tmp39; Putative transmembrane protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    32072031..32102863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423840.1XP_047279796.1  transmembrane protein 39B isoform X1

  2. XM_006710725.5XP_006710788.1  transmembrane protein 39B isoform X3

    See identical proteins and their annotated locations for XP_006710788.1

    Conserved Domains (1) summary
    pfam10271
    Location:51414
    Tmp39; Putative transmembrane protein
  3. XM_006710724.3XP_006710787.1  transmembrane protein 39B isoform X2

    Conserved Domains (1) summary
    pfam10271
    Location:51414
    Tmp39; Putative transmembrane protein
  4. XM_047423846.1XP_047279802.1  transmembrane protein 39B isoform X4

  5. XM_047423842.1XP_047279798.1  transmembrane protein 39B isoform X4

  6. XM_005270988.3XP_005271045.1  transmembrane protein 39B isoform X6

    See identical proteins and their annotated locations for XP_005271045.1

    UniProtKB/TrEMBL
    Q9NW51
    Conserved Domains (1) summary
    pfam10271
    Location:1351
    Tmp39; Putative transmembrane protein
  7. XM_047423852.1XP_047279808.1  transmembrane protein 39B isoform X8

  8. XM_011541683.2XP_011539985.1  transmembrane protein 39B isoform X6

    See identical proteins and their annotated locations for XP_011539985.1

    UniProtKB/TrEMBL
    Q9NW51
    Conserved Domains (1) summary
    pfam10271
    Location:1351
    Tmp39; Putative transmembrane protein
  9. XM_017001595.2XP_016857084.1  transmembrane protein 39B isoform X5

    Conserved Domains (1) summary
    pfam10271
    Location:3363
    Tmp39; Putative transmembrane protein
  10. XM_047423851.1XP_047279807.1  transmembrane protein 39B isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    31929980..31960816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)