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NTAQ1 N-terminal glutamine amidase 1 [ Homo sapiens (human) ]

Gene ID: 55093, updated on 23-Nov-2021

Summary

Official Symbol
NTAQ1provided by HGNC
Official Full Name
N-terminal glutamine amidase 1provided by HGNC
Primary source
HGNC:HGNC:25490
See related
Ensembl:ENSG00000156795
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WDYHV1; C8orf32
Expression
Ubiquitous expression in testis (RPKM 1.6), ovary (RPKM 1.2) and 25 other tissues See more
Orthologs
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Genomic context

See NTAQ1 in Genome Data Viewer
Location:
8q24.13
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (123416701..123467527)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (124428965..124460331)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375737 Neighboring gene inosine monophosphate dehydrogenase 1 pseudogene 6 Neighboring gene F-box protein 32 Neighboring gene RN7SK pseudogene 155

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10204

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-N-terminal asparagine amidohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-N-terminal glutamine amidohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-N-terminal glutamine amidohydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cellular protein modification process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular protein modification process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein N-terminal glutamine amidohydrolase
Names
N-terminal Gln amidase
WDYHV motif containing 1
WDYHV motif-containing protein 1
nt(Q)-amidase
protein NH2-terminal glutamine deamidase
NP_001269953.1
NP_001269956.1
NP_060494.1
XP_006716660.1
XP_011515453.1
XP_016869090.1
XP_016869091.1
XP_016869092.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001283024.1NP_001269953.1  protein N-terminal glutamine amidohydrolase isoform 2

    See identical proteins and their annotated locations for NP_001269953.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR which results in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC021305, AK293492
    Consensus CDS
    CCDS64965.1
    UniProtKB/Swiss-Prot
    Q96HA8
    Related
    ENSP00000430427.1, ENST00000523984.5
    Conserved Domains (1) summary
    pfam09764
    Location:1132
    Nt_Gln_amidase; N-terminal glutamine amidase
  2. NM_001283027.1NP_001269956.1  protein N-terminal glutamine amidohydrolase isoform 3

    See identical proteins and their annotated locations for NP_001269956.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and has an alternate internal exon compared to variant 1. These differences cause translation initiation at a alternate start codon compared to variant 1. The encoded isoform (3) is shorter and has a disntinct N-teminus compared to isoform 1.
    Source sequence(s)
    AC021305, AU119047, BG528966
    Conserved Domains (1) summary
    pfam09764
    Location:11124
    Nt_Gln_amidase; N-terminal glutamine amidase
  3. NM_018024.3NP_060494.1  protein N-terminal glutamine amidohydrolase isoform 1

    See identical proteins and their annotated locations for NP_060494.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC021305, AK001066
    Consensus CDS
    CCDS6344.1
    UniProtKB/Swiss-Prot
    Q96HA8
    Related
    ENSP00000287387.2, ENST00000287387.7
    Conserved Domains (1) summary
    pfam09764
    Location:23192
    Nt_Gln_amidase; N-terminal glutamine amidase

RNA

  1. NR_133926.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in an internal exon and includes an alternate 3' terminal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC021305, AK001066, AL528914

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    123416701..123467527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013601.1XP_016869090.1  protein N-terminal glutamine amidohydrolase isoform X1

  2. XM_006716597.3XP_006716660.1  protein N-terminal glutamine amidohydrolase isoform X2

    UniProtKB/TrEMBL
    E5RHC2
    Related
    ENSP00000428615.1, ENST00000523356.1
    Conserved Domains (1) summary
    pfam09764
    Location:23182
    Nt_Gln_amidase; N-terminal glutamine amidase
  3. XM_017013602.1XP_016869091.1  protein N-terminal glutamine amidohydrolase isoform X3

    Related
    ENSP00000497747.1, ENST00000650311.1
  4. XM_017013603.1XP_016869092.1  protein N-terminal glutamine amidohydrolase isoform X5

    Related
    ENSP00000497798.1, ENST00000523551.1
  5. XM_011517151.2XP_011515453.1  protein N-terminal glutamine amidohydrolase isoform X4

    See identical proteins and their annotated locations for XP_011515453.1

    Conserved Domains (1) summary
    pfam09764
    Location:11124
    Nt_Gln_amidase; N-terminal glutamine amidase

RNA

  1. XR_002956636.1 RNA Sequence

  2. XR_002956635.1 RNA Sequence

  3. XR_928337.3 RNA Sequence

  4. XR_002956634.1 RNA Sequence

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