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TMEM51 transmembrane protein 51 [ Homo sapiens (human) ]

Gene ID: 55092, updated on 6-Oct-2019

Summary

Official Symbol
TMEM51provided by HGNC
Official Full Name
transmembrane protein 51provided by HGNC
Primary source
HGNC:HGNC:25488
See related
Ensembl:ENSG00000171729
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1orf72
Expression
Ubiquitous expression in urinary bladder (RPKM 10.5), gall bladder (RPKM 9.1) and 24 other tissues See more
Orthologs

Genomic context

See TMEM51 in Genome Data Viewer
Location:
1p36.21
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (15152418..15220478)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (15479028..15546974)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene kazrin, periplakin interacting protein Neighboring gene uncharacterized LOC107985469 Neighboring gene Sharpr-MPRA regulatory region 2794 Neighboring gene TMEM51 antisense RNA 1 Neighboring gene mitochondrial fission factor pseudogene Neighboring gene zinc finger and BTB domain containing 2 pseudogene Neighboring gene chromosome 1 open reading frame 195 Neighboring gene forkhead associated phosphopeptide binding domain 1 Neighboring gene FHAD1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10199

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136216.2NP_001129688.1  transmembrane protein 51 isoform 1

    See identical proteins and their annotated locations for NP_001129688.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 4 encode the same isoform (1)
    Source sequence(s)
    AL035405, AL391094
    Consensus CDS
    CCDS154.1
    UniProtKB/Swiss-Prot
    Q9NW97
    UniProtKB/TrEMBL
    A0A024QZ97
    Related
    ENSP00000365182.3, ENST00000376014.7
    Conserved Domains (1) summary
    pfam15345
    Location:7240
    TMEM51; Transmembrane protein 51
  2. NM_001136217.1NP_001129689.1  transmembrane protein 51 isoform 1

    See identical proteins and their annotated locations for NP_001129689.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same isoform (1).
    Source sequence(s)
    AK292184, AL525184, BC000593, BM310196, DC295166, DC345032
    Consensus CDS
    CCDS154.1
    UniProtKB/Swiss-Prot
    Q9NW97
    UniProtKB/TrEMBL
    A0A024QZ97
    Related
    ENSP00000394899.1, ENST00000428417.5
    Conserved Domains (1) summary
    pfam15345
    Location:7240
    TMEM51; Transmembrane protein 51
  3. NM_001136218.2NP_001129690.1  transmembrane protein 51 isoform 1

    See identical proteins and their annotated locations for NP_001129690.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same isoform (1).
    Source sequence(s)
    AL035405, AL391094
    Consensus CDS
    CCDS154.1
    UniProtKB/Swiss-Prot
    Q9NW97
    UniProtKB/TrEMBL
    A0A024QZ97
    Related
    ENSP00000365176.1, ENST00000376008.3
    Conserved Domains (1) summary
    pfam15345
    Location:7240
    TMEM51; Transmembrane protein 51
  4. NM_001319665.2NP_001306594.1  transmembrane protein 51 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, resulting in a frameshift and an early start codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL035405, AL391094
    Consensus CDS
    CCDS81266.1
    UniProtKB/Swiss-Prot
    Q9NW97
    UniProtKB/TrEMBL
    Q9BSA0
    Related
    ENSP00000409665.2, ENST00000434578.6
    Conserved Domains (1) summary
    pfam15345
    Location:7114
    TMEM51; Transmembrane protein 51
  5. NM_018022.3NP_060492.1  transmembrane protein 51 isoform 1

    See identical proteins and their annotated locations for NP_060492.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same isoform (1)
    Source sequence(s)
    AL035405, AL391094
    Consensus CDS
    CCDS154.1
    UniProtKB/Swiss-Prot
    Q9NW97
    UniProtKB/TrEMBL
    A0A024QZ97
    Related
    ENSP00000383600.2, ENST00000400796.7
    Conserved Domains (1) summary
    pfam15345
    Location:7240
    TMEM51; Transmembrane protein 51

RNA

  1. NR_135082.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL035405, AL391094

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    15152418..15220478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001590.1XP_016857079.1  transmembrane protein 51 isoform X1

    UniProtKB/Swiss-Prot
    Q9NW97
    UniProtKB/TrEMBL
    A0A024QZ97
    Conserved Domains (1) summary
    pfam15345
    Location:7240
    TMEM51; Transmembrane protein 51
  2. XM_011541676.1XP_011539978.1  transmembrane protein 51 isoform X1

    See identical proteins and their annotated locations for XP_011539978.1

    UniProtKB/Swiss-Prot
    Q9NW97
    UniProtKB/TrEMBL
    A0A024QZ97
    Conserved Domains (1) summary
    pfam15345
    Location:7240
    TMEM51; Transmembrane protein 51
  3. XM_005245919.1XP_005245976.1  transmembrane protein 51 isoform X1

    See identical proteins and their annotated locations for XP_005245976.1

    UniProtKB/Swiss-Prot
    Q9NW97
    UniProtKB/TrEMBL
    A0A024QZ97
    Conserved Domains (1) summary
    pfam15345
    Location:7240
    TMEM51; Transmembrane protein 51
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