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SLC38A4 solute carrier family 38 member 4 [ Homo sapiens (human) ]

Gene ID: 55089, updated on 13-Mar-2020

Summary

Official Symbol
SLC38A4provided by HGNC
Official Full Name
solute carrier family 38 member 4provided by HGNC
Primary source
HGNC:HGNC:14679
See related
Ensembl:ENSG00000139209 MIM:608065
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATA3; NAT3; PAAT; SNAT4
Summary
SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids. The transport of cationic amino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral amino acids is Na(+) and pH dependent (Hatanaka et al., 2001 [PubMed 11342143]).[supplied by OMIM, Mar 2008]
Expression
Restricted expression toward liver (RPKM 138.1) See more
Orthologs

Genomic context

See SLC38A4 in Genome Data Viewer
Location:
12q13.11
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (46764761..46832422, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (47158544..47226205, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100288798 Neighboring gene olfactory receptor family 7 subfamily A member 19 pseudogene Neighboring gene microtubule affinity regulating kinase 3 pseudogene 1 Neighboring gene uncharacterized LOC107984466 Neighboring gene adhesion molecule with Ig like domain 2 Neighboring gene PC-esterase domain containing 1B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10191, MGC126876

Gene Ontology Provided by GOA

Function Evidence Code Pubs
amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amino acid transmembrane transporter activity TAS
Traceable Author Statement
more info
 
symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amino acid transport TAS
Traceable Author Statement
more info
 
sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sodium-coupled neutral amino acid transporter 4
Names
N amino acid transporter 3
Na(+)-coupled neutral amino acid transporter 4
amino acid transporter A3
amino acid transporter system A3
system A amino acid transporter 3
system N amino acid transporter 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143824.2NP_001137296.1  sodium-coupled neutral amino acid transporter 4

    See identical proteins and their annotated locations for NP_001137296.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC008014, AC080136, KF459548
    Consensus CDS
    CCDS8750.1
    UniProtKB/Swiss-Prot
    Q969I6
    UniProtKB/TrEMBL
    A0A024R0X7
    Related
    ENSP00000389843.1, ENST00000447411.5
    Conserved Domains (2) summary
    COG0814
    Location:71534
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    cl00456
    Location:73535
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. NM_018018.5NP_060488.2  sodium-coupled neutral amino acid transporter 4

    See identical proteins and their annotated locations for NP_060488.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC008014, AC080136, KF459548
    Consensus CDS
    CCDS8750.1
    UniProtKB/Swiss-Prot
    Q969I6
    UniProtKB/TrEMBL
    A0A024R0X7
    Related
    ENSP00000266579.4, ENST00000266579.9
    Conserved Domains (2) summary
    COG0814
    Location:71534
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    cl00456
    Location:73535
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    46764761..46832422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268997.2XP_005269054.1  sodium-coupled neutral amino acid transporter 4 isoform X1

    See identical proteins and their annotated locations for XP_005269054.1

    UniProtKB/Swiss-Prot
    Q969I6
    UniProtKB/TrEMBL
    A0A024R0X7
    Conserved Domains (2) summary
    COG0814
    Location:71534
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    cl00456
    Location:73535
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
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