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RADX RPA1 related single stranded DNA binding protein, X-linked [ Homo sapiens (human) ]

Gene ID: 55086, updated on 9-Jun-2025
Official Symbol
RADXprovided by HGNC
Official Full Name
RPA1 related single stranded DNA binding protein, X-linkedprovided by HGNC
Primary source
HGNC:HGNC:25486
See related
Ensembl:ENSG00000147231 MIM:301146; AllianceGenome:HGNC:25486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CXorf57
Summary
Enables single-stranded DNA binding activity. Involved in negative regulation of double-strand break repair via homologous recombination. Located in nuclear speck and replication fork. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Broad expression in adrenal (RPKM 4.5), ovary (RPKM 4.0) and 24 other tissues See more
Orthologs
mouse all
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See RADX in Genome Data Viewer
Location:
Xq22.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (106611978..106679439)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (105048421..105115882)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (105855208..105922669)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29827 Neighboring gene nucleosome assembly protein 1 like 4 pseudogene 2 Neighboring gene serpin family A member 7 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29829 Neighboring gene microRNA 548an Neighboring gene uncharacterized LOC124905235 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:105969778-105970366 Neighboring gene ring finger protein 128 Neighboring gene TBC1 domain family member 8B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29830

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. RADX interacts with single-stranded DNA to promote replication fork stability. Schubert L, et al. EMBO Rep, 2017 Nov. PMID 29021206, Free PMC Article
  2. Oligomerization of DNA replication regulatory protein RADX is essential to maintain replication fork stability. Mohamed T, et al. J Biol Chem, 2022 Mar. PMID 35120927, Free PMC Article
  3. RADX Modulates RAD51 Activity to Control Replication Fork Protection. Bhat KP, et al. Cell Rep, 2018 Jul 17. PMID 30021152, Free PMC Article
  4. RADX controls RAD51 filament dynamics to regulate replication fork stability. Adolph MB, et al. Mol Cell, 2021 Mar 4. PMID 33453169, Free PMC Article
  5. RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks. Dungrawala H, et al. Mol Cell, 2017 Aug 3. PMID 28735897, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Oligomerization of DNA replication regulatory protein RADX is essential to maintain replication fork stability.
    Title: Oligomerization of DNA replication regulatory protein RADX is essential to maintain replication fork stability.
  2. RADX controls RAD51 filament dynamics to regulate replication fork stability.
    Title: RADX controls RAD51 filament dynamics to regulate replication fork stability.
  3. RADX buffers RAD51 to ensure the right amount of reversal and protection to maintain genome stability.
    Title: RADX Modulates RAD51 Activity to Control Replication Fork Protection.
  4. RADX interacts with single-stranded DNA to promote replication fork stability.
    Title: RADX interacts with single-stranded DNA to promote replication fork stability.
  5. By antagonizing RAD51 at forks, RADX allows cells to maintain a high capacity for homology-directed repair while ensuring that replication functions of RAD51 are properly regulated. Thus, RADX is essential to achieve the proper balance of RAD51 activity to maintain genome stability.
    Title: RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks.
Submit: New GeneRIF Correction

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ10178, FLJ14191

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
is_active_in replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in replication fork IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
RPA-related protein RADX
Names
RPA-related and RAD51-antagonist, X-chromosome
RPA-related, RAD51-antagonist on X-chromosome
uncharacterized protein CXorf57

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021317.1 RefSeqGene

    Range
    5049..72510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184782.2 → NP_001171711.1  RPA-related protein RADX isoform 2

    See identical proteins and their annotated locations for NP_001171711.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK024253, AL606833, BC047503, BC070110, DB065928
    Consensus CDS
    CCDS55470.1
    UniProtKB/TrEMBL
    A8K6R5
    Related
    ENSP00000361623.2, ENST00000372544.6
    Conserved Domains (1) summary
    cl28407
    Location:95 → 412
    RFA1; ssDNA-binding replication factor A, large subunit [Replication, recombination and repair]

  2. NM_018015.6 → NP_060485.4  RPA-related protein RADX isoform 1

    See identical proteins and their annotated locations for NP_060485.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC011483, BC047503, BC070110
    Consensus CDS
    CCDS14519.1
    UniProtKB/Swiss-Prot
    H7BY89, Q4G0L7, Q5JQS1, Q5JRF9, Q6NSI4, Q6PHY5, Q6PII9, Q6PJU8, Q9H7W5, Q9NWA6
    UniProtKB/TrEMBL
    A8K6R5
    Related
    ENSP00000361628.4, ENST00000372548.9
    Conserved Domains (1) summary
    pfam17659
    Location:2 → 849
    DUF5521; Family of unknown function (DUF5521)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    106611978..106679439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442233.1 → XP_047298189.1  RPA-related protein RADX isoform X1

    Related
    ENSP00000432238.1, ENST00000461251.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    105048421..105115882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327345.1 → XP_054183320.1  RPA-related protein RADX isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NSI4.2 GenPept UniProtKB/Swiss-Prot:Q6NSI4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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