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TAPBPL TAP binding protein like [ Homo sapiens (human) ]

Gene ID: 55080, updated on 5-Aug-2018

Summary

Official Symbol
TAPBPLprovided by HGNC
Official Full Name
TAP binding protein likeprovided by HGNC
Primary source
HGNC:HGNC:30683
See related
Ensembl:ENSG00000139192 MIM:607081; Vega:OTTHUMG00000168317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAPBPR; TAPBP-R
Summary
Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in duodenum (RPKM 8.1), small intestine (RPKM 7.3) and 25 other tissues See more
Orthologs

Genomic context

See TAPBPL in Genome Data Viewer
Location:
12p13.31
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (6451656..6472006)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6561177..6571488)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 10 Neighboring gene CD27 antisense RNA 1 Neighboring gene signal recognition particle 14 pseudogene 1 Neighboring gene CD27 molecule Neighboring gene vesicle associated membrane protein 1 Neighboring gene plakophilin 2 pseudogene 1 Neighboring gene mitochondrial ribosomal protein L51

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with TAPBPL; predicted interaction to be involved in antigenicity/immunity PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10143

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
immune system process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of antigen processing and presentation of peptide antigen via MHC class I IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tapasin-related protein
Names
TAP binding protein related
TAP-binding protein-related protein
TAPASIN-R
tapasin-like

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351355.1NP_001338284.1  tapasin-related protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC005840
    Conserved Domains (2) summary
    cd05771
    Location:136266
    IgC_Tapasin_R; Tapasin-R immunoglobulin-like domain
    cl11960
    Location:74170
    Ig; Immunoglobulin domain
  2. NM_018009.4NP_060479.3  tapasin-related protein precursor

    See identical proteins and their annotated locations for NP_060479.3

    Status: VALIDATED

    Source sequence(s)
    AI184901, AI273155, BC015017, CR997450, DB054664
    Consensus CDS
    CCDS8546.1
    UniProtKB/Swiss-Prot
    Q9BX59
    Related
    ENSP00000266556.7, OTTHUMP00000238559, ENST00000266556.7, OTTHUMT00000399263
    Conserved Domains (3) summary
    cd05771
    Location:266396
    IgC_Tapasin_R; Tapasin-R immunoglobulin-like domain
    smart00410
    Location:198300
    IG_like; Immunoglobulin like
    cl11960
    Location:204300
    Ig; Immunoglobulin domain

RNA

  1. NR_147126.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005840
    Related
    ENST00000539384.5
  2. NR_147127.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005840
  3. NR_147128.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005840
  4. NR_147129.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005840

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    6451656..6472006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019546.2XP_016875035.1  tapasin-related protein isoform X2

    Conserved Domains (2) summary
    cd05771
    Location:136266
    IgC_Tapasin_R; Tapasin-R immunoglobulin-like domain
    cl11960
    Location:74170
    Ig; Immunoglobulin domain
  2. XM_005253700.4XP_005253757.1  tapasin-related protein isoform X1

    Conserved Domains (3) summary
    cd05771
    Location:266396
    IgC_Tapasin_R; Tapasin-R immunoglobulin-like domain
    smart00410
    Location:198300
    IG_like; Immunoglobulin like
    cl11960
    Location:204300
    Ig; Immunoglobulin domain
  3. XM_017019545.1XP_016875034.1  tapasin-related protein isoform X2

    Conserved Domains (2) summary
    cd05771
    Location:136266
    IgC_Tapasin_R; Tapasin-R immunoglobulin-like domain
    cl11960
    Location:74170
    Ig; Immunoglobulin domain

RNA

  1. XR_001748777.2 RNA Sequence

  2. XR_001748778.2 RNA Sequence

  3. XR_002957344.1 RNA Sequence

  4. XR_001748781.2 RNA Sequence

  5. XR_429016.3 RNA Sequence

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