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FEZF2 FEZ family zinc finger 2 [ Homo sapiens (human) ]

Gene ID: 55079, updated on 11-Jun-2021

Summary

Official Symbol
FEZF2provided by HGNC
Official Full Name
FEZ family zinc finger 2provided by HGNC
Primary source
HGNC:HGNC:13506
See related
Ensembl:ENSG00000153266 MIM:607414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FEZ; TOF; FEZL; FKSG36; ZFP312; ZNF312
Expression
Restricted expression toward brain (RPKM 4.1) See more
Orthologs
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Genomic context

See FEZF2 in Genome Data Viewer
Location:
3p14.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (62369681..62373550, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (62355356..62359225, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9750 Neighboring gene VISTA enhancer hs434 Neighboring gene VISTA enhancer hs435 Neighboring gene uncharacterized LOC105377647 Neighboring gene VISTA enhancer hs1316 Neighboring gene calcium dependent secretion activator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of FEZ family zinc finger 2 (FEZF2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10142

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in axonal fasciculation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell dedifferentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebral cortex GABAergic interneuron migration IEA
Inferred from Electronic Annotation
more info
 
involved_in commitment of neuronal cell to specific neuron type in forebrain IEA
Inferred from Electronic Annotation
more info
 
involved_in dendrite development IEA
Inferred from Electronic Annotation
more info
 
involved_in dentate gyrus development IEA
Inferred from Electronic Annotation
more info
 
involved_in forebrain anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
involved_in locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron fate determination IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
fez family zinc finger protein 2
Names
forebrain embryonic zinc finger-like protein 2
testis tissue sperm-binding protein Li 80P
too few
zinc finger protein 312

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018008.4NP_060478.3  fez family zinc finger protein 2

    See identical proteins and their annotated locations for NP_060478.3

    Status: VALIDATED

    Source sequence(s)
    AC092502, BC022464, BM930804, DA492936, DR002892, H28929
    Consensus CDS
    CCDS2897.1
    UniProtKB/Swiss-Prot
    Q8TBJ5
    UniProtKB/TrEMBL
    A0A140VKG3
    Related
    ENSP00000283268.3, ENST00000283268.8
    Conserved Domains (3) summary
    COG5048
    Location:289395
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:385441
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:279299
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    62369681..62373550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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