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PDPR pyruvate dehydrogenase phosphatase regulatory subunit [ Homo sapiens (human) ]

Gene ID: 55066, updated on 17-Sep-2022

Summary

Official Symbol
PDPRprovided by HGNC
Official Full Name
pyruvate dehydrogenase phosphatase regulatory subunitprovided by HGNC
Primary source
HGNC:HGNC:30264
See related
Ensembl:ENSG00000090857 MIM:617835; AllianceGenome:HGNC:30264
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDP3
Summary
Pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate and links glycolysis to the tricarboxylic acid cycle and fatty acid synthesis. The dephosphorylation and reactivation of PDC is catalyzed by pyruvate dehydrogenase phosphatase (PDP). The dimeric PDP has a catalytic subunit and a regulatory subunit. This gene encodes the FAD-containing regulatory subunit of PDP. The encoded protein acts to decrease the sensitivity of the PDP catalytic subunit to magnesium ions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
Expression
Ubiquitous expression in testis (RPKM 9.0), brain (RPKM 8.9) and 25 other tissues See more
Orthologs
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Genomic context

See PDPR in Genome Data Viewer
Location:
16q22.1
Exon count:
23
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (70113626..70163427)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (80365322..80415407, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70147529..70196440)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903706 Neighboring gene ribosomal protein S10 pseudogene 24 Neighboring gene uncharacterized LOC400541 Neighboring gene C-type lectin domain family 18 member C Neighboring gene uncharacterized LOC105371328

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10079, DKFZp686A088, DKFZp686D16130

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IC
Inferred by Curator
more info
PubMed 
part_of pyruvate dehydrogenase (lipoamide) phosphatase complex IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
NP_001309046.1
NP_001309047.1
NP_001309048.1
NP_060460.4
XP_005256072.1
XP_005256073.1
XP_006721287.1
XP_006721288.1
XP_011521492.1
XP_016878877.1
XP_047290258.1
XP_047290259.1
XP_047290260.1
XP_047290261.1
XP_047290262.1
XP_047290263.1
XP_047290264.1
XP_047290265.1
XP_047290266.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052842.1 RefSeqGene

    Range
    5707..53912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322117.1NP_001309046.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC009022, AC009060
    Consensus CDS
    CCDS45520.1
    UniProtKB/Swiss-Prot
    Q6AWC9, Q8NCN5
    Related
    ENSP00000457916.1, ENST00000568530.5
    Conserved Domains (4) summary
    COG0665
    Location:39426
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:463736
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:786852
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:405459
    FAO_M; FAD dependent oxidoreductase central domain
  2. NM_001322118.1NP_001309047.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009022, AC009060, AK302987
    Consensus CDS
    CCDS82007.1
    UniProtKB/TrEMBL
    A8MT40, B4DZL5
    Related
    ENSP00000381190.3, ENST00000398122.7
    Conserved Domains (5) summary
    COG0404
    Location:353730
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:1326
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:363636
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:648752
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:305360
    FAO_M; FAD dependent oxidoreductase central domain
  3. NM_001322119.1NP_001309048.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC009022, AC009060
    Conserved Domains (4) summary
    COG0404
    Location:51428
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    pfam01571
    Location:61334
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:346450
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:358
    FAO_M; FAD dependent oxidoreductase central domain
  4. NM_017990.5NP_060460.4  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_060460.4

    Status: REVIEWED

    Source sequence(s)
    AC009022, AC009060
    Consensus CDS
    CCDS45520.1
    UniProtKB/Swiss-Prot
    Q6AWC9, Q8NCN5
    Related
    ENSP00000288050.5, ENST00000288050.9
    Conserved Domains (4) summary
    COG0665
    Location:39426
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:463736
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:786852
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:405459
    FAO_M; FAD dependent oxidoreductase central domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    70113626..70163427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023388.3XP_016878877.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X5

    Related
    ENST00000561920.5
  2. XM_047434302.1XP_047290258.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q6AWC9
    Conserved Domains (4) summary
    COG0665
    Location:39426
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:463736
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:786852
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:405459
    FAO_M; FAD dependent oxidoreductase central domain
  3. XM_047434303.1XP_047290259.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X2

  4. XM_047434304.1XP_047290260.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X3

  5. XM_047434306.1XP_047290262.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X4

  6. XM_005256015.3XP_005256072.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005256072.1

    UniProtKB/Swiss-Prot
    Q6AWC9, Q8NCN5
    Conserved Domains (4) summary
    COG0665
    Location:39426
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:463736
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:786852
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:405459
    FAO_M; FAD dependent oxidoreductase central domain
  7. XM_006721224.3XP_006721287.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X2

    Conserved Domains (6) summary
    COG0404
    Location:453769
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:39426
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:463684
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:687791
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:405460
    FAO_M; FAD dependent oxidoreductase central domain
    cl21454
    Location:574
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  8. XM_006721225.4XP_006721288.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X3

    Conserved Domains (6) summary
    COG0404
    Location:373750
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:39346
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:383656
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:668772
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:325380
    FAO_M; FAD dependent oxidoreductase central domain
    cl21454
    Location:574
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  9. XM_047434305.1XP_047290261.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X4

  10. XM_011523190.4XP_011521492.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X6

    Conserved Domains (5) summary
    COG0404
    Location:453655
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:39426
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:463655
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam16350
    Location:405460
    FAO_M; FAD dependent oxidoreductase central domain
    cl21454
    Location:574
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  11. XM_047434310.1XP_047290266.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X9

    UniProtKB/TrEMBL
    H3BQG3
    Related
    ENSP00000455764.1, ENST00000565186.5
  12. XM_047434307.1XP_047290263.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X4

  13. XM_005256016.4XP_005256073.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005256073.1

    UniProtKB/Swiss-Prot
    Q6AWC9, Q8NCN5
    Conserved Domains (4) summary
    COG0665
    Location:39426
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:463736
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:786852
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:405459
    FAO_M; FAD dependent oxidoreductase central domain
  14. XM_047434308.1XP_047290264.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X7

  15. XM_047434309.1XP_047290265.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X8

RNA

  1. XR_007064891.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    80365322..80415407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)