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PDPR pyruvate dehydrogenase phosphatase regulatory subunit [ Homo sapiens (human) ]

Gene ID: 55066, updated on 20-Dec-2019

Summary

Official Symbol
PDPRprovided by HGNC
Official Full Name
pyruvate dehydrogenase phosphatase regulatory subunitprovided by HGNC
Primary source
HGNC:HGNC:30264
See related
Ensembl:ENSG00000090857 MIM:617835
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDP3
Summary
Pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate and links glycolysis to the tricarboxylic acid cycle and fatty acid synthesis. The dephosphorylation and reactivation of PDC is catalyzed by pyruvate dehydrogenase phosphatase (PDP). The dimeric PDP has a catalytic subunit and a regulatory subunit. This gene encodes the FAD-containing regulatory subunit of PDP. The encoded protein acts to decrease the sensitivity of the PDP catalytic subunit to magnesium ions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
Expression
Ubiquitous expression in testis (RPKM 9.0), brain (RPKM 8.9) and 25 other tissues See more
Orthologs

Genomic context

See PDPR in Genome Data Viewer
Location:
16q22.1
Exon count:
24
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (70113626..70163631)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70147529..70196437)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene nuclear pore complex-interacting protein Neighboring gene pyridoxal dependent decarboxylase domain containing 2, pseudogene Neighboring gene microRNA 1972-2 Neighboring gene ribosomal protein S10 pseudogene 24 Neighboring gene uncharacterized LOC400541 Neighboring gene uncharacterized LOC105371328 Neighboring gene C-type lectin domain family 18 member C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10079, DKFZp686A088, DKFZp686D16130

Gene Ontology Provided by GOA

Function Evidence Code Pubs
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
regulation of acetyl-CoA biosynthetic process from pyruvate TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
NP_001309046.1
NP_001309047.1
NP_001309048.1
NP_060460.4
XP_005256072.1
XP_005256073.1
XP_006721287.1
XP_006721288.1
XP_011521492.1
XP_016878876.1
XP_016878877.1
XP_016878878.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052842.1 RefSeqGene

    Range
    5001..53912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322117.1NP_001309046.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC009022, AC009060
    Consensus CDS
    CCDS45520.1
    UniProtKB/Swiss-Prot
    Q8NCN5
    Related
    ENSP00000457916.1, ENST00000568530.5
    Conserved Domains (6) summary
    COG0404
    Location:453830
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:39426
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:463736
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:748852
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:405460
    FAO_M; FAD dependent oxidoreductase central domain
    cl21454
    Location:574
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_001322118.1NP_001309047.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009022, AC009060, AK302987
    Consensus CDS
    CCDS82007.1
    UniProtKB/TrEMBL
    A8MT40, B4DZL5
    Related
    ENSP00000381190.3, ENST00000398122.7
    Conserved Domains (5) summary
    COG0404
    Location:353730
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:1326
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:363636
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:648752
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:305360
    FAO_M; FAD dependent oxidoreductase central domain
  3. NM_001322119.1NP_001309048.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC009022, AC009060
    Conserved Domains (4) summary
    COG0404
    Location:51428
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    pfam01571
    Location:61334
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:346450
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:358
    FAO_M; FAD dependent oxidoreductase central domain
  4. NM_017990.5NP_060460.4  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_060460.4

    Status: REVIEWED

    Source sequence(s)
    AC009022, AC009060
    Consensus CDS
    CCDS45520.1
    UniProtKB/Swiss-Prot
    Q8NCN5
    Related
    ENSP00000288050.4, ENST00000288050.8
    Conserved Domains (6) summary
    COG0404
    Location:453830
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:39426
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:463736
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:748852
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:405460
    FAO_M; FAD dependent oxidoreductase central domain
    cl21454
    Location:574
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    70113626..70163631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023388.2XP_016878877.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X4

  2. XM_005256015.2XP_005256072.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005256072.1

    UniProtKB/Swiss-Prot
    Q8NCN5
    Conserved Domains (6) summary
    COG0404
    Location:453830
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:39426
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:463736
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:748852
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:405460
    FAO_M; FAD dependent oxidoreductase central domain
    cl21454
    Location:574
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. XM_006721224.2XP_006721287.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X2

    Conserved Domains (6) summary
    COG0404
    Location:453769
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:39426
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:463684
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:687791
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:405460
    FAO_M; FAD dependent oxidoreductase central domain
    cl21454
    Location:574
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. XM_006721225.3XP_006721288.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X3

    Conserved Domains (6) summary
    COG0404
    Location:373750
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:39346
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:383656
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:668772
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:325380
    FAO_M; FAD dependent oxidoreductase central domain
    cl21454
    Location:574
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. XM_011523190.3XP_011521492.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X5

    Conserved Domains (5) summary
    COG0404
    Location:453655
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:39426
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:463655
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam16350
    Location:405460
    FAO_M; FAD dependent oxidoreductase central domain
    cl21454
    Location:574
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  6. XM_017023389.1XP_016878878.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X6

    Conserved Domains (5) summary
    COG0404
    Location:181558
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:9154
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:191464
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:476580
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:133188
    FAO_M; FAD dependent oxidoreductase central domain
  7. XM_017023387.1XP_016878876.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q8NCN5
    Conserved Domains (6) summary
    COG0404
    Location:453830
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:39426
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:463736
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:748852
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:405460
    FAO_M; FAD dependent oxidoreductase central domain
    cl21454
    Location:574
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  8. XM_005256016.3XP_005256073.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005256073.1

    UniProtKB/Swiss-Prot
    Q8NCN5
    Conserved Domains (6) summary
    COG0404
    Location:453830
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:39426
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:463736
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:748852
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:405460
    FAO_M; FAD dependent oxidoreductase central domain
    cl21454
    Location:574
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. XR_429721.2 RNA Sequence

  2. XR_001751950.1 RNA Sequence

  3. XR_001751949.1 RNA Sequence

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