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mhc1laa major histocompatibility complex class I LAA [ Danio rerio (zebrafish) ]

Gene ID: 550603, updated on 9-Dec-2024

Summary

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Official Symbol
mhc1laaprovided by ZNC
Official Full Name
major histocompatibility complex class I LAAprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-464
See related
Ensembl:ENSDARG00000016056 AllianceGenome:ZFIN:ZDB-GENE-050417-464
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:113060; CH73-211L2.2
Summary
Predicted to be involved in immune response. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in prostate carcinoma and pulmonary tuberculosis. Orthologous to several human genes including CD1A (CD1a molecule); CD1B (CD1b molecule); and CD1C (CD1c molecule). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See mhc1laa in Genome Data Viewer
Location:
chromosome: 8
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (44442258..44450240)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (44448309..44456628)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:ch73-211l2.1 Neighboring gene major histocompatibility complex class I-related gene protein-like Neighboring gene major histocompatibility complex class I LBA Neighboring gene major histocompatibility complex class II d8.46a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization of novel zebrafish MHC class I U lineage genes and their haplotype. Honjo Y, et al. Dev Comp Immunol, 2021 Mar. PMID 33279476
  2. Characterization of the Z lineage Major histocompatability complex class I genes in zebrafish. Dirscherl H, et al. Immunogenetics, 2014 Mar. PMID 24287892, Free PMC Article
  3. Multiple divergent haplotypes express completely distinct sets of class I MHC genes in zebrafish. McConnell SC, et al. Immunogenetics, 2014 Mar. PMID 24291825, Free PMC Article
  4. A nonclassical MHC class I U lineage locus in zebrafish with a null haplotypic variant. Dirscherl H, et al. Immunogenetics, 2015 Sep. PMID 26254596, Free PMC Article
  5. The MHC class I genes of zebrafish. Dirscherl H, et al. Dev Comp Immunol, 2014 Sep. PMID 24631581, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
major histocompatibility complex class I LAA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017904.2 → NP_001017904.2  major histocompatibility complex class I LAA

    Status: VALIDATED

    Source sequence(s)
    CU571323
    UniProtKB/TrEMBL
    Q566P2
    Related
    ENSDARP00000123111.1, ENSDART00000143807.2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    44442258..44450240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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