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NRDE2 NRDE-2, necessary for RNA interference, domain containing [ Homo sapiens (human) ]

Gene ID: 55051, updated on 24-Nov-2020

Summary

Official Symbol
NRDE2provided by HGNC
Official Full Name
NRDE-2, necessary for RNA interference, domain containingprovided by HGNC
Primary source
HGNC:HGNC:20186
See related
Ensembl:ENSG00000119720 MIM:618631
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf102
Expression
Ubiquitous expression in duodenum (RPKM 3.4), thyroid (RPKM 3.4) and 25 other tissues See more
Orthologs

Genomic context

See NRDE2 in Genome Data Viewer
Location:
14q32.11
Exon count:
16
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (90267860..90331969, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (90744398..90798481, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene tyrosyl-DNA phosphodiesterase 1 Neighboring gene potassium two pore domain channel subfamily K member 13 Neighboring gene glutaredoxin pseudogene 2 Neighboring gene proteasome 26S subunit, ATPase 1 Neighboring gene uncharacterized LOC105370618 Neighboring gene ribosomal protein L21 pseudogene 11 Neighboring gene Sharpr-MPRA regulatory region 5900 Neighboring gene calmodulin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Joint influence of small-effect genetic variants on human longevity.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10008, FLJ14051

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA interference IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heterochromatin assembly by small RNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of RNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of RNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear exosome regulator NRDE2
Names
UPF0614 protein C14orf102
protein NRDE2 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017970.4NP_060440.2  nuclear exosome regulator NRDE2

    See identical proteins and their annotated locations for NP_060440.2

    Status: VALIDATED

    Source sequence(s)
    AK294958, AL161662, AL355074, AW196499, BC008925
    Consensus CDS
    CCDS9890.1
    UniProtKB/Swiss-Prot
    Q9H7Z3
    Related
    ENSP00000346335.3, ENST00000354366.8
    Conserved Domains (1) summary
    pfam08424
    Location:313645
    NRDE-2; necessary for RNA interference

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    90267860..90331969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021394.2XP_016876883.1  nuclear exosome regulator NRDE2 isoform X2

    Conserved Domains (2) summary
    COG5107
    Location:10781167
    RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
    pfam08424
    Location:313655
    NRDE-2; necessary for RNA interference
  2. XM_017021396.1XP_016876885.1  nuclear exosome regulator NRDE2 isoform X4

    Conserved Domains (1) summary
    pfam08424
    Location:1150
    NRDE-2; necessary for RNA interference
  3. XM_017021395.1XP_016876884.1  nuclear exosome regulator NRDE2 isoform X3

    Conserved Domains (1) summary
    pfam08424
    Location:82414
    NRDE-2; necessary for RNA interference
  4. XM_011536886.2XP_011535188.1  nuclear exosome regulator NRDE2 isoform X1

    Conserved Domains (1) summary
    pfam08424
    Location:313655
    NRDE-2; necessary for RNA interference

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199043.1: Suppressed sequence

    Description
    NM_199043.1: This RefSeq was permanently suppressed because the use of the supported start codon for this gene renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
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