frg1 FSHD region gene 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: frg1provided by ZNC
Official Full Name: FSHD region gene 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-324
See related: Ensembl:ENSDARG00000056504 AllianceGenome:ZFIN:ZDB-GENE-050417-324
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:112426
Summary: Predicted to enable actin filament binding activity. Predicted to be located in nucleus. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in nucleolus and striated muscle dense body. Orthologous to human FRG1 (FSHD region gene 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	1	NC_133176.1 (18216519..18230421, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (16675055..16688965, complement)

Chromosome 1 - NC_133176.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Cajal body	IEA Inferred from Electronic Annotation more info
located_in Z disc	IEA Inferred from Electronic Annotation more info
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in striated muscle dense body	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein FRG1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.