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REX1BD required for excision 1-B domain containing [ Homo sapiens (human) ]

Gene ID: 55049, updated on 24-Nov-2020

Summary

Official Symbol
REX1BDprovided by HGNC
Official Full Name
required for excision 1-B domain containingprovided by HGNC
Primary source
HGNC:HGNC:26098
See related
Ensembl:ENSG00000006015
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C19orf60
Expression
Ubiquitous expression in fat (RPKM 15.5), spleen (RPKM 13.5) and 23 other tissues See more
Orthologs

Genomic context

See REX1BD in Genome Data Viewer
Location:
19p13.11
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (18588798..18592337)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18699495..18703147)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11651 Neighboring gene FKBP prolyl isomerase 8 Neighboring gene KxDL motif containing 1 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 Neighboring gene Sharpr-MPRA regulatory region 11645 Neighboring gene cytokine receptor like factor 1 Neighboring gene transmembrane protein 59 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20850, FLJ30108, FLJ34606, FLJ37391

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
required for excision 1-B domain-containing protein
Names
uncharacterized protein C19orf60

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100418.2NP_001093888.1  required for excision 1-B domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_001093888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    BC012078
    Consensus CDS
    CCDS42524.1
    UniProtKB/Swiss-Prot
    Q96EN9
    Related
    ENSP00000351422.5, ENST00000358607.10
    Conserved Domains (1) summary
    pfam14966
    Location:40157
    DNA_repr_REX1B; DNA repair REX1-B
  2. NM_001100419.2NP_001093889.1  required for excision 1-B domain-containing protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    BC012078, BI836487, DB254892
    Consensus CDS
    CCDS46019.1
    UniProtKB/Swiss-Prot
    Q96EN9
    Related
    ENSP00000398467.1, ENST00000450195.6
    Conserved Domains (1) summary
    pfam14966
    Location:40135
    DNA_repr_REX1B; DNA repair REX1-B

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    18588798..18592337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451571.1XP_024307339.1  required for excision 1-B domain-containing protein isoform X1

    Related
    ENST00000597371.1
    Conserved Domains (1) summary
    pfam14966
    Location:94169
    DNA_repr_REX1B; DNA repair REX1-B

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_017967.2: Suppressed sequence

    Description
    NM_017967.2: This RefSeq was permanently suppressed because it contains the wrong CDS, and the correct CDS would make it a nonsense-mediated mRNA decay (NMD) candidate.
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