hspb2 heat shock protein, alpha-crystallin-related, b2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hspb2provided by ZNC
Official Full Name: heat shock protein, alpha-crystallin-related, b2provided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-260
See related: Ensembl:ENSDARG00000052450 AllianceGenome:ZFIN:ZDB-GENE-050417-260
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:112532
Summary: Predicted to enable unfolded protein binding activity. Predicted to be involved in negative regulation of apoptotic process; protein refolding; and response to heat. Predicted to be active in cytoplasm and nucleus. Is expressed in heart. Orthologous to human HSPB2 (heat shock protein family B (small) member 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	5	NC_133180.1 (62889981..62902753, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (57629131..57635664, complement)

Chromosome 5 - NC_133180.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hspb2 is expressed during development.
Title: Genome-wide analysis and expression profiling of the small heat shock proteins in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables structural constituent of eye lens	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heat shock protein beta-2

Names: heat shock 27kDa protein 2; small heat shock protein HSPB2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017744.1 → NP_001017744.1 heat shock protein beta-2

See identical proteins and their annotated locations for NP_001017744.1

Status: PROVISIONAL

Source sequence(s)

BC093369

UniProtKB/TrEMBL

A0A2R8QSH6, F8W495, Q566R8

Related

ENSDARP00000068795.4, ENSDART00000074306.6

Conserved Domains (2) summary

cd06476
Location:63 → 145

ACD_HspB2_like; Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB2/heat shock 27kDa protein 2 and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally ...

COG0071
Location:64 → 162

IbpA; Molecular chaperone IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones]