gad2 glutamate decarboxylase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gad2provided by ZNC
Official Full Name: glutamate decarboxylase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030909-9
See related: Ensembl:ENSDARG00000015537 AllianceGenome:ZFIN:ZDB-GENE-030909-9
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: GAD65; zgc:112198
Summary: Predicted to enable glutamate decarboxylase activity. Acts upstream of or within gamma-aminobutyric acid biosynthetic process. Predicted to be located in several cellular components, including Golgi membrane; cytosol; and presynaptic membrane. Predicted to be active in cytoplasm. Is expressed in central nervous system; eye; and neurons. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; amphetamine abuse; diabetes mellitus (multiple); drug psychosis; and heroin dependence. Orthologous to human GAD2 (glutamate decarboxylase 2). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	24	NC_133199.1 (6325099..6350888, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (6133145..6158933, complement)

Chromosome 24 - NC_133199.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GAD65 mRNA was found in the periaqueductal gray.
Title: Molecular characterization and comparative localization of the mRNAs encoding two glutamic acid decarboxylases (GAD65 and GAD67) in the brain of the African lungfish, Protopterus annectens.

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General gene information

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Markers

fj38f12.x1 (e-PCR)
- UniSTS:199266

fc25b11.y1 (e-PCR)
- UniSTS:193242

fj04f02.x1 (e-PCR)
- UniSTS:198364

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carbon-carbon lyase activity	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables glutamate decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyrate shunt	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within gamma-aminobutyric acid biosynthetic process	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutamate decarboxylase 2

NP_001017708.2

EC 4.1.1.15

XP_068073170.1

EC 4.1.1.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017708.2 → NP_001017708.2 glutamate decarboxylase 2

Status: PROVISIONAL

Source sequence(s)

JBMGRA010000024

UniProtKB/TrEMBL

A0A8M1N545, F1R9E8

Related

ENSDARP00000010443.8, ENSDART00000021609.10

Conserved Domains (2) summary

pfam00282
Location:136 → 506

Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

cl21457
Location:511 → 561

TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...