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PPP1R2 protein phosphatase 1 regulatory inhibitor subunit 2 [ Homo sapiens (human) ]

Gene ID: 5504, updated on 11-Sep-2019

Summary

Official Symbol
PPP1R2provided by HGNC
Official Full Name
protein phosphatase 1 regulatory inhibitor subunit 2provided by HGNC
Primary source
HGNC:HGNC:9288
See related
Ensembl:ENSG00000184203 MIM:601792
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IPP2; IPP-2; PPP1R2A
Summary
Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Expression
Ubiquitous expression in bone marrow (RPKM 27.3), testis (RPKM 22.2) and 25 other tissues See more
Orthologs

Genomic context

See PPP1R2 in Genome Data Viewer
Location:
3q29
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (195514428..195543348, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (195241221..195270224, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene xyloside xylosyltransferase 1 Neighboring gene RNA, U6 small nuclear 25, pseudogene Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 Neighboring gene ribosomal protein L31 pseudogene 22 Neighboring gene RNA, U6atac small nuclear 24, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 73, pseudogene Neighboring gene ribosomal protein L24 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC87148

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine phosphatase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
generation of precursor metabolites and energy TAS
Traceable Author Statement
more info
PubMed 
glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein phosphatase inhibitor 2
Names
phosphoprotein phosphatase
NP_001278433.1
NP_001278434.1
NP_001303254.1
NP_006232.1
XP_006713745.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291504.2NP_001278433.1  protein phosphatase inhibitor 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC069213
    Conserved Domains (1) summary
    pfam04979
    Location:45164
    IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
  2. NM_001291505.2NP_001278434.1  protein phosphatase inhibitor 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC069213
    Related
    ENSP00000400238.1, ENST00000438848.5
    Conserved Domains (1) summary
    pfam04979
    Location:45137
    IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
  3. NM_001316325.2NP_001303254.1  protein phosphatase inhibitor 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC069213, BC007655, BI560631
    UniProtKB/Swiss-Prot
    P41236
    Conserved Domains (1) summary
    pfam04979
    Location:52143
    IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
  4. NM_006241.8NP_006232.1  protein phosphatase inhibitor 2 isoform 2

    See identical proteins and their annotated locations for NP_006232.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA259068, AC069213, BC007655
    Consensus CDS
    CCDS3309.1
    UniProtKB/Swiss-Prot
    P41236
    Related
    ENSP00000484580.1, ENST00000618156.5
    Conserved Domains (1) summary
    pfam04979
    Location:45164
    IPP-2; Protein phosphatase inhibitor 2 (IPP-2)

RNA

  1. NR_133014.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC069213, BC007655, BI549862

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    195514428..195543348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713682.3XP_006713745.1  protein phosphatase inhibitor 2 isoform X1

    Conserved Domains (1) summary
    pfam04979
    Location:45139
    IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
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