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srd5a2b steroid-5-alpha-reductase, alpha polypeptide 2b [ Danio rerio (zebrafish) ]

Gene ID: 550388, updated on 4-Jan-2025

Summary

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Official Symbol
srd5a2bprovided by ZNC
Official Full Name
steroid-5-alpha-reductase, alpha polypeptide 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-182
See related
Ensembl:ENSDARG00000039067 AllianceGenome:ZFIN:ZDB-GENE-050417-182
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:112455
Summary
Predicted to enable 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity. Predicted to be involved in androgen biosynthetic process. Predicted to act upstream of or within cell differentiation; sex differentiation; and steroid metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Is expressed in hindbrain; pectoral fin; and testis. Human ortholog(s) of this gene implicated in hypospadias and prostate cancer. Orthologous to human SRD5A2 (steroid 5 alpha-reductase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See srd5a2b in Genome Data Viewer
Location:
chromosome: 13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (35483260..35497646, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (35358230..35371829, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene SLX4 interacting protein Neighboring gene uncharacterized LOC137487424 Neighboring gene MKKS centrosomal shuttling protein Neighboring gene mediator of cell motility 1 Neighboring gene WD repeat domain 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Development of a Liquid Chromatography/Mass Spectrometry-Based Inhibition Assay for the Screening of Steroid 5-α Reductase in Human and Fish Cell Lines. Kim D, et al. Molecules, 2021 Feb 8. PMID 33567691, Free PMC Article
  2. The reproductive toxicity and potential mechanisms of combined exposure to dibutyl phthalate and diisobutyl phthalate in male zebrafish (Danio rerio). Chen H, et al. Chemosphere, 2020 Nov. PMID 32563064
  3. An miR-200 Cluster on Chromosome 23 Regulates Sperm Motility in Zebrafish. Xiong S, et al. Endocrinology, 2018 May 1. PMID 29579206
  4. Embryonic Atrazine Exposure Elicits Alterations in Genes Associated with Neuroendocrine Function in Adult Male Zebrafish. Wirbisky SE, et al. Toxicol Sci, 2016 Sep. PMID 27413107, Free PMC Article
  5. Behind melanocortin antagonist overexpression in the zebrafish brain: A behavioral and transcriptomic approach. Guillot R, et al. Horm Behav, 2016 Jun. PMID 27156808

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in androgen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sex differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
3-oxo-5-alpha-steroid 4-dehydrogenase 2b
NP_001017693.2
NP_001417996.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017693.2 → NP_001017693.2  3-oxo-5-alpha-steroid 4-dehydrogenase 2b isoform 2

    Status: VALIDATED

    Source sequence(s)
    CU681845
    UniProtKB/TrEMBL
    Q566V2
    Related
    ENSDARP00000124451.1, ENSDART00000148402.2

  2. NM_001431067.1 → NP_001417996.1  3-oxo-5-alpha-steroid 4-dehydrogenase 2b isoform 1

    Status: VALIDATED

    Source sequence(s)
    CU681845
    UniProtKB/TrEMBL
    A0A8M2B3D1, Q566V2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    35483260..35497646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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