Format

Send to:

Choose Destination

NOL8 nucleolar protein 8 [ Homo sapiens (human) ]

Gene ID: 55035, updated on 4-Jul-2021

Summary

Official Symbol
NOL8provided by HGNC
Official Full Name
nucleolar protein 8provided by HGNC
Primary source
HGNC:HGNC:23387
See related
Ensembl:ENSG00000198000 MIM:611534
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOP132; C9orf34; bA62C3.3; bA62C3.4
Summary
NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in lymph node (RPKM 8.0), appendix (RPKM 6.7) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See NOL8 in Genome Data Viewer
Location:
9q22.31
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (92297358..92325994, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (95059640..95087632, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268048 Neighboring gene isoleucyl-tRNA synthetase 1 Neighboring gene microRNA 3651 Neighboring gene small nucleolar RNA, H/ACA box 84 Neighboring gene phagosome assembly factor 1 pseudogene Neighboring gene centromere protein P Neighboring gene osteoglycin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20736, DKFZp686P12242

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein localization to nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to nucleolus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nucleolar protein 8
Names
nucleolar protein Nop132

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256394.2NP_001243323.1  nucleolar protein 8 isoform b

    See identical proteins and their annotated locations for NP_001243323.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AB105104, BC146810
    Consensus CDS
    CCDS59135.1
    UniProtKB/Swiss-Prot
    Q76FK4
    UniProtKB/TrEMBL
    A6H8Z4
    Related
    ENSP00000351723.4, ENST00000358855.8
    Conserved Domains (1) summary
    cl17169
    Location:120
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_001330722.2NP_001317651.1  nucleolar protein 8 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate, in-frame exon in the central coding region compared to variant 1. It encodes isoform c, which is shorter than isoform a.
    Source sequence(s)
    AB105104, AL136097, BM475696, DB227423, DB516208
    Consensus CDS
    CCDS83384.1
    UniProtKB/Swiss-Prot
    Q76FK4
    Related
    ENSP00000441300.1, ENST00000535387.5
    Conserved Domains (1) summary
    cd12226
    Location:988
    RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins
  3. NM_017948.6NP_060418.4  nucleolar protein 8 isoform a

    See identical proteins and their annotated locations for NP_060418.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AB105104, AL136097
    Consensus CDS
    CCDS47993.1
    UniProtKB/Swiss-Prot
    Q76FK4
    Related
    ENSP00000401177.2, ENST00000442668.7
    Conserved Domains (1) summary
    cd12226
    Location:988
    RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins

RNA

  1. NR_046106.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB105104, AL136097, BC146810
    Related
    ENST00000544867.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    92297358..92325994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518824.3XP_011517126.1  nucleolar protein 8 isoform X3

    See identical proteins and their annotated locations for XP_011517126.1

    UniProtKB/Swiss-Prot
    Q76FK4
    Related
    ENSP00000440709.1, ENST00000542053.5
    Conserved Domains (1) summary
    cl17169
    Location:120
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. XM_024447594.1XP_024303362.1  nucleolar protein 8 isoform X3

    Conserved Domains (1) summary
    cl17169
    Location:120
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_017014880.2XP_016870369.1  nucleolar protein 8 isoform X6

  4. XM_006717172.4XP_006717235.1  nucleolar protein 8 isoform X5

    See identical proteins and their annotated locations for XP_006717235.1

  5. XM_024447595.1XP_024303363.1  nucleolar protein 8 isoform X5

  6. XM_017014877.2XP_016870366.1  nucleolar protein 8 isoform X4

  7. XM_006717170.4XP_006717233.1  nucleolar protein 8 isoform X3

    See identical proteins and their annotated locations for XP_006717233.1

    UniProtKB/Swiss-Prot
    Q76FK4
    Conserved Domains (1) summary
    cl17169
    Location:120
    RRM_SF; RNA recognition motif (RRM) superfamily
  8. XM_006717173.4XP_006717236.1  nucleolar protein 8 isoform X5

    See identical proteins and their annotated locations for XP_006717236.1

  9. XM_017014876.2XP_016870365.1  nucleolar protein 8 isoform X2

    UniProtKB/Swiss-Prot
    Q76FK4
    Conserved Domains (1) summary
    cd12226
    Location:988
    RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins
  10. XM_006717166.4XP_006717229.1  nucleolar protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006717229.1

    UniProtKB/Swiss-Prot
    Q76FK4
    Conserved Domains (1) summary
    cd12226
    Location:988
    RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins
  11. XM_017014878.2XP_016870367.1  nucleolar protein 8 isoform X5

  12. XM_006717169.4XP_006717232.1  nucleolar protein 8 isoform X3

    See identical proteins and their annotated locations for XP_006717232.1

    UniProtKB/Swiss-Prot
    Q76FK4
    Conserved Domains (1) summary
    cl17169
    Location:120
    RRM_SF; RNA recognition motif (RRM) superfamily
  13. XM_006717167.3XP_006717230.1  nucleolar protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006717230.1

    UniProtKB/Swiss-Prot
    Q76FK4
    Conserved Domains (1) summary
    cd12226
    Location:988
    RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins
  14. XM_017014879.1XP_016870368.1  nucleolar protein 8 isoform X5

  15. XM_011518827.2XP_011517129.1  nucleolar protein 8 isoform X5

    See identical proteins and their annotated locations for XP_011517129.1

RNA

  1. XR_001746333.2 RNA Sequence

  2. XR_001746334.2 RNA Sequence

    Related
    ENST00000536593.5
Support Center