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NOL8 nucleolar protein 8 [ Homo sapiens (human) ]

Gene ID: 55035, updated on 3-Mar-2026
Official Symbol
NOL8provided by HGNC
Official Full Name
nucleolar protein 8provided by HGNC
Primary source
HGNC:HGNC:23387
See related
Ensembl:ENSG00000198000 MIM:611534; AllianceGenome:HGNC:23387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOP132; C9orf34; bA62C3.3; bA62C3.4
Summary
NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in lymph node (RPKM 8.0), appendix (RPKM 6.7) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See NOL8 in Genome Data Viewer
Location:
9q22.31
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (92297358..92325350, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (104463887..104491879, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (95059640..95087632, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268048 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:94976657-94977553 Neighboring gene isoleucyl-tRNA synthetase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95012769-95013269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28593 Neighboring gene microRNA 3651 Neighboring gene small nucleolar RNA, H/ACA box 84 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:95086914-95087802 Neighboring gene phagophore assembly factor 1 pseudogene Neighboring gene centromere protein P Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_109628 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_109638 Neighboring gene osteoglycin

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. NOL8, the binding protein for beta-catenin, promoted the growth and migration of prostate cancer cells. Gu S, et al. Chem Biol Interact, 2018 Oct 1. PMID 30125550
  2. Identification of NOL8, a nucleolar protein containing an RNA recognition motif (RRM), which was overexpressed in diffuse-type gastric cancer. Jinawath N, et al. Cancer Sci, 2004 May. PMID 15132771, Free PMC Article
  3. A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. Sekiguchi T, et al. J Biol Chem, 2004 Feb 27. PMID 14660641
  4. NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. Sekiguchi T, et al. Nucleic Acids Res, 2006. PMID 16963496, Free PMC Article
  5. Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. Sekiguchi T, et al. J Biol Chem, 2001 Mar 9. PMID 11073942

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  2. nucleolar protein 132(Nop132) is associated with the GTP form, but not the GDP form, of ras-related GTP binding protein RRAG A, suggesting that RRAG A might regulate Nop132 function
    Title: A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ20736, DKFZp686P12242

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein localization to nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to nucleolus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
nucleolar protein 8
Names
nucleolar protein Nop132

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256394.2 → NP_001243323.1  nucleolar protein 8 isoform b

    See identical proteins and their annotated locations for NP_001243323.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AB105104, BC146810
    Consensus CDS
    CCDS59135.1
    UniProtKB/TrEMBL
    A6H8Z4
    Related
    ENSP00000351723.4, ENST00000358855.8
    Conserved Domains (1) summary
    cl17169
    Location:1 → 20
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001330722.2 → NP_001317651.1  nucleolar protein 8 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate, in-frame exon in the central coding region compared to variant 1. It encodes isoform c, which is shorter than isoform a.
    Source sequence(s)
    AB105104, AL136097, BM475696, DB227423, DB516208
    Consensus CDS
    CCDS83384.1
    UniProtKB/TrEMBL
    A6H8Z4
    Related
    ENSP00000441300.1, ENST00000535387.5
    Conserved Domains (1) summary
    cd12226
    Location:9 → 88
    RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins

  3. NM_001438004.1 → NP_001424933.1  nucleolar protein 8 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL136097
    UniProtKB/TrEMBL
    A6H8Z4
    Related
    ENSP00000440709.1, ENST00000542053.5

  4. NM_001438180.1 → NP_001425109.1  nucleolar protein 8 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL136097
    UniProtKB/Swiss-Prot
    Q5TCC7, Q5TCC8, Q5TCD3, Q5TCD5, Q5TCD6, Q5TCD7, Q76D35, Q76FK4, Q7L3E2, Q9H586, Q9H795, Q9H7W7, Q9H9J6, Q9NWA4, Q9NWM4
    UniProtKB/TrEMBL
    A6H8Z4
    Related
    ENSP00000441140.1, ENST00000545558.5

  5. NM_001438181.1 → NP_001425110.1  nucleolar protein 8 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL136097
    UniProtKB/Swiss-Prot
    Q5TCC7, Q5TCC8, Q5TCD3, Q5TCD5, Q5TCD6, Q5TCD7, Q76D35, Q76FK4, Q7L3E2, Q9H586, Q9H795, Q9H7W7, Q9H9J6, Q9NWA4, Q9NWM4
    UniProtKB/TrEMBL
    A6H8Z4

  6. NM_017948.6 → NP_060418.4  nucleolar protein 8 isoform a

    See identical proteins and their annotated locations for NP_060418.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AB105104, AL136097
    Consensus CDS
    CCDS47993.1
    UniProtKB/Swiss-Prot
    Q5TCC7, Q5TCC8, Q5TCD3, Q5TCD5, Q5TCD6, Q5TCD7, Q76D35, Q76FK4, Q7L3E2, Q9H586, Q9H795, Q9H7W7, Q9H9J6, Q9NWA4, Q9NWM4
    UniProtKB/TrEMBL
    A6H8Z4
    Related
    ENSP00000401177.2, ENST00000442668.7
    Conserved Domains (1) summary
    cd12226
    Location:9 → 88
    RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins

RNA

  1. NR_046106.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB105104, AL136097, BC146810
    Related
    ENST00000544867.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    92297358..92325350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447594.2 → XP_024303362.1  nucleolar protein 8 isoform X2

    UniProtKB/TrEMBL
    A6H8Z4
    Conserved Domains (1) summary
    cl17169
    Location:1 → 20
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_011518827.3 → XP_011517129.1  nucleolar protein 8 isoform X4

    See identical proteins and their annotated locations for XP_011517129.1

    UniProtKB/TrEMBL
    A6H8Z4

  3. XM_047423554.1 → XP_047279510.1  nucleolar protein 8 isoform X3

    UniProtKB/TrEMBL
    F5H101

  4. XM_047423555.1 → XP_047279511.1  nucleolar protein 8 isoform X5

    UniProtKB/TrEMBL
    F8WE42
    Related
    ENSP00000414112.2, ENST00000432670.6

  5. XM_047423556.1 → XP_047279512.1  nucleolar protein 8 isoform X6

    UniProtKB/TrEMBL
    F8WE42

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791788.1 Reference GRCh38.p14 PATCHES

    Range
    132087..160079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333097.1 → XP_054189072.1  nucleolar protein 8 isoform X2

    UniProtKB/TrEMBL
    A6H8Z4

  2. XM_054333099.1 → XP_054189074.1  nucleolar protein 8 isoform X4

    UniProtKB/TrEMBL
    A6H8Z4

  3. XM_054333098.1 → XP_054189073.1  nucleolar protein 8 isoform X3

    UniProtKB/TrEMBL
    F5H101

  4. XM_054333100.1 → XP_054189075.1  nucleolar protein 8 isoform X5

    UniProtKB/TrEMBL
    F8WE42

  5. XM_054333101.1 → XP_054189076.1  nucleolar protein 8 isoform X6

    UniProtKB/TrEMBL
    F8WE42

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    104463887..104491879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363207.1 → XP_054219182.1  nucleolar protein 8 isoform X2

    UniProtKB/TrEMBL
    A6H8Z4

  2. XM_054363209.1 → XP_054219184.1  nucleolar protein 8 isoform X4

    UniProtKB/TrEMBL
    A6H8Z4

  3. XM_054363208.1 → XP_054219183.1  nucleolar protein 8 isoform X3

    UniProtKB/TrEMBL
    F5H101

  4. XM_054363210.1 → XP_054219185.1  nucleolar protein 8 isoform X5

    UniProtKB/TrEMBL
    F8WE42

  5. XM_054363211.1 → XP_054219186.1  nucleolar protein 8 isoform X6

    UniProtKB/TrEMBL
    F8WE42
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q76FK4.1 GenPept UniProtKB/Swiss-Prot:Q76FK4

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