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SLC35A5 solute carrier family 35 member A5 [ Homo sapiens (human) ]

Gene ID: 55032, updated on 21-Dec-2019

Summary

Official Symbol
SLC35A5provided by HGNC
Official Full Name
solute carrier family 35 member A5provided by HGNC
Primary source
HGNC:HGNC:20792
See related
Ensembl:ENSG00000138459
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a transmembrane protein which belongs to subfamily 35A of the solute carrier superfamily. The encoded protein is a nucleoside-sugar transporter. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Expression
Ubiquitous expression in thyroid (RPKM 18.1), brain (RPKM 17.1) and 25 other tissues See more
Orthologs

Genomic context

See SLC35A5 in Genome Data Viewer
Location:
3q13.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (112561320..112585579)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (112280857..112303286)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene B and T lymphocyte associated Neighboring gene olfactory receptor family 7 subfamily E member 100 pseudogene Neighboring gene autophagy related 3 Neighboring gene coiled-coil domain containing 80 Neighboring gene methionine adenosyltransferase 2A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11130, FLJ20730, FLJ25973, DKFZp434E102

Gene Ontology Provided by GOA

Function Evidence Code Pubs
pyrimidine nucleotide-sugar transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
carbohydrate transport IEA
Inferred from Electronic Annotation
more info
 
pyrimidine nucleotide-sugar transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable UDP-sugar transporter protein SLC35A5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052994.1 RefSeqGene

    Range
    5666..29258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001348905.1NP_001335834.1  probable UDP-sugar transporter protein SLC35A5 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (1).
    Source sequence(s)
    AB075484, AC048334, AC092692, BC010307
    Consensus CDS
    CCDS2967.1
    Conserved Domains (1) summary
    pfam04142
    Location:24374
    Nuc_sug_transp; Nucleotide-sugar transporter
  2. NM_001348906.1NP_001335835.1  probable UDP-sugar transporter protein SLC35A5 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (1).
    Source sequence(s)
    AB075484, AC048334, AC092692, BC010307
    Consensus CDS
    CCDS2967.1
    Conserved Domains (1) summary
    pfam04142
    Location:24374
    Nuc_sug_transp; Nucleotide-sugar transporter
  3. NM_001348907.2NP_001335836.1  probable UDP-sugar transporter protein SLC35A5 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (1).
    Source sequence(s)
    AC048334, AC092692
    Consensus CDS
    CCDS2967.1
    Conserved Domains (1) summary
    pfam04142
    Location:24374
    Nuc_sug_transp; Nucleotide-sugar transporter
  4. NM_001348908.2NP_001335837.1  probable UDP-sugar transporter protein SLC35A5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate exons in the 5' coding region compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC048334, AC092692
    Conserved Domains (1) summary
    pfam04142
    Location:13256
    Nuc_sug_transp; Nucleotide-sugar transporter
  5. NM_001348909.2NP_001335838.1  probable UDP-sugar transporter protein SLC35A5 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (3) has shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC048334, AC092692
    Conserved Domains (1) summary
    pfam04142
    Location:10253
    Nuc_sug_transp; Nucleotide-sugar transporter
  6. NM_001348910.2NP_001335839.1  probable UDP-sugar transporter protein SLC35A5 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an alternate exon structure in the 3' coding region region leading to a frameshift and differs in the 3' UTR, compared to variant 1. The encoded isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC048334, AC092692
    Consensus CDS
    CCDS87121.1
    Related
    ENSP00000261034.2, ENST00000261034.6
    Conserved Domains (1) summary
    pfam04142
    Location:24162
    Nuc_sug_transp; Nucleotide-sugar transporter
  7. NM_001348911.2NP_001335840.1  probable UDP-sugar transporter protein SLC35A5 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site in the 3' coding region region leading to a frameshift and differs in the 3' UTR compared to variant 1. The encoded isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC048334, AC092692
    Conserved Domains (1) summary
    pfam04142
    Location:24162
    Nuc_sug_transp; Nucleotide-sugar transporter
  8. NM_017945.5NP_060415.1  probable UDP-sugar transporter protein SLC35A5 isoform 1

    See identical proteins and their annotated locations for NP_060415.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1-4 encode the same isoform (1).
    Source sequence(s)
    AC048334, AC092692
    Consensus CDS
    CCDS2967.1
    UniProtKB/Swiss-Prot
    Q9BS91
    Related
    ENSP00000417654.1, ENST00000492406.6
    Conserved Domains (1) summary
    pfam04142
    Location:24374
    Nuc_sug_transp; Nucleotide-sugar transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    112561320..112585579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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