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USP47 ubiquitin specific peptidase 47 [ Homo sapiens (human) ]

Gene ID: 55031, updated on 9-Feb-2020

Summary

Official Symbol
USP47provided by HGNC
Official Full Name
ubiquitin specific peptidase 47provided by HGNC
Primary source
HGNC:HGNC:20076
See related
Ensembl:ENSG00000170242 MIM:614460
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRFP
Expression
Ubiquitous expression in brain (RPKM 11.7), heart (RPKM 10.2) and 25 other tissues See more
Orthologs

Genomic context

See USP47 in Genome Data Viewer
Location:
11p15.3
Exon count:
31
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (11841972..11961887)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (11862970..11980872)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene microRNA 4299 Neighboring gene microRNA 8070 Neighboring gene uncharacterized LOC107984311 Neighboring gene H3 histone pseudogene 33 Neighboring gene dickkopf WNT signaling pathway inhibitor 3 Neighboring gene long intergenic non-protein coding RNA 2547

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20727, DKFZp686C13257

Gene Ontology Provided by GOA

Function Evidence Code Pubs
WD40-repeat domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
thiol-dependent ubiquitinyl hydrolase activity TAS
Traceable Author Statement
more info
 
ubiquitinyl hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 47
Names
Trf (TATA binding protein-related factor)-proximal homolog
deubiquitinating enzyme 47
ubiquitin thioesterase 47
ubiquitin thiolesterase 47
ubiquitin-specific-processing protease 47
NP_001269588.1
NP_001317137.1
NP_001359020.1
NP_001359021.1
NP_001359022.1
NP_001359023.1
NP_001359024.1
NP_001359025.1
NP_001359026.1
NP_001359027.1
NP_001359028.1
NP_001359029.1
NP_001359030.1
NP_001359031.1
NP_001359032.1
NP_060414.3
XP_011518498.1
XP_016873443.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282659.2NP_001269588.1  ubiquitin carboxyl-terminal hydrolase 47 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC104383, AC124276
    Consensus CDS
    CCDS60725.1
    UniProtKB/Swiss-Prot
    Q96K76
    UniProtKB/TrEMBL
    Q68D97
    Related
    ENSP00000433146.1, ENST00000527733.6
    Conserved Domains (2) summary
    cd02659
    Location:166546
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:167541
    UCH; Ubiquitin carboxyl-terminal hydrolase
  2. NM_001330208.2NP_001317137.1  ubiquitin carboxyl-terminal hydrolase 47 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC104383, AC124276
    Consensus CDS
    CCDS81554.1
    UniProtKB/Swiss-Prot
    Q96K76
    Related
    ENSP00000382382.2, ENST00000399455.2
  3. NM_001372091.1NP_001359020.1  ubiquitin carboxyl-terminal hydrolase 47 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC104383, AC124276
  4. NM_001372092.1NP_001359021.1  ubiquitin carboxyl-terminal hydrolase 47 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC104383, AC124276
  5. NM_001372093.1NP_001359022.1  ubiquitin carboxyl-terminal hydrolase 47 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC104383, AC124276
  6. NM_001372094.1NP_001359023.1  ubiquitin carboxyl-terminal hydrolase 47 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC104383, AC124276
  7. NM_001372095.1NP_001359024.1  ubiquitin carboxyl-terminal hydrolase 47 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC104383, AC124276
  8. NM_001372096.1NP_001359025.1  ubiquitin carboxyl-terminal hydrolase 47 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC104383, AC124276
  9. NM_001372097.1NP_001359026.1  ubiquitin carboxyl-terminal hydrolase 47 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC104383, AC124276
  10. NM_001372098.1NP_001359027.1  ubiquitin carboxyl-terminal hydrolase 47 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC104383, AC124276
  11. NM_001372099.1NP_001359028.1  ubiquitin carboxyl-terminal hydrolase 47 isoform k

    Status: VALIDATED

    Source sequence(s)
    AC104383, AC124276
  12. NM_001372100.1NP_001359029.1  ubiquitin carboxyl-terminal hydrolase 47 isoform l

    Status: VALIDATED

    Source sequence(s)
    AC104383, AC124276
  13. NM_001372101.1NP_001359030.1  ubiquitin carboxyl-terminal hydrolase 47 isoform n

    Status: VALIDATED

    Source sequence(s)
    AC104383, AC124276
  14. NM_001372102.1NP_001359031.1  ubiquitin carboxyl-terminal hydrolase 47 isoform o

    Status: VALIDATED

    Source sequence(s)
    AC104383, AC124276
  15. NM_001372103.1NP_001359032.1  ubiquitin carboxyl-terminal hydrolase 47 isoform m

    Status: VALIDATED

    Source sequence(s)
    AC104383, AC124276
  16. NM_017944.4NP_060414.3  ubiquitin carboxyl-terminal hydrolase 47 isoform b

    See identical proteins and their annotated locations for NP_060414.3

    Status: VALIDATED

    Source sequence(s)
    AC104383, AC124276
    Consensus CDS
    CCDS41619.1
    UniProtKB/Swiss-Prot
    Q96K76
    Related
    ENSP00000339957.5, ENST00000339865.9
    Conserved Domains (2) summary
    cd02659
    Location:98478
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:99473
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    11841972..11961887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017954.1XP_016873443.1  ubiquitin carboxyl-terminal hydrolase 47 isoform X2

    Conserved Domains (1) summary
    cl02553
    Location:1167
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  2. XM_011520196.1XP_011518498.1  ubiquitin carboxyl-terminal hydrolase 47 isoform X2

    Conserved Domains (1) summary
    cl02553
    Location:1167
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
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