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FBXO34 F-box protein 34 [ Homo sapiens (human) ]

Gene ID: 55030, updated on 7-Oct-2018

Summary

Official Symbol
FBXO34provided by HGNC
Official Full Name
F-box protein 34provided by HGNC
Primary source
HGNC:HGNC:20201
See related
Ensembl:ENSG00000178974 MIM:609104; Vega:OTTHUMG00000171033
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fbx34; CGI-301
Summary
Members of the F-box protein family, such as FBXO34, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 12.2), esophagus (RPKM 11.1) and 25 other tissues See more
Orthologs

Genomic context

See FBXO34 in Genome Data Viewer
Location:
14q22.3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (55271303..55353611)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (55738021..55820329)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 L1 (pseudogene) Neighboring gene cytochrome c oxidase subunit 5A pseudogene 1 Neighboring gene uncharacterized LOC105370509 Neighboring gene ribosomal protein L34 pseudogene 28 Neighboring gene charged multivesicular body protein 4B pseudogene 1 Neighboring gene autophagy related 14 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 1 Neighboring gene ribosomal protein L21 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20725, MGC126434, MGC126435, DKFZp547C162

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
F-box only protein 34
Names
protein CGI-301

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017943.3NP_060413.2  F-box only protein 34

    See identical proteins and their annotated locations for NP_060413.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the more frequently occurring and longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AI911690, BC109120, DA228125
    Consensus CDS
    CCDS32086.1
    UniProtKB/Swiss-Prot
    Q9NWN3
    UniProtKB/TrEMBL
    A0A024R653
    Related
    ENSP00000313159.4, OTTHUMP00000244931, ENST00000313833.4, OTTHUMT00000411322
    Conserved Domains (1) summary
    pfam12937
    Location:575609
    F-box-like; F-box-like
  2. NM_152231.1NP_689417.1  F-box only protein 34

    See identical proteins and their annotated locations for NP_689417.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL158801
    Consensus CDS
    CCDS32086.1
    UniProtKB/Swiss-Prot
    Q9NWN3
    UniProtKB/TrEMBL
    A0A024R653
    Related
    ENSP00000394117.1, ENST00000440021.1
    Conserved Domains (1) summary
    pfam12937
    Location:575609
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    55271303..55353611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720185.3XP_006720248.1  F-box only protein 34 isoform X2

    See identical proteins and their annotated locations for XP_006720248.1

    UniProtKB/Swiss-Prot
    Q9NWN3
    UniProtKB/TrEMBL
    A0A024R653
    Conserved Domains (1) summary
    pfam12937
    Location:575609
    F-box-like; F-box-like
  2. XM_017021391.1XP_016876880.1  F-box only protein 34 isoform X1

  3. XM_017021392.1XP_016876881.1  F-box only protein 34 isoform X2

    UniProtKB/Swiss-Prot
    Q9NWN3
    UniProtKB/TrEMBL
    A0A024R653
    Conserved Domains (1) summary
    pfam12937
    Location:575609
    F-box-like; F-box-like
  4. XM_017021393.2XP_016876882.1  F-box only protein 34 isoform X2

    UniProtKB/Swiss-Prot
    Q9NWN3
    UniProtKB/TrEMBL
    A0A024R653
    Conserved Domains (1) summary
    pfam12937
    Location:575609
    F-box-like; F-box-like
  5. XM_005267791.4XP_005267848.1  F-box only protein 34 isoform X2

    See identical proteins and their annotated locations for XP_005267848.1

    UniProtKB/Swiss-Prot
    Q9NWN3
    UniProtKB/TrEMBL
    A0A024R653
    Conserved Domains (1) summary
    pfam12937
    Location:575609
    F-box-like; F-box-like
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