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kif3a kinesin family member 3A [ Danio rerio (zebrafish) ]

Gene ID: 550267, updated on 9-Sep-2025
Official Symbol
kif3aprovided by ZNC
Official Full Name
kinesin family member 3Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-71
See related
Ensembl:ENSDARG00000087538 AllianceGenome:ZFIN:ZDB-GENE-050417-71
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc55h04; wu:fc55h04; zgc:110284
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; photoreceptor cell maintenance; and photoreceptor cell outer segment organization. Part of kinesin complex. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Orthologous to human KIF3A (kinesin family member 3A). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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Location:
chromosome: 14
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 14 NC_133189.1 (28241520..28270270)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 14 NC_007125.7 (23970818..23999566)

Chromosome 14 - NC_133189.1Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 16a Neighboring gene SH3 domain containing ring finger 2 Neighboring gene uncharacterized LOC137487587 Neighboring gene uncharacterized LOC137487521 Neighboring gene interleukin 4 Neighboring gene uncharacterized LOC137487520

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Unexpected Roles for Ciliary Kinesins and Intraflagellar Transport Proteins. Pooranachandran N, et al. Genetics, 2016 Jun. PMID 27038111, Free PMC Article
  2. Abnormal photoreceptor outer segment development and early retinal degeneration in kif3a mutant zebrafish. Raghupathy RK, et al. Cell Biochem Funct, 2016 Aug. PMID 27470972
  3. Rapid identification of kidney cyst mutations by whole exome sequencing in zebrafish. Ryan S, et al. Development, 2013 Nov. PMID 24130329, Free PMC Article
  4. Cilia regulate meiotic recombination in zebrafish. Xie H, et al. J Mol Cell Biol, 2022 Sep 27. PMID 35981808, Free PMC Article
  5. The intraflagellar transport protein IFT57 is required for cilia maintenance and regulates IFT-particle-kinesin-II dissociation in vertebrate photoreceptors. Krock BL, et al. J Cell Sci, 2008 Jun 1. PMID 18492793, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anterograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within_positive_effect cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cilium organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within photoreceptor cell maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within photoreceptor cell outer segment organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in system development IEA
Inferred from Electronic Annotation
more info
  
involved_in transport along microtubule IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin II complex IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of kinesin complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
kinesin-like protein KIF3A

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017604.2 → NP_001017604.2  kinesin-like protein KIF3A

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000014
    UniProtKB/TrEMBL
    A0A8M1N5C3, E9QB71
    Related
    ENSDARP00000107221.2, ENSDART00000123338.4
    Conserved Domains (2) summary
    cd01371
    Location:16 → 348
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    pfam00225
    Location:23 → 348
    Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133189.1 Reference GRCz12tu Primary Assembly

    Range
    28241520..28270270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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