Format

Send to:

Choose Destination

PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A [ Homo sapiens (human) ]

Gene ID: 5502, updated on 24-Nov-2020

Summary

Official Symbol
PPP1R1Aprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory inhibitor subunit 1Aprovided by HGNC
Primary source
HGNC:HGNC:9286
See related
Ensembl:ENSG00000135447 MIM:613246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
I1; IPP1
Expression
Biased expression in fat (RPKM 174.0), kidney (RPKM 33.7) and 3 other tissues See more
Orthologs

Genomic context

See PPP1R1A in Genome Data Viewer
Location:
12q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (54579246..54588659, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (54969176..54982451, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NCK associated protein 1 like Neighboring gene phosphodiesterase 1B Neighboring gene glycosylation dependent cell adhesion molecule 1 (pseudogene) Neighboring gene lacritin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 1A
Names
I-1
IPP-1
inhibitor-1
protein phosphatase inhibitor-1
NP_006732.3
XP_005269052.1
XP_006719534.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006741.4NP_006732.3  protein phosphatase 1 regulatory subunit 1A

    See identical proteins and their annotated locations for NP_006732.3

    Status: VALIDATED

    Source sequence(s)
    AC079310, BM876308, BP211831, U48707
    Consensus CDS
    CCDS44912.1
    UniProtKB/Swiss-Prot
    Q13522
    Related
    ENSP00000257905.8, ENST00000257905.13
    Conserved Domains (1) summary
    pfam05395
    Location:5142
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    54579246..54588659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719471.4XP_006719534.1  protein phosphatase 1 regulatory subunit 1A isoform X1

    Conserved Domains (1) summary
    pfam05395
    Location:583
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32
  2. XM_005268995.4XP_005269052.1  protein phosphatase 1 regulatory subunit 1A isoform X2

    Conserved Domains (1) summary
    pfam05395
    Location:583
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32
Support Center