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STX17 syntaxin 17 [ Homo sapiens (human) ]

Gene ID: 55014, updated on 3-Oct-2020

Summary

Official Symbol
STX17provided by HGNC
Official Full Name
syntaxin 17provided by HGNC
Primary source
HGNC:HGNC:11432
See related
Ensembl:ENSG00000136874 MIM:604204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 7.7), skin (RPKM 7.1) and 25 other tissues See more
Orthologs

Genomic context

See STX17 in Genome Data Viewer
Location:
9q31.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (99906654..99974541)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (102668915..102736818)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 4 group A member 3 Neighboring gene STX17 antisense RNA 1 Neighboring gene endoplasmic reticulum protein 44 Neighboring gene uncharacterized LOC105376176 Neighboring gene UPF3A pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20651, MGC102796, MGC126613, MGC126615

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNAP receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagosome maturation IDA
Inferred from Direct Assay
more info
PubMed 
autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagosome membrane docking IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to phagophore assembly site IDA
Inferred from Direct Assay
more info
PubMed 
vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
COPII-coated ER to Golgi transport vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
ER to Golgi transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with HOPS complex IDA
Inferred from Direct Assay
more info
PubMed 
Mitochondria-associated ER Membrane IDA
Inferred from Direct Assay
more info
PubMed 
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE complex IDA
Inferred from Direct Assay
more info
PubMed 
autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
NOT mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
smooth endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017919.3NP_060389.2  syntaxin-17

    See identical proteins and their annotated locations for NP_060389.2

    Status: VALIDATED

    Source sequence(s)
    AI375996, AL358937, BC101566, DC318495
    Consensus CDS
    CCDS6745.1
    UniProtKB/Swiss-Prot
    P56962
    Related
    ENSP00000259400.6, ENST00000259400.11
    Conserved Domains (2) summary
    COG5325
    Location:2228
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    cd15846
    Location:162223
    SNARE_syntaxin17; SNARE motif of syntaxin 17

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    99906654..99974541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447593.1XP_024303361.1  syntaxin-17 isoform X2

    Conserved Domains (1) summary
    cd15846
    Location:73134
    SNARE_syntaxin17; SNARE motif of syntaxin 17
  2. XM_011518821.3XP_011517123.1  syntaxin-17 isoform X1

    See identical proteins and their annotated locations for XP_011517123.1

    UniProtKB/Swiss-Prot
    P56962
    Related
    ENSP00000433484.1, ENST00000534052.1
    Conserved Domains (2) summary
    COG5325
    Location:2228
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    cd15846
    Location:162223
    SNARE_syntaxin17; SNARE motif of syntaxin 17
  3. XM_017014875.2XP_016870364.1  syntaxin-17 isoform X2

    Conserved Domains (1) summary
    cd15846
    Location:73134
    SNARE_syntaxin17; SNARE motif of syntaxin 17
  4. XM_011518820.3XP_011517122.1  syntaxin-17 isoform X1

    See identical proteins and their annotated locations for XP_011517122.1

    UniProtKB/Swiss-Prot
    P56962
    Conserved Domains (2) summary
    COG5325
    Location:2228
    COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    cd15846
    Location:162223
    SNARE_syntaxin17; SNARE motif of syntaxin 17
  5. XM_011518823.3XP_011517125.1  syntaxin-17 isoform X2

    See identical proteins and their annotated locations for XP_011517125.1

    Conserved Domains (1) summary
    cd15846
    Location:73134
    SNARE_syntaxin17; SNARE motif of syntaxin 17

RNA

  1. XR_001746332.1 RNA Sequence

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