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gtdc1 glycosyltransferase-like domain containing 1 [ Danio rerio (zebrafish) ]

Gene ID: 550132, updated on 9-Sep-2025
Official Symbol
gtdc1provided by ZNC
Official Full Name
glycosyltransferase-like domain containing 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-8
See related
Ensembl:ENSDARG00000020642 AllianceGenome:ZFIN:ZDB-GENE-050417-8
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
QTMAN; zgc:110568
Summary
Predicted to enable tRNA-queuosine(34) beta-mannosyltransferase activity. Acts upstream of or within central nervous system development. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human GTDC1 (glycosyltransferase like domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See gtdc1 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 9 NC_133184.1 (27468071..27540390)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 9 NC_007120.7 (25840720..25912990)

Chromosome 9 - NC_133184.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141376136 Neighboring gene zinc finger E-box binding homeobox 2a Neighboring gene uncharacterized LOC141376135 Neighboring gene Rho GTPase activating protein 15 Neighboring gene uncharacterized LOC137496474 Neighboring gene uncharacterized LOC137496426

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Personalized genome sequencing coupled with iPSC technology identifies GTDC1 as a gene involved in neurodevelopmental disorders. Aksoy I, et al. Hum Mol Genet, 2017 Jan 15. PMID 28365779
  2. Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth. Zhao X, et al. Cell, 2023 Dec 7. PMID 37992713
  3. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-queuosine(34) beta-mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-queuosine(34) beta-mannosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tRNA modification ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
tRNA-queuosine alpha-mannosyltransferase
Names
glycosyltransferase-like domain-containing protein 1
NP_001017560.1
XP_005167614.1
XP_073767951.1
XP_073767952.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017560.1 → NP_001017560.1  tRNA-queuosine alpha-mannosyltransferase

    See identical proteins and their annotated locations for NP_001017560.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092932
    UniProtKB/Swiss-Prot
    Q568B7
    Related
    ENSDARP00000016818.5, ENSDART00000024572.7
    Conserved Domains (4) summary
    cd01635
    Location:172 → 354
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    COG0438
    Location:255 → 421
    RfaB; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    pfam12038
    Location:2 → 164
    DUF3524; Domain of unknown function (DUF3524)
    cl10013
    Location:303 → 421
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133184.1 Reference GRCz12tu Primary Assembly

    Range
    27468071..27540390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167557.6 → XP_005167614.1  tRNA-queuosine alpha-mannosyltransferase isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z8E3
    Conserved Domains (4) summary
    cd01635
    Location:172 → 353
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    COG0438
    Location:254 → 420
    RfaB; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    pfam12038
    Location:2 → 164
    DUF3524; Domain of unknown function (DUF3524)
    cl10013
    Location:302 → 420
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

  2. XM_073911850.1 → XP_073767951.1  tRNA-queuosine alpha-mannosyltransferase isoform X1

    UniProtKB/Swiss-Prot
    B0S8J7, Q568B7

  3. XM_073911851.1 → XP_073767952.1  tRNA-queuosine alpha-mannosyltransferase isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z8E3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q568B7.2 GenPept UniProtKB/Swiss-Prot:Q568B7

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