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MCUB mitochondrial calcium uniporter dominant negative subunit beta [ Homo sapiens (human) ]

Gene ID: 55013, updated on 13-Mar-2020

Summary

Official Symbol
MCUBprovided by HGNC
Official Full Name
mitochondrial calcium uniporter dominant negative subunit betaprovided by HGNC
Primary source
HGNC:HGNC:26076
See related
Ensembl:ENSG00000005059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCDC109B
Expression
Broad expression in lymph node (RPKM 15.3), appendix (RPKM 10.9) and 21 other tissues See more
Orthologs

Genomic context

See MCUB in Genome Data Viewer
Location:
4q25
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (109560246..109688719)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (110481355..110608872)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene cell division cycle 42 pseudogene 4 Neighboring gene SET pseudogene 20 Neighboring gene uncharacterized LOC107986302 Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 14 Neighboring gene caspase 6 Neighboring gene phospholipase A2 group XIIA Neighboring gene complement factor I

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20647

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium channel inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT ion channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
calcium import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial calcium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial calcium ion transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
calcium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
intrinsic component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
uniplex complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
uniplex complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calcium uniporter regulatory subunit MCUb, mitochondrial
Names
coiled-coil domain containing 109B
coiled-coil domain-containing protein 109B
mitochondrial calcium uniporter dominant negative beta subunit
mitochondrial calcium uniporter regulatory subunit MCUb

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017918.5NP_060388.2  calcium uniporter regulatory subunit MCUb, mitochondrial

    See identical proteins and their annotated locations for NP_060388.2

    Status: VALIDATED

    Source sequence(s)
    AC004067, AK291098, BC002633, BM830891
    Consensus CDS
    CCDS3683.2
    UniProtKB/Swiss-Prot
    Q9NWR8
    Related
    ENSP00000378145.4, ENST00000394650.7
    Conserved Domains (1) summary
    pfam04678
    Location:102305
    MCU; Mitochondrial calcium uniporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    109560246..109688719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714246.3XP_006714309.1  calcium uniporter regulatory subunit MCUb, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam04678
    Location:73276
    MCU; Mitochondrial calcium uniporter
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