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PARPBP PARP1 binding protein [ Homo sapiens (human) ]

Gene ID: 55010, updated on 3-Apr-2024

Summary

Official Symbol
PARPBPprovided by HGNC
Official Full Name
PARP1 binding proteinprovided by HGNC
Primary source
HGNC:HGNC:26074
See related
Ensembl:ENSG00000185480 MIM:613687; AllianceGenome:HGNC:26074
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AROM; PARI; C12orf48
Summary
Predicted to enable DNA binding activity. Involved in negative regulation of double-strand break repair via homologous recombination. Located in chromatin and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bone marrow (RPKM 2.3), testis (RPKM 1.7) and 22 other tissues See more
Orthologs
NEW
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Genomic context

See PARPBP in Genome Data Viewer
Location:
12q23.2
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (102120183..102197520)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (102081315..102158656)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (102513961..102591298)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene WASH complex subunit 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6878 Neighboring gene nucleoporin 37 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6879 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:102514807-102515364 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:102546739-102547240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6880 Neighboring gene uncharacterized LOC124902998 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_22888 Neighboring gene pro-melanin concentrating hormone Neighboring gene RNA, 7SL, cytoplasmic 793, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ20641

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319988.2NP_001306917.1  PCNA-interacting partner isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC079907, AC087882
    Consensus CDS
    CCDS81728.1
    UniProtKB/TrEMBL
    B4DZ31
    Related
    ENSP00000440850.1, ENST00000541394.5
    Conserved Domains (1) summary
    TIGR01074
    Location:249393
    rep; ATP-dependent DNA helicase Rep
  2. NM_001319993.2NP_001306922.1  PCNA-interacting partner isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon and lacks an exon in the 5' region, and initiates translation at downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus and is shorter than isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AC079907, AC087882
    Consensus CDS
    CCDS81730.1
    Conserved Domains (1) summary
    TIGR01074
    Location:91235
    rep; ATP-dependent DNA helicase Rep
  3. NM_001319994.2NP_001306923.1  PCNA-interacting partner isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and lacks an exon in the 5' region, and initiates translation at downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus and is shorter than isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AC079907, AC087882
    Consensus CDS
    CCDS81730.1
    Related
    ENSP00000376643.2, ENST00000392911.6
    Conserved Domains (1) summary
    TIGR01074
    Location:91235
    rep; ATP-dependent DNA helicase Rep
  4. NM_001319995.3NP_001306924.1  PCNA-interacting partner isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate exon and lacks an exon in the 5' region, lacks multiple 3' coding exons, and contains an alternate 3' coding region and 3' UTR, compared to variant 1. It initiates translation at a downstream start codon. The encoded isoform (4) has a shorter N-terminus and a distinct C-terminus, and is shorter than isoform 1.
    Source sequence(s)
    AC087882, AF274940, BC070270, CA415422, DB260405
    UniProtKB/Swiss-Prot
    Q9NWS1
    UniProtKB/TrEMBL
    Q9BZU5
    Conserved Domains (1) summary
    TIGR01074
    Location:91140
    rep; ATP-dependent DNA helicase Rep
  5. NM_001319996.2NP_001306925.1  PCNA-interacting partner isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks multiple 3' coding exons and differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (5) has a shorter, distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC079907, AC087882
    Consensus CDS
    CCDS81729.1
    UniProtKB/TrEMBL
    G8JLI2
    Related
    ENSP00000442549.1, ENST00000537257.5
  6. NM_001382721.1NP_001369650.1  PCNA-interacting partner isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  7. NM_001382722.1NP_001369651.1  PCNA-interacting partner isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  8. NM_001382723.1NP_001369652.1  PCNA-interacting partner isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  9. NM_001382724.1NP_001369653.1  PCNA-interacting partner isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  10. NM_001382725.1NP_001369654.1  PCNA-interacting partner isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  11. NM_001382726.1NP_001369655.1  PCNA-interacting partner isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  12. NM_001382728.1NP_001369657.1  PCNA-interacting partner isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  13. NM_001382729.1NP_001369658.1  PCNA-interacting partner isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  14. NM_001382731.1NP_001369660.1  PCNA-interacting partner isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
    UniProtKB/TrEMBL
    J3KQY3
    Related
    ENSP00000411313.2, ENST00000417507.6
  15. NM_001382732.1NP_001369661.1  PCNA-interacting partner isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
    UniProtKB/TrEMBL
    A0A0C4DG30
    Related
    ENSP00000393867.2, ENST00000412715.3
  16. NM_001382735.1NP_001369664.1  PCNA-interacting partner isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
    Consensus CDS
    CCDS91743.1
    UniProtKB/TrEMBL
    B4DT40
    Related
    ENSP00000444576.1, ENST00000543784.5
  17. NM_001400853.1NP_001387782.1  PCNA-interacting partner isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  18. NM_001400854.1NP_001387783.1  PCNA-interacting partner isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  19. NM_001400855.1NP_001387784.1  PCNA-interacting partner isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  20. NM_001400856.1NP_001387785.1  PCNA-interacting partner isoform 20

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  21. NM_001400857.1NP_001387786.1  PCNA-interacting partner isoform 21

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  22. NM_001400858.1NP_001387787.1  PCNA-interacting partner isoform 22

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  23. NM_001400859.1NP_001387788.1  PCNA-interacting partner isoform 23

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  24. NM_001400860.1NP_001387789.1  PCNA-interacting partner isoform 23

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  25. NM_001400861.1NP_001387790.1  PCNA-interacting partner isoform 23

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  26. NM_001400862.1NP_001387791.1  PCNA-interacting partner isoform 24

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  27. NM_001400863.1NP_001387792.1  PCNA-interacting partner isoform 25

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  28. NM_001400864.1NP_001387793.1  PCNA-interacting partner isoform 26

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  29. NM_001400865.1NP_001387794.1  PCNA-interacting partner isoform 27

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  30. NM_001400866.1NP_001387795.1  PCNA-interacting partner isoform 28

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  31. NM_001400867.1NP_001387796.1  PCNA-interacting partner isoform 29

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  32. NM_001400868.1NP_001387797.1  PCNA-interacting partner isoform 30

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  33. NM_001400869.1NP_001387798.1  PCNA-interacting partner isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  34. NM_001400870.1NP_001387799.1  PCNA-interacting partner isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  35. NM_001400871.1NP_001387800.1  PCNA-interacting partner isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  36. NM_001400872.1NP_001387801.1  PCNA-interacting partner isoform 32

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  37. NM_001400873.1NP_001387802.1  PCNA-interacting partner isoform 33

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  38. NM_001400874.1NP_001387803.1  PCNA-interacting partner isoform 34

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  39. NM_001400875.1NP_001387804.1  PCNA-interacting partner isoform 35

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  40. NM_001400876.1NP_001387805.1  PCNA-interacting partner isoform 36

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  41. NM_001400877.1NP_001387806.1  PCNA-interacting partner isoform 37

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  42. NM_001400878.1NP_001387807.1  PCNA-interacting partner isoform 38

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  43. NM_001400879.1NP_001387808.1  PCNA-interacting partner isoform 39

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  44. NM_001400880.1NP_001387809.1  PCNA-interacting partner isoform 40

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  45. NM_001400881.1NP_001387810.1  PCNA-interacting partner isoform 41

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  46. NM_001400883.1NP_001387812.1  PCNA-interacting partner isoform 42

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  47. NM_001400884.1NP_001387813.1  PCNA-interacting partner isoform 43

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  48. NM_001400885.1NP_001387814.1  PCNA-interacting partner isoform 44

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  49. NM_001400886.1NP_001387815.1  PCNA-interacting partner isoform 45

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  50. NM_001400887.1NP_001387816.1  PCNA-interacting partner isoform 46

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  51. NM_001400888.1NP_001387817.1  PCNA-interacting partner isoform 46

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  52. NM_001400889.1NP_001387818.1  PCNA-interacting partner isoform 46

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  53. NM_001400890.1NP_001387819.1  PCNA-interacting partner isoform 47

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  54. NM_001400891.1NP_001387820.1  PCNA-interacting partner isoform 48

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  55. NM_001400892.1NP_001387821.1  PCNA-interacting partner isoform 49

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  56. NM_001400893.1NP_001387822.1  PCNA-interacting partner isoform 49

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  57. NM_001400894.1NP_001387823.1  PCNA-interacting partner isoform 49

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  58. NM_001400895.1NP_001387824.1  PCNA-interacting partner isoform 49

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  59. NM_001400896.1NP_001387825.1  PCNA-interacting partner isoform 50

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  60. NM_001400897.1NP_001387826.1  PCNA-interacting partner isoform 51

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  61. NM_001400902.1NP_001387831.1  PCNA-interacting partner isoform 52

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  62. NM_001400903.1NP_001387832.1  PCNA-interacting partner isoform 53

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  63. NM_001400904.1NP_001387833.1  PCNA-interacting partner isoform 54

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  64. NM_001400905.1NP_001387834.1  PCNA-interacting partner isoform 54

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  65. NM_001400906.1NP_001387835.1  PCNA-interacting partner isoform 55

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  66. NM_001400907.1NP_001387836.1  PCNA-interacting partner isoform 61

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  67. NM_001400925.1NP_001387854.1  PCNA-interacting partner isoform 56

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  68. NM_001400926.1NP_001387855.1  PCNA-interacting partner isoform 57

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  69. NM_001400927.1NP_001387856.1  PCNA-interacting partner isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
    Consensus CDS
    CCDS81729.1
  70. NM_001400928.1NP_001387857.1  PCNA-interacting partner isoform 59

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  71. NM_001400929.1NP_001387858.1  PCNA-interacting partner isoform 60

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  72. NM_017915.5NP_060385.3  PCNA-interacting partner isoform 2

    See identical proteins and their annotated locations for NP_060385.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC079907, AC087882
    Consensus CDS
    CCDS9090.2
    UniProtKB/Swiss-Prot
    B4E0Y0, Q05C00, Q499L8, Q4FZA0, Q4KMW7, Q6NSC6, Q6PJA1, Q86W36, Q9NWS1
    Related
    ENSP00000332915.3, ENST00000327680.7
    Conserved Domains (1) summary
    TIGR01074
    Location:172316
    rep; ATP-dependent DNA helicase Rep

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    102120183..102197520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429048.1XP_047285004.1  PCNA-interacting partner isoform X2

  2. XM_047429049.1XP_047285005.1  PCNA-interacting partner isoform X5

  3. XM_047429050.1XP_047285006.1  PCNA-interacting partner isoform X6

  4. XM_011538514.3XP_011536816.1  PCNA-interacting partner isoform X1

    See identical proteins and their annotated locations for XP_011536816.1

    Conserved Domains (1) summary
    TIGR01074
    Location:91235
    rep; ATP-dependent DNA helicase Rep
  5. XM_047429052.1XP_047285008.1  PCNA-interacting partner isoform X8

  6. XM_047429051.1XP_047285007.1  PCNA-interacting partner isoform X7

  7. XM_047429055.1XP_047285011.1  PCNA-interacting partner isoform X11

  8. XM_017019541.3XP_016875030.1  PCNA-interacting partner isoform X3

  9. XM_047429054.1XP_047285010.1  PCNA-interacting partner isoform X10

  10. XM_047429053.1XP_047285009.1  PCNA-interacting partner isoform X9

  11. XM_047429056.1XP_047285012.1  PCNA-interacting partner isoform X12

  12. XM_047429057.1XP_047285013.1  PCNA-interacting partner isoform X13

  13. XM_011538515.2XP_011536817.1  PCNA-interacting partner isoform X4

RNA

  1. XR_007063095.1 RNA Sequence

  2. XR_007063096.1 RNA Sequence

  3. XR_007063097.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    102081315..102158656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372369.1XP_054228344.1  PCNA-interacting partner isoform X2

  2. XM_054372372.1XP_054228347.1  PCNA-interacting partner isoform X5

  3. XM_054372373.1XP_054228348.1  PCNA-interacting partner isoform X6

  4. XM_054372368.1XP_054228343.1  PCNA-interacting partner isoform X1

  5. XM_054372375.1XP_054228350.1  PCNA-interacting partner isoform X8

  6. XM_054372374.1XP_054228349.1  PCNA-interacting partner isoform X7

  7. XM_054372378.1XP_054228353.1  PCNA-interacting partner isoform X11

  8. XM_054372370.1XP_054228345.1  PCNA-interacting partner isoform X3

  9. XM_054372377.1XP_054228352.1  PCNA-interacting partner isoform X10

  10. XM_054372376.1XP_054228351.1  PCNA-interacting partner isoform X9

  11. XM_054372379.1XP_054228354.1  PCNA-interacting partner isoform X12

  12. XM_054372380.1XP_054228355.1  PCNA-interacting partner isoform X13

  13. XM_054372371.1XP_054228346.1  PCNA-interacting partner isoform X4

RNA

  1. XR_008488627.1 RNA Sequence

  2. XR_008488628.1 RNA Sequence

  3. XR_008488629.1 RNA Sequence