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PARPBP PARP1 binding protein [ Homo sapiens (human) ]

Gene ID: 55010, updated on 1-Jun-2020

Summary

Official Symbol
PARPBPprovided by HGNC
Official Full Name
PARP1 binding proteinprovided by HGNC
Primary source
HGNC:HGNC:26074
See related
Ensembl:ENSG00000185480 MIM:613687
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AROM; PARI; C12orf48
Expression
Broad expression in bone marrow (RPKM 2.3), testis (RPKM 1.7) and 22 other tissues See more
Orthologs

Genomic context

See PARPBP in Genome Data Viewer
Location:
12q23.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (102120183..102197520)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (102513956..102591298)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene WASH complex subunit 3 Neighboring gene nucleoporin 37 Neighboring gene pro-melanin concentrating hormone Neighboring gene reticulon 3 pseudogene Neighboring gene RNA, 7SL, cytoplasmic 793, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20641

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
negative regulation of double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319988.2NP_001306917.1  PCNA-interacting partner isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC079907, AC087882
    Consensus CDS
    CCDS81728.1
    UniProtKB/Swiss-Prot
    Q9NWS1
    UniProtKB/TrEMBL
    B4DZ31
    Related
    ENSP00000440850.1, ENST00000541394.5
    Conserved Domains (1) summary
    TIGR01074
    Location:249393
    rep; ATP-dependent DNA helicase Rep
  2. NM_001319993.2NP_001306922.1  PCNA-interacting partner isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon and lacks an exon in the 5' region, and initiates translation at downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus and is shorter than isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AC079907, AC087882
    Consensus CDS
    CCDS81730.1
    UniProtKB/Swiss-Prot
    Q9NWS1
    UniProtKB/TrEMBL
    A0A024RBG0, B4DZ31
    Conserved Domains (1) summary
    TIGR01074
    Location:91235
    rep; ATP-dependent DNA helicase Rep
  3. NM_001319994.2NP_001306923.1  PCNA-interacting partner isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and lacks an exon in the 5' region, and initiates translation at downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus and is shorter than isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AC079907, AC087882
    Consensus CDS
    CCDS81730.1
    UniProtKB/Swiss-Prot
    Q9NWS1
    UniProtKB/TrEMBL
    A0A024RBG0, B4DT40
    Related
    ENSP00000376643.2, ENST00000392911.6
    Conserved Domains (1) summary
    TIGR01074
    Location:91235
    rep; ATP-dependent DNA helicase Rep
  4. NM_001319995.2NP_001306924.1  PCNA-interacting partner isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate exon and lacks an exon in the 5' region, lacks multiple 3' coding exons, and contains an alternate 3' coding region and 3' UTR, compared to variant 1. It initiates translation at a downstream start codon. The encoded isoform (4) has a shorter N-terminus and a distinct C-terminus, and is shorter than isoform 1.
    Source sequence(s)
    AC087882, AF274940, BC070270, CA415422, DB260405
    UniProtKB/Swiss-Prot
    Q9NWS1
    UniProtKB/TrEMBL
    Q9BZU5
    Conserved Domains (1) summary
    TIGR01074
    Location:91140
    rep; ATP-dependent DNA helicase Rep
  5. NM_001319996.2NP_001306925.1  PCNA-interacting partner isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks multiple 3' coding exons and differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (5) has a shorter, distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC079907, AC087882
    Consensus CDS
    CCDS81729.1
    UniProtKB/Swiss-Prot
    Q9NWS1
    Related
    ENSP00000442549.1, ENST00000537257.5
  6. NM_001382721.1NP_001369650.1  PCNA-interacting partner isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  7. NM_001382722.1NP_001369651.1  PCNA-interacting partner isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  8. NM_001382723.1NP_001369652.1  PCNA-interacting partner isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  9. NM_001382724.1NP_001369653.1  PCNA-interacting partner isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  10. NM_001382725.1NP_001369654.1  PCNA-interacting partner isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  11. NM_001382726.1NP_001369655.1  PCNA-interacting partner isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  12. NM_001382728.1NP_001369657.1  PCNA-interacting partner isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  13. NM_001382729.1NP_001369658.1  PCNA-interacting partner isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  14. NM_001382731.1NP_001369660.1  PCNA-interacting partner isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  15. NM_001382732.1NP_001369661.1  PCNA-interacting partner isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  16. NM_001382735.1NP_001369664.1  PCNA-interacting partner isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC079907, AC087882
  17. NM_017915.5NP_060385.3  PCNA-interacting partner isoform 2

    See identical proteins and their annotated locations for NP_060385.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC079907, AC087882
    Consensus CDS
    CCDS9090.2
    UniProtKB/Swiss-Prot
    Q9NWS1
    UniProtKB/TrEMBL
    B4DT40
    Related
    ENSP00000332915.3, ENST00000327680.6
    Conserved Domains (1) summary
    TIGR01074
    Location:172316
    rep; ATP-dependent DNA helicase Rep

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    102120183..102197520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538514.2XP_011536816.1  PCNA-interacting partner isoform X3

    See identical proteins and their annotated locations for XP_011536816.1

    UniProtKB/TrEMBL
    A0A024RBG0
    Conserved Domains (1) summary
    TIGR01074
    Location:91235
    rep; ATP-dependent DNA helicase Rep
  2. XM_024449028.1XP_024304796.1  PCNA-interacting partner isoform X10

  3. XM_017019541.2XP_016875030.1  PCNA-interacting partner isoform X9

  4. XM_017019535.1XP_016875024.1  PCNA-interacting partner isoform X3

    UniProtKB/TrEMBL
    A0A024RBG0
    Conserved Domains (1) summary
    TIGR01074
    Location:91235
    rep; ATP-dependent DNA helicase Rep
  5. XM_011538515.1XP_011536817.1  PCNA-interacting partner isoform X10

RNA

  1. XR_001748776.2 RNA Sequence

  2. XR_001748775.2 RNA Sequence

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