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FAM118A family with sequence similarity 118 member A [ Homo sapiens (human) ]

Gene ID: 55007, updated on 7-Jun-2020

Summary

Official Symbol
FAM118Aprovided by HGNC
Official Full Name
family with sequence similarity 118 member Aprovided by HGNC
Primary source
HGNC:HGNC:1313
See related
Ensembl:ENSG00000100376
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C22orf8
Expression
Broad expression in prostate (RPKM 10.4), lymph node (RPKM 9.2) and 23 other tissues See more
Orthologs

Genomic context

See FAM118A in Genome Data Viewer
Location:
22q13.31
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (45308960..45341955)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (45705081..45737836)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10 pseudogene 31 Neighboring gene uroplakin 3A Neighboring gene structural maintenance of chromosomes 1B Neighboring gene RIB43A domain with coiled-coils 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of family with sequence similarity 118, member A (FAM118A; C22orf8) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20635

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein FAM118A
Names
bK268H5.C22.4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001104595.2NP_001098065.1  protein FAM118A isoform 1

    See identical proteins and their annotated locations for NP_001098065.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1 - 3 encode the same protein (isoform 1).
    Source sequence(s)
    AL008718
    Consensus CDS
    CCDS14065.1
    UniProtKB/Swiss-Prot
    Q9NWS6
    UniProtKB/TrEMBL
    A0A024R4V3
    Related
    ENSP00000216214.3, ENST00000216214.7
    Conserved Domains (1) summary
    pfam13289
    Location:143247
    SIR2_2; SIR2-like domain
  2. NM_001349913.1NP_001336842.1  protein FAM118A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes isoform 1. Variants 1 - 3 encode the same protein (isoform 1).
    Source sequence(s)
    AL008718
    Consensus CDS
    CCDS14065.1
    Conserved Domains (1) summary
    pfam13289
    Location:143247
    SIR2_2; SIR2-like domain
  3. NM_001349914.1NP_001336843.1  protein FAM118A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes isoform 2.
    Source sequence(s)
    AL008718
    Conserved Domains (1) summary
    pfam13289
    Location:144248
    SIR2_2; SIR2-like domain
  4. NM_001349915.1NP_001336844.1  protein FAM118A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes isoform 3.
    Source sequence(s)
    AL008718
    Conserved Domains (1) summary
    cl00195
    Location:113173
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  5. NM_001349916.1NP_001336845.1  protein FAM118A isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) encodes isoform 4.
    Source sequence(s)
    AL008718
    Conserved Domains (1) summary
    pfam13289
    Location:157261
    SIR2_2; SIR2-like domain
  6. NM_017911.4NP_060381.2  protein FAM118A isoform 1

    See identical proteins and their annotated locations for NP_060381.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes isoform 1. Variants 1 - 3 encode the same protein (isoform 1).
    Source sequence(s)
    AL008718
    Consensus CDS
    CCDS14065.1
    UniProtKB/Swiss-Prot
    Q9NWS6
    UniProtKB/TrEMBL
    A0A024R4V3
    Related
    ENSP00000395892.2, ENST00000441876.7
    Conserved Domains (1) summary
    pfam13289
    Location:143247
    SIR2_2; SIR2-like domain

RNA

  1. NR_146323.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL008718

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    45308960..45341955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452256.1XP_024308024.1  protein FAM118A isoform X12

    Conserved Domains (1) summary
    cl00195
    Location:2484
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  2. XM_017028861.1XP_016884350.1  protein FAM118A isoform X16

  3. XM_017028850.1XP_016884339.1  protein FAM118A isoform X8

  4. XM_017028858.1XP_016884347.1  protein FAM118A isoform X15

    Related
    ENSP00000385231.1, ENST00000405673.5
  5. XM_017028846.1XP_016884335.1  protein FAM118A isoform X7

  6. XM_017028857.1XP_016884346.1  protein FAM118A isoform X14

  7. XM_024452257.1XP_024308025.1  protein FAM118A isoform X12

    Conserved Domains (1) summary
    cl00195
    Location:2484
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  8. XM_017028847.2XP_016884336.1  protein FAM118A isoform X7

  9. XM_017028851.1XP_016884340.1  protein FAM118A isoform X8

  10. XM_017028848.1XP_016884337.1  protein FAM118A isoform X7

  11. XM_017028852.1XP_016884341.1  protein FAM118A isoform X8

  12. XM_017028845.1XP_016884334.1  protein FAM118A isoform X6

    Conserved Domains (1) summary
    cl00195
    Location:128188
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  13. XM_011530254.3XP_011528556.1  protein FAM118A isoform X2

    Conserved Domains (1) summary
    cl00195
    Location:163224
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  14. XM_017028856.2XP_016884345.1  protein FAM118A isoform X13

  15. XM_017028849.1XP_016884338.1  protein FAM118A isoform X7

  16. XM_011530247.3XP_011528549.1  protein FAM118A isoform X6

    Conserved Domains (1) summary
    cl00195
    Location:128188
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  17. XM_017028842.1XP_016884331.1  protein FAM118A isoform X3

  18. XM_017028844.1XP_016884333.1  protein FAM118A isoform X5

  19. XM_017028841.1XP_016884330.1  protein FAM118A isoform X1

  20. XM_017028843.1XP_016884332.1  protein FAM118A isoform X4

  21. XM_011530256.1XP_011528558.1  protein FAM118A isoform X9

  22. XM_024452254.1XP_024308022.1  protein FAM118A isoform X10

  23. XM_024452255.1XP_024308023.1  protein FAM118A isoform X11

RNA

  1. XR_002958709.1 RNA Sequence

  2. XR_002958708.1 RNA Sequence

  3. XR_002958706.1 RNA Sequence

  4. XR_002958707.1 RNA Sequence

  5. XR_002958705.1 RNA Sequence

  6. XR_001755255.1 RNA Sequence

  7. XR_001755256.1 RNA Sequence

  8. XR_001755254.1 RNA Sequence

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