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TRMT61B tRNA methyltransferase 61B [ Homo sapiens (human) ]

Gene ID: 55006, updated on 6-Sep-2022

Summary

Official Symbol
TRMT61Bprovided by HGNC
Official Full Name
tRNA methyltransferase 61Bprovided by HGNC
Primary source
HGNC:HGNC:26070
See related
Ensembl:ENSG00000171103 MIM:619404; AllianceGenome:HGNC:26070
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables mRNA (adenine-N1-)-methyltransferase activity; rRNA (adenine) methyltransferase activity; and tRNA (adenine-N1-)-methyltransferase activity. Involved in mRNA methylation; mitochondrial tRNA methylation; and protein homooligomerization. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 8.4), small intestine (RPKM 6.4) and 25 other tissues See more
Orthologs
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Genomic context

See TRMT61B in Genome Data Viewer
Location:
2p23.2
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (28849821..28870309, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (28893430..28913902, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (29072687..29093175, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100505774 Neighboring gene PPP1CB divergent transcript Neighboring gene protein phosphatase 1 catalytic subunit beta Neighboring gene speedy/RINGO cell cycle regulator family member A Neighboring gene WD repeat domain 43 Neighboring gene small nucleolar RNA, C/D box 92 Neighboring gene small nucleolar RNA, C/D box 53

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20628, DKFZp564I2178

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in mRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrial tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial tRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in rRNA methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
part_of tRNA (m1A) methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial
Names
mRNA methyladenosine-N(1)-methyltransferase
potential tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61B
potential tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61B
tRNA methyltransferase 61 homolog B
NP_060380.3
XP_005264450.1
XP_006712100.1
XP_016859890.1
XP_016859892.1
XP_047300796.1
XP_047300797.1
XP_047300798.1
XP_047300799.1
XP_047300800.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017910.4NP_060380.3  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_060380.3

    Status: VALIDATED

    Source sequence(s)
    AC097720, AL136689, BC000952
    Consensus CDS
    CCDS1768.1
    UniProtKB/Swiss-Prot
    Q9BVS5, Q9NWS7
    Related
    ENSP00000302801.5, ENST00000306108.10
    Conserved Domains (1) summary
    cl25960
    Location:150474
    GCD14_N; tRNA methyltransferase complex GCD14 subunit N-term

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    28849821..28870309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444843.1XP_047300799.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X7

  2. XM_017004401.3XP_016859890.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X3

  3. XM_006712037.4XP_006712100.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X2

    Conserved Domains (2) summary
    COG2519
    Location:150376
    Gcd14; tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]
    pfam10577
    Location:43141
    UPF0560; uncharacterized protein family UPF0560
  4. XM_047444841.1XP_047300797.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X5

    UniProtKB/TrEMBL
    F8WDR2
    Related
    ENSP00000389617.1, ENST00000439947.1
  5. XM_005264393.4XP_005264450.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X1

    Conserved Domains (3) summary
    COG2519
    Location:150465
    Gcd14; tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]
    pfam10577
    Location:43141
    UPF0560; uncharacterized protein family UPF0560
    cl17173
    Location:227457
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  6. XM_017004403.2XP_016859892.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X9

  7. XM_047444840.1XP_047300796.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X4

  8. XM_047444842.1XP_047300798.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X6

  9. XM_047444844.1XP_047300800.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X8

RNA

  1. XR_939691.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    28893430..28913902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)