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TTC22 tetratricopeptide repeat domain 22 [ Homo sapiens (human) ]

Gene ID: 55001, updated on 23-Nov-2021

Summary

Official Symbol
TTC22provided by HGNC
Official Full Name
tetratricopeptide repeat domain 22provided by HGNC
Primary source
HGNC:HGNC:26067
See related
Ensembl:ENSG00000006555
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein with seven tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]
Expression
Biased expression in esophagus (RPKM 8.5), colon (RPKM 4.0) and 12 other tissues See more
Orthologs
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Genomic context

See TTC22 in Genome Data Viewer
Location:
1p32.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (54779696..54802379, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (55245385..55266996, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MROH7-TTC4 readthrough (NMD candidate) Neighboring gene tetratricopeptide repeat domain 4 Neighboring gene prolyl-tRNA synthetase 2, mitochondrial Neighboring gene lymphocyte expansion molecule Neighboring gene 24-dehydrocholesterol reductase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20619

General protein information

Preferred Names
tetratricopeptide repeat protein 22
Names
TPR repeat protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029054.1 RefSeqGene

    Range
    5001..25190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001114108.2NP_001107580.1  tetratricopeptide repeat protein 22 isoform 1

    See identical proteins and their annotated locations for NP_001107580.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC096536, AL139244
    Consensus CDS
    CCDS44152.1
    UniProtKB/Swiss-Prot
    Q5TAA0
    Related
    ENSP00000360323.4, ENST00000371276.9
    Conserved Domains (1) summary
    sd00006
    Location:6595
    TPR; TPR repeat [structural motif]
  2. NM_017904.4NP_060374.2  tetratricopeptide repeat protein 22 isoform 2

    See identical proteins and their annotated locations for NP_060374.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC096536, AL139244
    Consensus CDS
    CCDS598.1
    UniProtKB/Swiss-Prot
    Q5TAA0
    Related
    ENSP00000360321.4, ENST00000371274.8
    Conserved Domains (1) summary
    sd00006
    Location:6595
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    54779696..54802379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001582.1XP_016857071.1  tetratricopeptide repeat protein 22 isoform X2

  2. XM_011541671.2XP_011539973.1  tetratricopeptide repeat protein 22 isoform X1

    Conserved Domains (1) summary
    sd00006
    Location:294324
    TPR; TPR repeat [structural motif]
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