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AURKAIP1 aurora kinase A interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 54998, updated on 8-Dec-2022

Summary

Official Symbol
AURKAIP1provided by HGNC
Official Full Name
aurora kinase A interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:24114
See related
Ensembl:ENSG00000175756 MIM:609183; AllianceGenome:HGNC:24114
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIP; AKIP; MRP-S38
Summary
Acts upstream of or within positive regulation of proteolysis. Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 40.0), kidney (RPKM 27.3) and 25 other tissues See more
Orthologs
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Genomic context

See AURKAIP1 in Genome Data Viewer
Location:
1p36.33
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1373736..1375207, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (804285..805756, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1309116..1310587, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene matrix remodeling associated 8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1307318-1308085 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 8 Neighboring gene cyclin L2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20608

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
part_of mitochondrial small ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
aurora kinase A-interacting protein
Names
28S ribosomal protein S38, mitochondrial
AURKA-interacting protein
aurora-A kinase interacting protein
mitochondrial small ribosomal subunit protein mS38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127229.2NP_001120701.1  aurora kinase A-interacting protein

    See identical proteins and their annotated locations for NP_001120701.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a 5'UTR resulting from use of an alternate splice donor site.
    Source sequence(s)
    AK000615, AL139287, AW576100, BM781908, F31434
    Consensus CDS
    CCDS25.1
    UniProtKB/Swiss-Prot
    Q8TBD3, Q9NWT8
    UniProtKB/TrEMBL
    A0A024R0F0
    Related
    ENSP00000368130.3, ENST00000378853.3
    Conserved Domains (1) summary
    pfam08213
    Location:127157
    DUF1713; Mitochondrial domain of unknown function (DUF1713)
  2. NM_001127230.2NP_001120702.1  aurora kinase A-interacting protein

    See identical proteins and their annotated locations for NP_001120702.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a 5'UTR resulting from use of an alternate splice donor site.
    Source sequence(s)
    AL139287, BC022808, BC062333, BE903314, BP198074, DN994953
    Consensus CDS
    CCDS25.1
    UniProtKB/Swiss-Prot
    Q8TBD3, Q9NWT8
    UniProtKB/TrEMBL
    A0A024R0F0
    Related
    ENSP00000319778.5, ENST00000321751.9
    Conserved Domains (1) summary
    pfam08213
    Location:127157
    DUF1713; Mitochondrial domain of unknown function (DUF1713)
  3. NM_017900.3NP_060370.1  aurora kinase A-interacting protein

    See identical proteins and their annotated locations for NP_060370.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has a 5'UTR resulting from use of an alternate splice donor site.
    Source sequence(s)
    BC062333, BG764236
    Consensus CDS
    CCDS25.1
    UniProtKB/Swiss-Prot
    Q8TBD3, Q9NWT8
    UniProtKB/TrEMBL
    A0A024R0F0
    Related
    ENSP00000340656.5, ENST00000338338.10
    Conserved Domains (1) summary
    pfam08213
    Location:127157
    DUF1713; Mitochondrial domain of unknown function (DUF1713)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    1373736..1375207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    804285..805756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)