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TESC tescalcin [ Homo sapiens (human) ]

Gene ID: 54997, updated on 22-Sep-2022

Summary

Official Symbol
TESCprovided by HGNC
Official Full Name
tescalcinprovided by HGNC
Primary source
HGNC:HGNC:26065
See related
Ensembl:ENSG00000088992 MIM:611585; AllianceGenome:HGNC:26065
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSC; CHP3
Summary
Enables calcium ion binding activity. Involved in several processes, including cellular response to retinoic acid; positive regulation of macromolecule metabolic process; and positive regulation of myeloid cell differentiation. Located in several cellular components, including cytosol; lamellipodium; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in salivary gland (RPKM 66.0), stomach (RPKM 63.6) and 14 other tissues See more
Orthologs
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Genomic context

See TESC in Genome Data Viewer
Location:
12q24.22
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (117038923..117099416, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (117019980..117080464, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (117476728..117537221, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36 pseudogene 15 Neighboring gene F-box and WD repeat domain containing 8 Neighboring gene uncharacterized LOC100506551 Neighboring gene uncharacterized LOC105370010 Neighboring gene TESC antisense RNA 1 (head to head) Neighboring gene F-box protein 21

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20607

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of granulocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of granulocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of megakaryocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of sodium:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell adhesion mediated by integrin IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcineurin B homologous protein 3
Names
calcineurin-like EF hand protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168325.2NP_001161797.1  calcineurin B homologous protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001161797.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AI372964, AI910454, BQ949772, DB452909
    Consensus CDS
    CCDS53835.1
    UniProtKB/Swiss-Prot
    Q96BS2
    Related
    ENSP00000445689.1, ENST00000541210.5
    Conserved Domains (1) summary
    pfam13499
    Location:85132
    EF-hand_7; EF-hand domain pair
  2. NM_017899.4NP_060369.3  calcineurin B homologous protein 3 isoform 1

    See identical proteins and their annotated locations for NP_060369.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AI372964, BC015221, DB452909
    Consensus CDS
    CCDS9183.3
    UniProtKB/Swiss-Prot
    Q96BS2, Q9NWT9
    Related
    ENSP00000334785.7, ENST00000335209.12
    Conserved Domains (1) summary
    COG5126
    Location:20142
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RNA

  1. NR_031766.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI372964, BM666793, BQ434057, DB452909
    Related
    ENST00000470612.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    117038923..117099416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429044.1XP_047285000.1  calcineurin B homologous protein 3 isoform X2

  2. XM_017019532.2XP_016875021.2  calcineurin B homologous protein 3 isoform X1

  3. XM_011538503.1XP_011536805.1  calcineurin B homologous protein 3 isoform X3

    Conserved Domains (2) summary
    COG5126
    Location:7130
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cl08302
    Location:102130
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    117019980..117080464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)