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ZSCAN2 zinc finger and SCAN domain containing 2 [ Homo sapiens (human) ]

Gene ID: 54993, updated on 4-Oct-2020

Summary

Official Symbol
ZSCAN2provided by HGNC
Official Full Name
zinc finger and SCAN domain containing 2provided by HGNC
Primary source
HGNC:HGNC:20994
See related
Ensembl:ENSG00000176371
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP29; ZNF854
Summary
The protein encoded by this gene contains several copies of zinc finger motif, which is commonly found in transcriptional regulatory proteins. Studies in mice show that this gene is expressed during embryonic development, and specifically in the testis in adult mice, suggesting that it may play a role in regulating genes in germ cells. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 2.7), testis (RPKM 2.7) and 25 other tissues See more
Orthologs

Genomic context

See ZSCAN2 in Genome Data Viewer
Location:
15q25.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (84601009..84623718)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (85144249..85166947)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene golgin A6 family like 5, pseudogene Neighboring gene ubiquitin conjugating enzyme E2 Q2 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 933 Neighboring gene uncharacterized LOC105370947 Neighboring gene SCAN domain containing 2 pseudogene Neighboring gene egl-9 family hypoxia inducible factor 1 pseudogene 1 Neighboring gene WD repeat domain 73

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20595

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger and SCAN domain-containing protein 2
Names
zfp-29
zinc finger protein 29 homolog
zinc finger protein 854

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047160.1 RefSeqGene

    Range
    5024..27731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001007072.2NP_001007073.1  zinc finger and SCAN domain-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001007073.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has a different 3' terminal exon compared to transcript variants 1 and 2, resulting in the shortest isoform (3) with a distinct C-terminus.
    Source sequence(s)
    AC048382, AW452266, AY279349, BC041620
    Consensus CDS
    CCDS32315.1
    UniProtKB/Swiss-Prot
    Q7Z7L9
    Related
    ENSP00000368663.3, ENST00000379358.7
    Conserved Domains (1) summary
    pfam02023
    Location:72134
    SCAN; SCAN domain
  2. NM_017894.6NP_060364.4  zinc finger and SCAN domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_060364.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a different 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (2) with a distinct C-terminus.
    Source sequence(s)
    AC048382, BC041620
    Consensus CDS
    CCDS32316.1
    UniProtKB/Swiss-Prot
    Q7Z7L9
    UniProtKB/TrEMBL
    A0A024RC69
    Related
    ENSP00000333895.3, ENST00000334141.7
    Conserved Domains (1) summary
    pfam02023
    Location:72134
    SCAN; SCAN domain
  3. NM_181877.4NP_870992.2  zinc finger and SCAN domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_870992.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC048382, AK128624, AY262259, BC041620, BU733585, CK003500
    Consensus CDS
    CCDS10329.2
    UniProtKB/Swiss-Prot
    Q7Z7L9
    Related
    ENSP00000445451.1, ENST00000546148.6
    Conserved Domains (3) summary
    COG5048
    Location:220600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:364384
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:72134
    SCAN; SCAN domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    84601009..84623718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449975.1XP_024305743.1  zinc finger and SCAN domain-containing protein 2 isoform X1

    Related
    ENSP00000410198.2, ENST00000448803.6
    Conserved Domains (3) summary
    COG5048
    Location:220600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:364384
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:72134
    SCAN; SCAN domain
  2. XM_024449978.1XP_024305746.1  zinc finger and SCAN domain-containing protein 2 isoform X5

    Conserved Domains (3) summary
    COG5048
    Location:251631
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:395415
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:70157
    SCAN; SCAN oligomerization domain
  3. XM_017022393.2XP_016877882.1  zinc finger and SCAN domain-containing protein 2 isoform X4

  4. XM_024449977.1XP_024305745.1  zinc finger and SCAN domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    pfam02023
    Location:72134
    SCAN; SCAN domain
  5. XM_024449976.1XP_024305744.1  zinc finger and SCAN domain-containing protein 2 isoform X2

    Related
    ENSP00000351257.3, ENST00000358472.3
    Conserved Domains (2) summary
    COG5048
    Location:70450
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214234
    ZF_C2H2; C2H2 Zn finger [structural motif]
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