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ZNF770 zinc finger protein 770 [ Homo sapiens (human) ]

Gene ID: 54989, updated on 5-Jul-2025
Official Symbol
ZNF770provided by HGNC
Official Full Name
zinc finger protein 770provided by HGNC
Primary source
HGNC:HGNC:26061
See related
Ensembl:ENSG00000198146 AllianceGenome:HGNC:26061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRO1914
Summary
Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in thyroid (RPKM 32.4), skin (RPKM 18.5) and 24 other tissues See more
Orthologs
mouse all
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See ZNF770 in Genome Data Viewer
Location:
15q14
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (34978341..34988287, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (32783551..32793491, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (35270542..35280488, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene tubulin alpha pseudogene 11 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:35166353-35167552 Neighboring gene aquarius intron-binding spliceosomal factor Neighboring gene Sharpr-MPRA regulatory region 15538 Neighboring gene ribosomal protein L36a pseudogene 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:35260004-35260568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9184 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:35277351-35278003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9185 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9186 Neighboring gene uncharacterized LOC105370764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9187 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:35285419-35286618 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:35287050-35287721 Neighboring gene uncharacterized LOC105370763 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:35312331-35313023 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:35345268-35345500 Neighboring gene uncharacterized LOC105370765 Neighboring gene Nanog homeobox retrogene P8

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. A genome-wide association study (GWAS) for bronchopulmonary dysplasia. Wang H, et al. Pediatrics, 2013 Aug. PMID 23897914, Free PMC Article
  2. Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations. Connaughton DM, et al. Am J Hum Genet, 2020 Oct 1. PMID 32891193, Free PMC Article
  3. UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair. Huang Q, et al. FASEB J, 2022 Jan. PMID 34921745
  4. CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system. Lim SH, et al. Mol Syst Biol, 2022 Feb. PMID 35156780, Free PMC Article
  5. The in vivo Interaction Landscape of Histones H3.1 and H3.3. Siddaway R, et al. Mol Cell Proteomics, 2022 Oct. PMID 36089195, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ20582

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
zinc finger protein 770

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014106.4 → NP_054825.2  zinc finger protein 770

    See identical proteins and their annotated locations for NP_054825.2

    Status: VALIDATED

    Source sequence(s)
    AC114546, AI031776, AK127201, AK131433, BC071603, DA331762
    Consensus CDS
    CCDS10042.1
    UniProtKB/Swiss-Prot
    Q6IQ21, Q6ZMZ6, Q9NWV2
    UniProtKB/TrEMBL
    A8K5X3
    Related
    ENSP00000348673.4, ENST00000356321.4
    Conserved Domains (3) summary
    COG5048
    Location:185 → 530
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:162 → 182
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:42 → 66
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    34978341..34988287 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521744.4 → XP_011520046.1  zinc finger protein 770 isoform X1

    See identical proteins and their annotated locations for XP_011520046.1

    UniProtKB/Swiss-Prot
    Q6IQ21, Q6ZMZ6, Q9NWV2
    UniProtKB/TrEMBL
    A8K5X3
    Conserved Domains (3) summary
    COG5048
    Location:185 → 530
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:162 → 182
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:42 → 66
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    32783551..32793491 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378346.1 → XP_054234321.1  zinc finger protein 770 isoform X1

    UniProtKB/Swiss-Prot
    Q6IQ21, Q6ZMZ6, Q9NWV2
    UniProtKB/TrEMBL
    A8K5X3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IQ21.1 GenPept UniProtKB/Swiss-Prot:Q6IQ21

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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