ZNF770 zinc finger protein 770 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF770provided by HGNC
Official Full Name: zinc finger protein 770provided by HGNC
Primary source: HGNC:HGNC:26061
See related: Ensembl:ENSG00000198146 AllianceGenome:HGNC:26061
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PRO1914
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thyroid (RPKM 32.4), skin (RPKM 18.5) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q14

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (34978341..34988287, complement)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (32783551..32793491, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (35270542..35280488, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study (GWAS) for bronchopulmonary dysplasia. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

RH66164 (e-PCR)
- UniSTS:9062

D11S3114 (e-PCR)
- UniSTS:152207

RH46359 (e-PCR)
- UniSTS:41402

D15S951 (e-PCR)
- UniSTS:35837

Homology

Homologs of the ZNF770 gene: The ZNF770 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 329 organisms have orthologs with human gene ZNF770
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 770

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014106.4 → NP_054825.2 zinc finger protein 770

See identical proteins and their annotated locations for NP_054825.2

Status: VALIDATED

Source sequence(s)

AC114546, AI031776, AK127201, AK131433, BC071603, DA331762

Consensus CDS

CCDS10042.1

UniProtKB/Swiss-Prot

Q6IQ21, Q9NWV2

Related

ENSP00000348673.4, ENST00000356321.4

Conserved Domains (3) summary

COG5048
Location:185 → 530

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:162 → 182

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:42 → 66

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000015.10 Reference GRCh38.p14 Primary Assembly

Range

34978341..34988287 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011521744.4 → XP_011520046.1 zinc finger protein 770 isoform X1

See identical proteins and their annotated locations for XP_011520046.1

UniProtKB/Swiss-Prot

Q6IQ21, Q9NWV2

Conserved Domains (3) summary

COG5048
Location:185 → 530

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:162 → 182

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:42 → 66

zf-H2C2_2; Zinc-finger double domain