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ZNF770 zinc finger protein 770 [ Homo sapiens (human) ]

Gene ID: 54989, updated on 23-Nov-2021

Summary

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Official Symbol
ZNF770provided by HGNC
Official Full Name
zinc finger protein 770provided by HGNC
Primary source
HGNC:HGNC:26061
See related
Ensembl:ENSG00000198146
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRO1914
Expression
Ubiquitous expression in thyroid (RPKM 32.4), skin (RPKM 18.5) and 24 other tissues See more
Orthologs
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Genomic context

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See ZNF770 in Genome Data Viewer
Location:
15q14
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (34978341..34988287, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (35270542..35280488, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene tubulin alpha pseudogene 11 Neighboring gene aquarius intron-binding spliceosomal factor Neighboring gene ribosomal protein L36a pseudogene 8 Neighboring gene uncharacterized LOC105370764 Neighboring gene uncharacterized LOC105370763 Neighboring gene uncharacterized LOC105370765 Neighboring gene Nanog homeobox retrogene P8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A genome-wide association study (GWAS) for bronchopulmonary dysplasia. Wang H, et al. Pediatrics, 2013 Aug. PMID 23897914, Free PMC Article
  2. Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732, Free PMC Article
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610

See all (13) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20582

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 770

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014106.4 → NP_054825.2  zinc finger protein 770

    See identical proteins and their annotated locations for NP_054825.2

    Status: VALIDATED

    Source sequence(s)
    AC114546, AI031776, AK127201, AK131433, BC071603, DA331762
    Consensus CDS
    CCDS10042.1
    UniProtKB/Swiss-Prot
    Q6IQ21
    Related
    ENSP00000348673.4, ENST00000356321.4
    Conserved Domains (3) summary
    COG5048
    Location:185 → 530
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:162 → 182
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:42 → 66
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    34978341..34988287 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521744.3 → XP_011520046.1  zinc finger protein 770 isoform X1

    See identical proteins and their annotated locations for XP_011520046.1

    UniProtKB/Swiss-Prot
    Q6IQ21
    Conserved Domains (3) summary
    COG5048
    Location:185 → 530
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:162 → 182
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:42 → 66
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IQ21.1 GenPept UniProtKB/Swiss-Prot:Q6IQ21

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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