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ULK4 unc-51 like kinase 4 [ Homo sapiens (human) ]

Gene ID: 54986, updated on 25-Nov-2021

Summary

Official Symbol
ULK4provided by HGNC
Official Full Name
unc-51 like kinase 4provided by HGNC
Primary source
HGNC:HGNC:15784
See related
Ensembl:ENSG00000168038 MIM:617010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM7C1; REC01035
Summary
This gene encodes a member of the unc-51-like serine/threonine kinase (STK) family. Members of this protein family play a role in neuronal growth and endocytosis. The encoded protein is likely involved in neurite branching, neurite elongation and neuronal migration. Genome-wide association studies (GWAS) indicate an association of variations in this gene with blood pressure and hypertension. Sequence variations in this gene may also be be associated with psychiatric disorders, including schizophrenia and bipolar disorder. Pseudogenes associated with this gene have been identified and are located on chromosome 15. [provided by RefSeq, Jul 2016]
Expression
Broad expression in testis (RPKM 5.0), thyroid (RPKM 0.8) and 16 other tissues See more
Orthologs
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Genomic context

See ULK4 in Genome Data Viewer
Location:
3p22.1
Exon count:
40
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (41246599..41962103, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (41288090..42003595, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S31 pseudogene 1 Neighboring gene uncharacterized LOC105377046 Neighboring gene catenin beta 1 Neighboring gene rRNA-processing protein FCF1 homolog pseudogene Neighboring gene RN7SK pseudogene 58 Neighboring gene ATPase H+ transporting V0 subunit e1 pseudogene 2 Neighboring gene uncharacterized LOC107986077 Neighboring gene ribosomal protein L36 pseudogene 20 Neighboring gene gem nuclear organelle associated protein 2 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk.
GeneReviews: Not available
Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.
GeneReviews: Not available
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
GeneReviews: Not available
Genome-wide association study of blood pressure and hypertension.
GeneReviews: Not available
The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with ULK4 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20574, DKFZp434E1822

General protein information

Preferred Names
serine/threonine-protein kinase ULK4
NP_001309429.1
NP_001309430.1
NP_060356.2
XP_011532182.1
XP_024309380.1
XP_024309381.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051047.1 RefSeqGene

    Range
    5918..721422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322500.2NP_001309429.1  serine/threonine-protein kinase ULK4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC097356, AC099059, AC099537, AC104305, AC137935
    Conserved Domains (4) summary
    smart00220
    Location:4279
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00020
    Location:646756
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    cd14010
    Location:3280
    STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
    cl10013
    Location:486563
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
  2. NM_001322501.2NP_001309430.1  serine/threonine-protein kinase ULK4 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC097356, AC099059, AC099537, AC104305, AC104307, AC137935, BC018795
    Conserved Domains (2) summary
    cd00020
    Location:344454
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    cl10013
    Location:184261
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
  3. NM_017886.4NP_060356.2  serine/threonine-protein kinase ULK4 isoform 1

    See identical proteins and their annotated locations for NP_060356.2

    Status: REVIEWED

    Source sequence(s)
    AC104305, AC137935, AK304341, BC018795, HY051714
    Consensus CDS
    CCDS43071.1
    UniProtKB/Swiss-Prot
    Q96C45
    Related
    ENSP00000301831.4, ENST00000301831.9
    Conserved Domains (4) summary
    smart00220
    Location:4279
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00020
    Location:646756
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    cd14010
    Location:3280
    STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
    cl10013
    Location:486563
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

RNA

  1. NR_136342.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC097356, AC099059, AC099537, AC104305, AC104307, AC137935, BC018795

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    41246599..41962103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533880.3XP_011532182.1  serine/threonine-protein kinase ULK4 isoform X1

    Conserved Domains (1) summary
    cd00020
    Location:37147
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
  2. XM_024453612.1XP_024309380.1  serine/threonine-protein kinase ULK4 isoform X2

  3. XM_024453613.1XP_024309381.1  serine/threonine-protein kinase ULK4 isoform X3

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