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HCFC1R1 host cell factor C1 regulator 1 [ Homo sapiens (human) ]

Gene ID: 54985, updated on 1-Jun-2020

Summary

Official Symbol
HCFC1R1provided by HGNC
Official Full Name
host cell factor C1 regulator 1provided by HGNC
Primary source
HGNC:HGNC:21198
See related
Ensembl:ENSG00000103145 MIM:618818
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPIP
Expression
Ubiquitous expression in kidney (RPKM 18.6), prostate (RPKM 18.2) and 25 other tissues See more
Orthologs

Genomic context

See HCFC1R1 in Genome Data Viewer
Location:
16p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (3022620..3024286, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3072626..3074287, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene claudin 6 Neighboring gene TNF receptor superfamily member 12A Neighboring gene THO complex 6 Neighboring gene BICD family like cargo adaptor 2 Neighboring gene uncharacterized LOC100128770 Neighboring gene matrix metallopeptidase 25 Neighboring gene MMP25 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20568, MGC70711, MGC99622

Gene Ontology Provided by GOA

Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
host cell factor C1 regulator 1
Names
HCF-1 beta-propeller-interacting protein
host cell factor C1 regulator 1 (XPO1 dependent)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002017.2NP_001002017.1  host cell factor C1 regulator 1 isoform 2

    See identical proteins and their annotated locations for NP_001002017.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Both variants 2 and 5 encode the same isoform.
    Source sequence(s)
    BC064026, BM790570, BU633901
    Consensus CDS
    CCDS32375.1
    UniProtKB/Swiss-Prot
    Q9NWW0
    Related
    ENSP00000459178.1, ENST00000574151.5
    Conserved Domains (1) summary
    pfam15226
    Location:2113
    HPIP; HCF-1 beta-propeller-interacting protein family
  2. NM_001002018.2NP_001002018.1  host cell factor C1 regulator 1 isoform 1

    See identical proteins and their annotated locations for NP_001002018.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 3, and 4 encode the same isoform (1).
    Source sequence(s)
    BC064026, BM790570, BU633901
    Consensus CDS
    CCDS10490.1
    UniProtKB/Swiss-Prot
    Q9NWW0
    Related
    ENSP00000458628.1, ENST00000573842.1
    Conserved Domains (1) summary
    pfam15226
    Location:2132
    HPIP; HCF-1 beta-propeller-interacting protein family
  3. NM_001288665.1NP_001275594.1  host cell factor C1 regulator 1 isoform 1

    See identical proteins and their annotated locations for NP_001275594.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 3, and 4 encode the same isoform (1).
    Source sequence(s)
    BC064026, BM790570, BU633901
    Consensus CDS
    CCDS10490.1
    UniProtKB/Swiss-Prot
    Q9NWW0
    Related
    ENSP00000460639.1, ENST00000574980.5
    Conserved Domains (1) summary
    pfam15226
    Location:2132
    HPIP; HCF-1 beta-propeller-interacting protein family
  4. NM_001288666.1NP_001275595.1  host cell factor C1 regulator 1 isoform 2

    See identical proteins and their annotated locations for NP_001275595.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Both variants 2 and 5 encode the same isoform.
    Source sequence(s)
    BC064026, BM790570, BU633901
    Consensus CDS
    CCDS32375.1
    UniProtKB/Swiss-Prot
    Q9NWW0
    Conserved Domains (1) summary
    pfam15226
    Location:2113
    HPIP; HCF-1 beta-propeller-interacting protein family
  5. NM_001288667.1NP_001275596.1  host cell factor C1 regulator 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an exon and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (3) has a distinct and shorter internal segment, compared to isoform 1.
    Source sequence(s)
    BC064026, BM790570, BU633901, CN427571
    Consensus CDS
    CCDS73815.1
    UniProtKB/Swiss-Prot
    Q9NWW0
    UniProtKB/TrEMBL
    J3KNY1
    Related
    ENSP00000346708.3, ENST00000354679.3
    Conserved Domains (1) summary
    pfam15226
    Location:2130
    HPIP; HCF-1 beta-propeller-interacting protein family
  6. NM_001288668.1NP_001275597.1  host cell factor C1 regulator 1 isoform 4

    See identical proteins and their annotated locations for NP_001275597.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC064026, BM790570, BU633901, CN427571
    UniProtKB/Swiss-Prot
    Q9NWW0
    Related
    ENST00000573095.1
    Conserved Domains (1) summary
    pfam15226
    Location:171
    HPIP; HCF-1 beta-propeller-interacting protein family
  7. NM_001308070.1NP_001294999.1  host cell factor C1 regulator 1 isoform 5

    See identical proteins and their annotated locations for NP_001294999.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site in the 5' UTR which results in the use of a downstream start codon compared to variant 1. The encoded isoform (5) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC108134, BU623445, BU633901
    Consensus CDS
    CCDS76810.1
    UniProtKB/TrEMBL
    I3L1N5
    Related
    ENSP00000458971.1, ENST00000572355.5
    Conserved Domains (1) summary
    pfam15226
    Location:192
    HPIP; HCF-1 beta-propeller-interacting protein family
  8. NM_017885.4NP_060355.1  host cell factor C1 regulator 1 isoform 1

    See identical proteins and their annotated locations for NP_060355.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 3, and 4 encode the same isoform.
    Source sequence(s)
    AC108134
    Consensus CDS
    CCDS10490.1
    UniProtKB/Swiss-Prot
    Q9NWW0
    Related
    ENSP00000248089.3, ENST00000248089.7
    Conserved Domains (1) summary
    pfam15226
    Location:2132
    HPIP; HCF-1 beta-propeller-interacting protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    3022620..3024286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023384.1XP_016878873.1  host cell factor C1 regulator 1 isoform X1

    UniProtKB/TrEMBL
    J3KNY1
    Conserved Domains (1) summary
    pfam15226
    Location:2130
    HPIP; HCF-1 beta-propeller-interacting protein family
  2. XM_011522559.3XP_011520861.1  host cell factor C1 regulator 1 isoform X2

    See identical proteins and their annotated locations for XP_011520861.1

    Conserved Domains (1) summary
    pfam15226
    Location:171
    HPIP; HCF-1 beta-propeller-interacting protein family
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