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NMRK1 nicotinamide riboside kinase 1 [ Homo sapiens (human) ]

Gene ID: 54981, updated on 7-Jun-2020

Summary

Official Symbol
NMRK1provided by HGNC
Official Full Name
nicotinamide riboside kinase 1provided by HGNC
Primary source
HGNC:HGNC:26057
See related
Ensembl:ENSG00000106733 MIM:608704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRK1; C9orf95; bA235O14.2
Summary
Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the vitamin precursors of NAD+. Nicotinamide riboside kinases, such as NRK1, function to synthesize NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner, 2004 [PubMed 15137942]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in thyroid (RPKM 7.5), skin (RPKM 6.5) and 25 other tissues See more
Orthologs

Genomic context

See NMRK1 in Genome Data Viewer
Location:
9q21.13
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (75060577..75088319, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (77676116..77703133, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene CARNMT1 antisense RNA 1 Neighboring gene chromosome 9 open reading frame 40 Neighboring gene carnosine N-methyltransferase 1 Neighboring gene osteoclast stimulating factor 1 Neighboring gene uncharacterized LOC105376090

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20559

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosylnicotinamide kinase activity EXP
Inferred from Experiment
more info
PubMed 
ribosylnicotinate kinase activity EXP
Inferred from Experiment
more info
PubMed 
Process Evidence Code Pubs
NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
NAD metabolic process TAS
Traceable Author Statement
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
nicotinamide riboside kinase 1
Names
NRK 1
RNK 1
nicotinic acid riboside kinase 1
nmR-K 1
ribosylnicotinamide kinase 1
ribosylnicotinic acid kinase 1
NP_001121075.1
NP_001317607.1
NP_001317608.1
NP_060351.1
XP_006717226.1
XP_011517119.1
XP_016870357.1
XP_016870358.1
XP_016870359.1
XP_016870360.1
XP_016870361.1
XP_016870362.1
XP_016870363.1
XP_024303358.1
XP_024303359.1
XP_024303360.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127603.2NP_001121075.1  nicotinamide riboside kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_001121075.1

    Status: VALIDATED

    Source sequence(s)
    AL133548, BC036804
    Consensus CDS
    CCDS47981.1
    UniProtKB/Swiss-Prot
    Q9NWW6
    Related
    ENSP00000366004.4, ENST00000376808.8
    Conserved Domains (1) summary
    cd02024
    Location:5136
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
  2. NM_001330678.2NP_001317607.1  nicotinamide riboside kinase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AA412267, AK097144, AL133548, BC036804, CA440629
    Consensus CDS
    CCDS83374.1
    UniProtKB/Swiss-Prot
    Q9NWW6
    UniProtKB/TrEMBL
    B3KUG3, Q5W125
    Related
    ENSP00000366007.1, ENST00000376811.5
    Conserved Domains (1) summary
    cd02024
    Location:12164
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
  3. NM_001330679.2NP_001317608.1  nicotinamide riboside kinase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AA412267, AK097144, AL133548, AL555401, BE502779, CA440629
    Consensus CDS
    CCDS83374.1
    UniProtKB/TrEMBL
    B3KUG3, Q5W125
    Conserved Domains (1) summary
    cd02024
    Location:12164
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
  4. NM_017881.3NP_060351.1  nicotinamide riboside kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_060351.1

    Status: VALIDATED

    Source sequence(s)
    AK000566, AL133548, BC036804
    Consensus CDS
    CCDS6650.1
    UniProtKB/Swiss-Prot
    Q9NWW6
    Related
    ENSP00000354387.4, ENST00000361092.9
    Conserved Domains (1) summary
    cd02024
    Location:5160
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    75060577..75088319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014874.1XP_016870363.1  nicotinamide riboside kinase 1 isoform X4

    UniProtKB/Swiss-Prot
    Q9NWW6
    Conserved Domains (1) summary
    cd02024
    Location:5136
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
  2. XM_006717163.2XP_006717226.1  nicotinamide riboside kinase 1 isoform X2

    See identical proteins and their annotated locations for XP_006717226.1

    UniProtKB/Swiss-Prot
    Q9NWW6
    Conserved Domains (1) summary
    cd02024
    Location:5160
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
  3. XM_017014873.1XP_016870362.1  nicotinamide riboside kinase 1 isoform X3

    Conserved Domains (1) summary
    cd02024
    Location:12140
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
  4. XM_017014872.1XP_016870361.1  nicotinamide riboside kinase 1 isoform X3

    Conserved Domains (1) summary
    cd02024
    Location:12140
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
  5. XM_017014868.1XP_016870357.1  nicotinamide riboside kinase 1 isoform X1

    UniProtKB/TrEMBL
    Q5W125
    Conserved Domains (1) summary
    cd02024
    Location:12164
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
  6. XM_017014870.2XP_016870359.1  nicotinamide riboside kinase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9NWW6
    Conserved Domains (1) summary
    cd02024
    Location:5160
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
  7. XM_017014869.2XP_016870358.1  nicotinamide riboside kinase 1 isoform X1

    UniProtKB/TrEMBL
    Q5W125
    Conserved Domains (1) summary
    cd02024
    Location:12164
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
  8. XM_024447590.1XP_024303358.1  nicotinamide riboside kinase 1 isoform X1

    Conserved Domains (1) summary
    cd02024
    Location:12164
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
  9. XM_024447591.1XP_024303359.1  nicotinamide riboside kinase 1 isoform X3

    Conserved Domains (1) summary
    cd02024
    Location:12140
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
  10. XM_017014871.1XP_016870360.1  nicotinamide riboside kinase 1 isoform X3

    Conserved Domains (1) summary
    cd02024
    Location:12140
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
  11. XM_024447592.1XP_024303360.1  nicotinamide riboside kinase 1 isoform X3

    Conserved Domains (1) summary
    cd02024
    Location:12140
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
  12. XM_011518817.1XP_011517119.1  nicotinamide riboside kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_011517119.1

    UniProtKB/TrEMBL
    Q5W125
    Conserved Domains (1) summary
    cd02024
    Location:12164
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

RNA

  1. XR_002956795.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_023352.1: Suppressed sequence

    Description
    NR_023352.1: This RefSeq was removed because it is now thought that this transcript encodes a protein.
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