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PLAAT2 phospholipase A and acyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 54979, updated on 25-Nov-2021

Summary

Official Symbol
PLAAT2provided by HGNC
Official Full Name
phospholipase A and acyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:17824
See related
Ensembl:ENSG00000133328 MIM:613866
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRASLS2; PLAAT-2; PLA1/2-2
Summary
The protein encoded by this gene has both phospholipase and acyltransferase activities and acts as a tumor suppressor. The encoded protein can hydrolyze dipalmitoylated phosphatidylcholine (PC) to palmitic acid and lyso-PC. In addition, this protein can catalyze the N-acylation of phosphatidylethanolamine and can catalyze the O-acylation of lyso-PC to form PC. [provided by RefSeq, Jul 2016]
Expression
Biased expression in duodenum (RPKM 16.4), small intestine (RPKM 9.9) and 3 other tissues See more
Orthologs
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Genomic context

See PLAAT2 in Genome Data Viewer
Location:
11q12.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (63552759..63565072, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63320242..63330851, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8142 Neighboring gene phospholipase A and acyltransferase 4 Neighboring gene CRISPRi-validated cis-regulatory element chr11.2897 Neighboring gene uncharacterized LOC105369335 Neighboring gene phospholipase A and acyltransferase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ20556

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-acyl-2-lysophosphatidylserine acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables N-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acyltransferase activity TAS
Traceable Author Statement
more info
 
enables phosphatidylserine 1-acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A1 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase A1 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phospholipase A and acyltransferase 2
Names
HRAS like suppressor 2
phospholipase A/acyltransferase-2
NP_060348.1
XP_011543422.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017878.2NP_060348.1  phospholipase A and acyltransferase 2

    See identical proteins and their annotated locations for NP_060348.1

    Status: REVIEWED

    Source sequence(s)
    AK000563
    Consensus CDS
    CCDS8046.1
    UniProtKB/Swiss-Prot
    Q9NWW9
    Related
    ENSP00000255695.1, ENST00000255695.2
    Conserved Domains (1) summary
    pfam04970
    Location:20125
    LRAT; Lecithin retinol acyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    63552759..63565072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545120.2XP_011543422.1  phospholipase A and acyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_011543422.1

    Conserved Domains (1) summary
    pfam04970
    Location:53158
    LRAT; Lecithin retinol acyltransferase
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