Format

Send to:

Choose Destination

C20orf27 chromosome 20 open reading frame 27 [ Homo sapiens (human) ]

Gene ID: 54976, updated on 20-Dec-2019

Summary

Official Symbol
C20orf27provided by HGNC
Official Full Name
chromosome 20 open reading frame 27provided by HGNC
Primary source
HGNC:HGNC:15873
See related
Ensembl:ENSG00000101220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in bone marrow (RPKM 20.0), fat (RPKM 18.1) and 24 other tissues See more
Orthologs

Genomic context

See C20orf27 in Genome Data Viewer
Location:
20p13
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (3753499..3768388, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3734146..3749035, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene sialic acid binding Ig like lectin 1 Neighboring gene Sharpr-MPRA regulatory region 3812 Neighboring gene heat shock protein family A (Hsp70) member 12B Neighboring gene Sharpr-MPRA regulatory region 2213 Neighboring gene sperm flagellar 1 Neighboring gene centromere protein B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20550

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039140.3NP_001034229.1  UPF0687 protein C20orf27 isoform 1

    See identical proteins and their annotated locations for NP_001034229.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK024220, BF978883, BG474804, DB317576
    Consensus CDS
    CCDS33436.1
    UniProtKB/Swiss-Prot
    Q9GZN8
    Related
    ENSP00000217195.8, ENST00000217195.12
    Conserved Domains (1) summary
    pfam15006
    Location:53198
    DUF4517; Domain of unknown function (DUF4517)
  2. NM_001258429.2NP_001245358.1  UPF0687 protein C20orf27 isoform 2

    See identical proteins and their annotated locations for NP_001245358.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    AK024220, BF978883, DB317576
    Consensus CDS
    CCDS58763.1
    UniProtKB/Swiss-Prot
    Q9GZN8
    Related
    ENSP00000369097.3, ENST00000379772.3
    Conserved Domains (1) summary
    pfam15006
    Location:28173
    DUF4517; Domain of unknown function (DUF4517)
  3. NM_001258430.2NP_001245359.1  UPF0687 protein C20orf27 isoform 2

    See identical proteins and their annotated locations for NP_001245359.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. Variants 2 and 3 encoded the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    AK024220, BC069204, DB317576
    Consensus CDS
    CCDS58763.1
    UniProtKB/Swiss-Prot
    Q9GZN8
    Related
    ENSP00000382580.1, ENST00000399672.5
    Conserved Domains (1) summary
    pfam15006
    Location:28173
    DUF4517; Domain of unknown function (DUF4517)

RNA

  1. NR_047675.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5'-most exon and an alternate splice site, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK290955, AL109804, DB317576

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    3753499..3768388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529266.3XP_011527568.1  UPF0687 protein C20orf27 isoform X1

    Related
    ENSP00000382591.3, ENST00000399683.7
    Conserved Domains (1) summary
    pfam15006
    Location:53157
    DUF4517; Domain of unknown function (DUF4517)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_017874.2: Suppressed sequence

    Description
    NM_017874.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center