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TMEM132A transmembrane protein 132A [ Homo sapiens (human) ]

Gene ID: 54972, updated on 8-Jul-2021

Summary

Official Symbol
TMEM132Aprovided by HGNC
Official Full Name
transmembrane protein 132Aprovided by HGNC
Primary source
HGNC:HGNC:31092
See related
Ensembl:ENSG00000006118 MIM:617363
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GBP; HSPA5BP1
Summary
This gene encodes a protein that is highly similar to the rat Grp78-binding protein (GBP). Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 20.0), endometrium (RPKM 7.5) and 12 other tissues See more
Orthologs
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Genomic context

See TMEM132A in Genome Data Viewer
Location:
11q12.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (60924460..60937159)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60691932..60704631)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene TMEM109 divergent transcript Neighboring gene transmembrane protein 109 Neighboring gene solute carrier family 15 member 3 Neighboring gene CD6 molecule Neighboring gene RNA, U6 small nuclear 933, pseudogene Neighboring gene tRNA-Ala (TGC) 10-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of transmembrane protein 132A (TMEM132A; HSPA5BP1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20539, MGC138669, DKFZp547E212

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 132A
Names
GRP78-binding protein
HSPA5-binding protein 1
glucose-regulated protein, 78kDa
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) binding protein 1
heat shock 70kDa protein 5 binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017870.4NP_060340.2  transmembrane protein 132A isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK000546, AK023577, AL359557, AP003721, BC028106, BC032059
    Consensus CDS
    CCDS7997.1
    UniProtKB/Swiss-Prot
    Q24JP5
    Related
    ENSP00000005286.4, ENST00000005286.8
    Conserved Domains (3) summary
    pfam15705
    Location:50171
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:837904
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:408750
    TMEM132; Transmembrane protein family 132
  2. NM_178031.3NP_821174.1  transmembrane protein 132A isoform b precursor

    See identical proteins and their annotated locations for NP_821174.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different in-frame splice site in the coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
    Source sequence(s)
    AK000546, AL359557, AP003721, BC028106
    Consensus CDS
    CCDS44618.1
    UniProtKB/Swiss-Prot
    Q24JP5
    Related
    ENSP00000405823.2, ENST00000453848.7
    Conserved Domains (3) summary
    pfam15705
    Location:48170
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:836901
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:407749
    TMEM132; Transmembrane protein family 132

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    60924460..60937159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017951.2XP_016873440.1  transmembrane protein 132A isoform X1

  2. XM_017017952.2XP_016873441.1  transmembrane protein 132A isoform X2

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